Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc(toxin)
Location 2642574..2643136 Replicon chromosome
Accession NZ_CP029397
Organism Acinetobacter defluvii strain WCHA30

Toxin (Protein)


Gene name doc Uniprot ID A0A2S2FFS8
Locus tag DJ533_RS15105 Protein ID WP_065994218.1
Coordinates 2642574..2642966 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A2S2FG90
Locus tag DJ533_RS15110 Protein ID WP_065994219.1
Coordinates 2642966..2643136 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DJ533_RS15080 2637883..2638986 - 1104 WP_065994214.1 M48 family metallopeptidase -
DJ533_RS15085 2639008..2640111 - 1104 WP_065994215.1 DUF898 domain-containing protein -
DJ533_RS15095 2640520..2640735 - 216 WP_065994216.1 hypothetical protein -
DJ533_RS15100 2640771..2642336 - 1566 WP_065994217.1 DUF4365 domain-containing protein -
DJ533_RS15105 2642574..2642966 - 393 WP_065994218.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
DJ533_RS15110 2642966..2643136 - 171 WP_065994219.1 acetyltransferase Antitoxin
DJ533_RS15115 2643203..2645821 - 2619 WP_065994220.1 Fe/S-dependent 2-methylisocitrate dehydratase AcnD -
DJ533_RS15120 2646058..2646780 + 723 WP_065994221.1 aminomethyltransferase -
DJ533_RS15125 2646860..2647852 + 993 WP_065994222.1 hypothetical protein -
DJ533_RS15130 2647890..2648119 - 230 Protein_2452 glucose/sorbosone dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(1-127)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14395.35 Da        Isoelectric Point: 4.1490

>T105597 WP_065994218.1 NZ_CP029397:c2642966-2642574 [Acinetobacter defluvii]
MEIICFPFERVIEINAFILSTEKGMKGQADIGKLQGALGRVDNAIVYEGLNDIFEIAAKYTASIAVSHAMSDANKRTGLA
VALEYLSLNDYELVLDNELLADAVRDLVIGELTEHDFADILYAQYHLNQN

Download         Length: 393 bp

>T105597 NZ_CP029397:c2642966-2642574 [Acinetobacter defluvii]
ATGGAAATTATTTGTTTTCCATTTGAAAGAGTTATAGAAATTAATGCGTTTATTCTTTCTACTGAAAAGGGTATGAAAGG
TCAGGCTGATATTGGTAAGTTACAAGGTGCTTTGGGGCGCGTTGACAACGCTATTGTTTATGAAGGTTTGAATGACATTT
TTGAAATTGCTGCGAAATATACGGCAAGTATTGCTGTATCACATGCAATGTCTGACGCAAATAAGCGGACAGGTTTGGCA
GTTGCTTTAGAATATTTGTCATTGAATGATTATGAATTAGTCTTGGATAATGAGCTATTAGCCGATGCTGTACGTGATTT
GGTGATTGGTGAGCTAACTGAGCATGATTTTGCAGATATTTTATATGCCCAATACCATTTGAATCAAAACTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6388.56 Da        Isoelectric Point: 10.8173

>AT105597 WP_065994219.1 NZ_CP029397:c2643136-2642966 [Acinetobacter defluvii]
MNKKIEKYGVPMVERPKIQATKQLDLSGDTGKQIVKSETKLALRTHSKTFKRLADM

Download         Length: 171 bp

>AT105597 NZ_CP029397:c2643136-2642966 [Acinetobacter defluvii]
ATGAATAAGAAAATAGAAAAATATGGTGTTCCTATGGTGGAGCGTCCAAAAATCCAAGCAACCAAACAGCTTGATTTATC
TGGTGACACTGGAAAACAAATTGTAAAGTCTGAAACAAAATTAGCATTAAGAACACATTCGAAAACTTTTAAACGCTTAG
CTGATATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S2FFS8

Antitoxin

Source ID Structure
AlphaFold DB A0A2S2FG90

References