Detailed information of TA system TA105627

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 3776444..3777264
• Replicon: chromosome
• Accession: NZ_CP029420
• Organism: Escherichia coli strain 3385

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: B6I030
• Locus tag: DFS94_RS18755
• Protein ID: WP_001054379.1
• Coordinates: 3776444..3776701 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: DFS94_RS18760
• Protein ID: WP_000123957.1
• Coordinates: 3776713..3777264 (+)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DFS94_RS18740	3774306..3774560	-	255	WP_000788354.1	glycosyltransferase	-
DFS94_RS18745	3774723..3775870	+	1148	WP_085949154.1	IS3-like element ISEc52 family transposase	-
DFS94_RS18750	3775903..3776067	+	165	Protein_3592	GNAT family N-acetyltransferase	-
DFS94_RS18755	3776444..3776701	+	258	WP_001054379.1	YjhX family toxin	Toxin
DFS94_RS18760	3776713..3777264	+	552	WP_000123957.1	N-acetyltransferase	Antitoxin
DFS94_RS18765	3777316..3778062	+	747	WP_000354249.1	class I SAM-dependent methyltransferase	-
DFS94_RS18770	3778190..3778450	+	261	WP_000077645.1	hypothetical protein	-
DFS94_RS25805	3778488..3778604	+	117	Protein_3597	VOC family protein	-
DFS94_RS18775	3778849..3779970	+	1122	WP_000010833.1	M42 family metallopeptidase	-
DFS94_RS18780	3779967..3780245	+	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
DFS94_RS18785	3780257..3781570	+	1314	WP_000460845.1	galactitol-specific PTS transporter subunit IIC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3748391..3785485	37094

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (19-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9568.07 Da
• Isoelectric Point: 11.1381

>T105627 WP_001054379.1 NZ_CP029420:3776444-3776701 [Escherichia coli]
MNLSRQEQRTLHVLAKGGRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T105627 NZ_CP029420:3776444-3776701 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACGTACGTTACACGTTCTCGCTAAAGGTGGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGTCAGCCCTATCGAATCAACACTACCGGGCTGAATAACGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20358.34 Da
• Isoelectric Point: 6.4182

>AT105627 WP_000123957.1 NZ_CP029420:3776713-3777264 [Escherichia coli]
MTAHHFTFQITDESDASDIREVETRAFGFSKEADLTASLLEDESARPALSLLARHEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQALTA
QPMNVTGHIQCAQALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT105627 NZ_CP029420:3776713-3777264 [Escherichia coli]
ATGACAGCACACCACTTCACTTTTCAAATCACAGATGAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAACGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCTGCGTTATCGCTGCTGGCCC
GACATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGGGAAATGGATTCACCGCTGATGCAT
ATCCTCGCTCCCCTGGCAGTCATACCGGAATACCAGGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAAGCACTCACCGCT
CAGCCCATGAACGTGACCGGCCACATCCAGTGCGCGCAGGCCCTGATGAAACCGGAGCACTGGCGTGAATAA

Structures

Toxin

• AlphaFold DB: B6I030