Detailed information of TA system TA105601

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1510819..1511488
• Replicon: chromosome
• Accession: NZ_CP029398
• Organism: Streptococcus suis strain HN105

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: G7SGM1
• Locus tag: DF184_RS07465
• Protein ID: WP_014637653.1
• Coordinates: 1511306..1511488 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: G7SGM2
• Locus tag: DF184_RS07460
• Protein ID: WP_014637654.1
• Coordinates: 1510819..1511268 (-)
• Length: 150 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DF184_RS07445	1506489..1508408	-	1920	WP_109371729.1	C69 family dipeptidase	-
DF184_RS07450	1508601..1509461	-	861	WP_109371731.1	SAM-dependent methyltransferase TehB	-
DF184_RS07455	1509615..1510658	+	1044	WP_109372152.1	alcohol dehydrogenase catalytic domain-containing protein	-
DF184_RS07460	1510819..1511268	-	450	WP_014637654.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
DF184_RS07465	1511306..1511488	-	183	WP_014637653.1	type II toxin-antitoxin system HicA family toxin	Toxin
DF184_RS07470	1511854..1512084	-	231	WP_162841181.1	hypothetical protein	-
DF184_RS07475	1512351..1512818	-	468	WP_002935771.1	SsrA-binding protein SmpB	-
DF184_RS07480	1512821..1515190	-	2370	WP_109371733.1	ribonuclease R	-
DF184_RS07485	1515563..1515796	-	234	WP_002935768.1	preprotein translocase subunit SecG	-
DF184_RS07490	1515843..1515992	-	150	WP_012775228.1	50S ribosomal protein L33	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (17-114)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6653.87 Da
• Isoelectric Point: 10.8207

>T105601 WP_014637653.1 NZ_CP029398:c1511488-1511306 [Streptococcus suis]
MPMTQKEMVKLLTAHGWTKTKGGKGSHVKLEKAGERPITIPHGEINKYTERGIKKQAGLL

Nucleotide

• Length: 183 bp

>T105601 NZ_CP029398:c1511488-1511306 [Streptococcus suis]
ATGCCTATGACACAAAAAGAAATGGTTAAGCTACTTACCGCCCATGGTTGGACAAAAACCAAAGGCGGTAAGGGGTCACA
CGTGAAACTTGAAAAAGCAGGCGAGCGACCTATAACCATTCCCCACGGTGAAATAAACAAATACACCGAAAGGGGTATCA
AAAAGCAAGCAGGGCTGTTATAA

Antitoxin

Protein

• Length: 150 a.a.
• Molecular weight: 16664.69 Da
• Isoelectric Point: 3.9458

>AT105601 WP_014637654.1 NZ_CP029398:c1511268-1510819 [Streptococcus suis]
MLVTYPALFYFDDTDGANAPYFVTFPDFEYSATQGEDMADAMAMASDWLGMNLADYIENGRDIPTPSSINTLSLVDNNPF
RNEDFEMVYDSSKSFISMVMVDVAKYLGSQEPVKKTLTIPRWADTLGRELGLNFSQTLTDAIADKKIHA

Nucleotide

• Length: 450 bp

>AT105601 NZ_CP029398:c1511268-1510819 [Streptococcus suis]
ATGCTTGTCACTTATCCAGCTTTATTTTATTTTGATGATACAGACGGAGCTAACGCCCCTTACTTTGTAACTTTCCCTGA
TTTTGAGTATTCAGCAACTCAAGGCGAGGATATGGCGGACGCTATGGCAATGGCTAGCGATTGGTTAGGCATGAACTTAG
CTGATTATATCGAGAATGGAAGAGACATTCCTACCCCGTCTTCTATAAACACTTTGTCATTAGTAGATAATAACCCTTTC
CGTAATGAGGATTTTGAGATGGTTTACGATTCTAGCAAGTCTTTTATCTCTATGGTGATGGTGGACGTTGCAAAGTATTT
GGGCAGTCAAGAGCCAGTAAAGAAAACACTCACTATCCCACGCTGGGCAGACACTCTAGGACGTGAACTAGGATTGAATT
TCTCACAGACCCTCACGGATGCAATTGCAGATAAAAAAATTCATGCTTAA

Structures

Toxin

• AlphaFold DB: G7SGM1

Antitoxin

• AlphaFold DB: G7SGM2