Detailed information of TA system TA105602

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 1879785..1880400
• Replicon: chromosome
• Accession: NZ_CP029398
• Organism: Streptococcus suis strain HN105

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: DF184_RS09260
• Protein ID: WP_161496224.1
• Coordinates: 1879785..1880120 (-)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A075SJ65
• Locus tag: DF184_RS09265
• Protein ID: WP_024381089.1
• Coordinates: 1880113..1880400 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DF184_RS09240	1875855..1876628	-	774	WP_109371946.1	nucleoside phosphorylase	-
DF184_RS09245	1876643..1877260	-	618	WP_109371947.1	serine O-acetyltransferase	-
DF184_RS09250	1877314..1879533	-	2220	WP_109371949.1	polyribonucleotide nucleotidyltransferase	-
DF184_RS09260	1879785..1880120	-	336	WP_161496224.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DF184_RS09265	1880113..1880400	-	288	WP_024381089.1	XRE family transcriptional regulator	Antitoxin
DF184_RS09270	1880716..1880985	-	270	WP_002938849.1	30S ribosomal protein S15	-
DF184_RS09275	1881189..1882466	-	1278	WP_024393459.1	NCS2 family nucleobase:cation symporter	-
DF184_RS09280	1882662..1884557	-	1896	WP_029751926.1	DUF262 domain-containing HNH endonuclease family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (14-96)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 12783.86 Da
• Isoelectric Point: 9.5189

>T105602 WP_161496224.1 NZ_CP029398:c1880120-1879785 [Streptococcus suis]
MDKYQVNLPLAIYEELAAIRSYIREELKSPDAADKKIQELIAGLRSLEIFPERGFNVDERSKKGPLVPGHLTRGLPIKKD
YIAIYNIDEAQKVVNVRYLVASKSDYMRLFK

Nucleotide

• Length: 336 bp

>T105602 NZ_CP029398:c1880120-1879785 [Streptococcus suis]
TTGGATAAGTACCAAGTAAACCTACCTCTAGCTATATATGAGGAACTAGCTGCCATTCGTAGCTACATCAGGGAAGAACT
AAAAAGTCCTGATGCTGCGGACAAAAAAATCCAAGAGCTAATAGCAGGACTTAGAAGCCTTGAAATTTTCCCAGAGCGAG
GTTTTAACGTAGATGAACGCTCTAAAAAAGGACCGCTAGTCCCAGGTCATCTGACGCGAGGACTACCCATCAAAAAGGAT
TATATAGCTATTTATAACATTGATGAAGCACAAAAGGTCGTAAACGTTCGCTATCTTGTCGCAAGCAAGAGCGACTATAT
GAGATTGTTCAAATAG

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10686.33 Da
• Isoelectric Point: 4.2626

>AT105602 WP_024381089.1 NZ_CP029398:c1880400-1880113 [Streptococcus suis]
MALTAEKKLINFQSEKSLVEEAKEVLASQNMTMTQALNLFLKNIVVTGEIGLKSEEELEKERLFAELQAEVMKNVAEMNA
GNYLSLDEMETKLFG

Nucleotide

• Length: 288 bp

>AT105602 NZ_CP029398:c1880400-1880113 [Streptococcus suis]
ATGGCCTTAACAGCTGAAAAGAAATTGATTAACTTTCAATCAGAAAAATCACTTGTAGAAGAAGCAAAAGAGGTCTTGGC
AAGTCAAAATATGACCATGACACAAGCCCTCAACCTGTTTCTCAAAAATATTGTAGTAACAGGAGAAATTGGACTTAAAA
GTGAAGAAGAACTGGAAAAAGAGCGACTATTTGCCGAACTCCAAGCAGAAGTGATGAAAAATGTAGCTGAAATGAATGCG
GGCAACTATCTATCATTGGACGAAATGGAGACCAAGCTCTTTGGATAA

Structures

Antitoxin

• AlphaFold DB: A0A075SJ65