Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1558508..1559130 Replicon chromosome
Accession NZ_CP029449
Organism Serratia marcescens strain CAV1761

Toxin (Protein)


Gene name Hha Uniprot ID A0A8B4G7F9
Locus tag DKC05_RS09535 Protein ID WP_004940313.1
Coordinates 1558927..1559130 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A2X2G5J9
Locus tag DKC05_RS09530 Protein ID WP_004940312.1
Coordinates 1558508..1558876 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DKC05_RS09500 1554601..1554855 + 255 WP_038874985.1 type B 50S ribosomal protein L31 -
DKC05_RS09505 1554868..1555008 + 141 WP_004940304.1 type B 50S ribosomal protein L36 -
DKC05_RS09510 1555115..1555993 - 879 WP_038874983.1 zinc ABC transporter substrate-binding protein -
DKC05_RS09515 1556019..1556876 - 858 WP_047728662.1 metal ABC transporter permease -
DKC05_RS09520 1556873..1557586 - 714 WP_047728664.1 ABC transporter ATP-binding protein -
DKC05_RS09525 1557996..1558349 + 354 WP_038874974.1 hypothetical protein -
DKC05_RS09530 1558508..1558876 + 369 WP_004940312.1 Hha toxicity modulator TomB Antitoxin
DKC05_RS09535 1558927..1559130 + 204 WP_004940313.1 hemolysin expression modulator Hha Toxin
DKC05_RS09540 1559414..1559932 - 519 WP_047728667.1 cytochrome b/b6 domain-containing protein -
DKC05_RS09545 1559985..1561412 - 1428 WP_047728669.1 N-acetylglucosamine-binding protein GbpA -
DKC05_RS09550 1561665..1562027 + 363 WP_047728672.1 type II secretion system pilot lipoprotein GspS -
DKC05_RS09555 1562024..1562839 - 816 WP_047728674.1 A24 family peptidase -
DKC05_RS09560 1562876..1563322 - 447 WP_047728676.1 type II secretion system protein M -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8107.37 Da        Isoelectric Point: 6.9756

>T105664 WP_004940313.1 NZ_CP029449:1558927-1559130 [Serratia marcescens]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPTSVWKYVR

Download         Length: 204 bp

>T105664 NZ_CP029449:1558927-1559130 [Serratia marcescens]
ATGACTAAAACCGACTATCTGATGCGTTTACGTAAATGCACCACGATTGATACTCTCGAACGTGTTATTGAGAAAAATAA
GTACGAGCTTTCCGATGATGAACTGGAGCTGTTTTACTCAGCGGCCGATCACCGTCTGGCGGAGCTCACCATGAACAAAC
TGTATGACAAAATCCCCACCTCCGTTTGGAAATATGTCAGGTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14261.95 Da        Isoelectric Point: 4.4314

>AT105664 WP_004940312.1 NZ_CP029449:1558508-1558876 [Serratia marcescens]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSSVNLQLNELIEHIASFVMSYKIKYMDESDLSELVEEYL
DDTYTLFSSYGINDSDLRRWQKTKARLFRMFSGEDICTTMKT

Download         Length: 369 bp

>AT105664 NZ_CP029449:1558508-1558876 [Serratia marcescens]
ATGGATGAGTATTCGCCTAAGCGACACGACATTGCTCAGCTCAAATTCTTGTGCGAAAATTTGTATGATGAAGGTATCGC
GACCTTGGGAGACAGCCACCACGGGTGGGTCAACGATCCGACATCCTCCGTCAACCTGCAGCTTAATGAGTTGATCGAAC
ATATCGCTTCGTTTGTGATGAGTTATAAAATTAAATACATGGACGAATCAGACCTGTCGGAGTTAGTCGAAGAATATCTC
GACGATACTTATACGCTGTTCAGCAGCTACGGTATCAATGATTCCGACCTGCGCCGCTGGCAAAAGACCAAGGCGAGATT
ATTCAGAATGTTCTCAGGAGAGGACATCTGTACGACAATGAAAACTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4G7F9

Antitoxin

Source ID Structure
AlphaFold DB A0A2X2G5J9

References