Detailed information of TA system TA105600

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1041375..1041876
• Replicon: chromosome
• Accession: NZ_CP029398
• Organism: Streptococcus suis strain HN105

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: DF184_RS05295
• Protein ID: WP_109371427.1
• Coordinates: 1041610..1041876 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A116JQC5
• Locus tag: DF184_RS05290
• Protein ID: WP_029173101.1
• Coordinates: 1041375..1041626 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DF184_RS05265	1036702..1037868	+	1167	WP_024401224.1	ATP-grasp domain-containing protein	-
DF184_RS11015	1038010..1038150	+	141	WP_032532220.1	hypothetical protein	-
DF184_RS05275	1038163..1038552	+	390	WP_024401225.1	NisI/SpaI family lantibiotic immunity lipoprotein	-
DF184_RS05280	1038561..1039313	+	753	WP_024401226.1	ABC transporter ATP-binding protein	-
DF184_RS05285	1039314..1041284	+	1971	WP_109371425.1	FtsX-like permease family protein	-
DF184_RS05290	1041375..1041626	+	252	WP_029173101.1	hypothetical protein	Antitoxin
DF184_RS05295	1041610..1041876	+	267	WP_109371427.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DF184_RS05300	1041915..1042583	+	669	WP_161949707.1	response regulator transcription factor	-
DF184_RS05305	1042580..1043521	+	942	WP_109371428.1	sensor histidine kinase	-
DF184_RS05310	1043598..1045106	+	1509	WP_024401231.1	phosphoglucomutase	-
DF184_RS05315	1045169..1046239	-	1071	WP_105120535.1	tyrosine recombinase XerS	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (10-87)

Antitoxin

• Protein of unknown function DUF6290 (1-75)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10392.08 Da
• Isoelectric Point: 10.6122

>T105600 WP_109371427.1 NZ_CP029398:1041610-1041876 [Streptococcus suis]
MKTCYKLVPTSRFIKQLKKLDKFTQKQITNYLSSHVTENPRQYGKALTANRSGQWRYRIGNYRVIVSIEDDKLIVTALEV
GHRKEVYK

Nucleotide

• Length: 267 bp

>T105600 NZ_CP029398:1041610-1041876 [Streptococcus suis]
ATGAAGACCTGTTATAAACTTGTACCAACCAGTCGTTTTATCAAACAGTTGAAAAAGCTGGACAAATTTACTCAAAAGCA
GATTACCAACTACCTGTCCAGTCATGTGACTGAAAACCCCAGACAATACGGAAAAGCCTTGACTGCTAATCGTTCTGGCC
AATGGCGGTATCGTATCGGAAATTACAGGGTCATCGTCAGTATTGAAGATGATAAATTGATTGTAACTGCCCTTGAAGTC
GGGCATCGAAAAGAAGTATATAAATAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9425.62 Da
• Isoelectric Point: 3.6767

>AT105600 WP_029173101.1 NZ_CP029398:1041375-1041626 [Streptococcus suis]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADIAWAEYQEDLANGIEPISWEEMLEELGLTDE
DLL

Nucleotide

• Length: 252 bp

>AT105600 NZ_CP029398:1041375-1041626 [Streptococcus suis]
ATGGCAGCTATTACATTGAAAGTTTCTGAGCAGGACAAGCTTTTTATGCAGGCTATGGCAAAGTTTGAAGGCGTGAGTTT
GTCAGAACTCATTCGGACTAAAACCCTTGAAGCCCTTGAAGATGAGTATGATGCGCGTGTGGCAGACATTGCTTGGGCAG
AATACCAAGAAGACTTGGCGAATGGAATTGAGCCGATTAGCTGGGAGGAAATGTTGGAAGAGTTGGGGTTGACGGATGAA
GACCTGTTATAA

Structures

Antitoxin

• AlphaFold DB: A0A116JQC5