Detailed information of TA system TA105662

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 858518..859113
• Replicon: chromosome
• Accession: NZ_CP029449
• Organism: Serratia marcescens strain CAV1761

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A1S6LRI1
• Locus tag: DKC05_RS06135
• Protein ID: WP_071605322.1
• Coordinates: 858859..859113 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: DKC05_RS06130
• Protein ID: WP_033633573.1
• Coordinates: 858518..858859 (-)
• Length: 114 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DKC05_RS06110	854859..855074	-	216	WP_071845399.1	ogr/Delta-like zinc finger family protein	-
DKC05_RS06115	855025..856133	+	1109	Protein_819	oxidoreductase	-
DKC05_RS06120	856133..857155	+	1023	WP_047728002.1	phage portal protein	-
DKC05_RS06125	857193..858398	-	1206	WP_071845277.1	ISL3 family transposase	-
DKC05_RS06130	858518..858859	-	342	WP_033633573.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
DKC05_RS06135	858859..859113	-	255	WP_071605322.1	type II toxin-antitoxin system HicA family toxin	Toxin
DKC05_RS06140	859767..860468	-	702	WP_038881175.1	hypothetical protein	-
DKC05_RS06145	860625..860885	+	261	WP_139145145.1	hypothetical protein	-
DKC05_RS06150	860918..861142	-	225	WP_047728004.1	hypothetical protein	-
DKC05_RS06155	861181..862156	-	976	Protein_827	replication endonuclease	-
DKC05_RS06160	862324..863067	-	744	WP_047728005.1	ankyrin repeat domain-containing protein	-
DKC05_RS06165	863157..863930	-	774	WP_038881165.1	ankyrin repeat domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	855031..866996	11965

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (23-81)

Antitoxin

• Uncharacterised protein family HicB (55-100)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9495.97 Da
• Isoelectric Point: 11.1073

>T105662 WP_071605322.1 NZ_CP029449:c859113-858859 [Serratia marcescens]
MNKRHQKTLSDVFARPVNGSIKWSDIEALFTALGAEIHEREGSRIAVLLKGEKRVFHRPHPRPTTDKGAVNSIRIWLDSL
GIKP

Nucleotide

• Length: 255 bp

>T105662 NZ_CP029449:c859113-858859 [Serratia marcescens]
ATGAACAAACGACACCAAAAAACGCTGTCAGATGTGTTTGCCCGGCCTGTCAACGGTTCTATAAAGTGGTCTGATATTGA
GGCGCTTTTTACCGCATTAGGGGCGGAGATTCACGAAAGGGAAGGTTCTAGGATCGCGGTGCTGTTGAAAGGTGAAAAAA
GAGTCTTTCACCGGCCACACCCCAGACCTACCACTGACAAGGGGGCGGTTAACTCTATTCGGATCTGGTTGGATAGCTTA
GGAATAAAACCATGA

Antitoxin

Protein

• Length: 114 a.a.
• Molecular weight: 12399.90 Da
• Isoelectric Point: 4.5789

>AT105662 WP_033633573.1 NZ_CP029449:c858859-858518 [Serratia marcescens]
MNNTLKIDGHTAVINFDPEIEMFRGEFVGLNGGADFYAYSVDELKKEGAISLAVFLDECHKDGIEPYKSYSGKVTTRLSP
ERHQALAIAAQATGQSINELLNEGVDLVIEKHS

Nucleotide

• Length: 342 bp

>AT105662 NZ_CP029449:c858859-858518 [Serratia marcescens]
ATGAATAACACACTGAAAATTGACGGCCATACGGCCGTCATCAACTTCGACCCAGAAATTGAAATGTTCCGGGGCGAGTT
TGTCGGGCTGAACGGTGGCGCCGACTTCTACGCCTACAGCGTGGACGAGCTGAAGAAAGAAGGCGCGATCTCACTCGCGG
TCTTTCTCGATGAGTGCCATAAAGACGGCATCGAGCCTTACAAGTCGTACAGCGGCAAAGTAACCACCCGCCTGTCGCCG
GAACGCCATCAGGCGTTAGCCATTGCCGCTCAGGCCACCGGGCAGTCGATTAATGAACTGCTGAATGAAGGTGTTGATCT
GGTTATCGAAAAGCATTCCTGA

Structures

Toxin

• AlphaFold DB: A0A1S6LRI1