Detailed information of TA system TA105652

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicB-HicA
• Location: 5724980..5725572
• Replicon: chromosome
• Accession: NZ_CP029427
• Organism: Bradyrhizobium symbiodeficiens strain 85S1MB

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: CIT39_RS27180
• Protein ID: WP_094976673.1
• Coordinates: 5724980..5725168 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: CIT39_RS27185
• Protein ID: WP_094976672.1
• Coordinates: 5725174..5725572 (+)
• Length: 133 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CIT39_RS27160	5721410..5722426	+	1017	WP_094976677.1	TRAP transporter substrate-binding protein	-
CIT39_RS27165	5722630..5723139	+	510	WP_094976676.1	TRAP transporter small permease	-
CIT39_RS27170	5723142..5724461	+	1320	WP_094976675.1	TRAP transporter permease	-
CIT39_RS27175	5724474..5724935	+	462	WP_094976674.1	DUF3237 domain-containing protein	-
CIT39_RS27180	5724980..5725168	+	189	WP_094976673.1	type II toxin-antitoxin system HicA family toxin	Toxin
CIT39_RS27185	5725174..5725572	+	399	WP_094976672.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
CIT39_RS27190	5725701..5726510	+	810	WP_094976671.1	crotonase/enoyl-CoA hydratase family protein	-
CIT39_RS27195	5726507..5728390	+	1884	WP_094976670.1	feruloyl-CoA synthase	-
CIT39_RS27200	5728418..5729179	+	762	WP_094976669.1	SDR family NAD(P)-dependent oxidoreductase	-
CIT39_RS27205	5729192..5729611	+	420	WP_094976668.1	acyl-CoA thioesterase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-124)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7009.08 Da
• Isoelectric Point: 11.9537

>T105652 WP_094976673.1 NZ_CP029427:5724980-5725168 [Bradyrhizobium symbiodeficiens]
MNSRDIISALHRDGWVQVAQKGSHVQFRHPTKKGRVTVPHPKRDIALGTLKSIEQQSGLQLR

Nucleotide

• Length: 189 bp

>T105652 NZ_CP029427:5724980-5725168 [Bradyrhizobium symbiodeficiens]
ATGAATAGCCGAGACATCATCTCGGCCCTTCACAGGGATGGCTGGGTGCAAGTGGCTCAGAAGGGCAGCCACGTCCAGTT
CAGGCATCCGACCAAAAAGGGCCGCGTGACGGTCCCTCATCCGAAGCGAGACATCGCGCTCGGAACGTTGAAGAGCATTG
AACAGCAATCAGGACTGCAACTGAGGTAA

Antitoxin

Protein

• Length: 133 a.a.
• Molecular weight: 14103.83 Da
• Isoelectric Point: 4.2376

>AT105652 WP_094976672.1 NZ_CP029427:5725174-5725572 [Bradyrhizobium symbiodeficiens]
MRHYIGLIHKDADSDFGVSFPDLPGVVTAGSTLDEARDMAEEALAFHLEGLEEDGEAIPEPSSLEDIMSDPANRSGVAIL
VSVKDGQPKIVRVNVTLPGDVLEQIDKYAEAHGYTRSGLLAQAAKKLMTEAA

Nucleotide

• Length: 399 bp

>AT105652 NZ_CP029427:5725174-5725572 [Bradyrhizobium symbiodeficiens]
ATGCGTCACTATATTGGTCTTATCCATAAGGATGCCGACAGCGATTTCGGCGTGTCGTTTCCTGACCTGCCCGGCGTTGT
GACTGCGGGGTCCACCCTGGATGAAGCGCGGGACATGGCCGAAGAAGCGCTGGCGTTTCATCTTGAAGGGCTGGAAGAAG
ACGGCGAGGCTATTCCCGAGCCTTCGTCGCTCGAAGACATCATGTCGGATCCCGCGAACCGCTCTGGCGTCGCCATTCTG
GTGTCGGTGAAAGATGGCCAGCCCAAGATCGTACGCGTCAATGTCACGTTGCCCGGTGACGTCCTGGAGCAGATCGACAA
GTACGCTGAAGCCCACGGCTACACACGATCGGGCCTGCTTGCCCAGGCCGCAAAAAAGCTGATGACTGAAGCCGCCTGA