Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3699348..3700180 Replicon chromosome
Accession NZ_CP029371
Organism Escherichia coli strain C

Toxin (Protein)


Gene name yeeV Uniprot ID A0A3P5UBZ5
Locus tag DIZ83_RS19225 Protein ID WP_001094454.1
Coordinates 3699348..3699722 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A3G8RJV8
Locus tag DIZ83_RS19230 Protein ID WP_001320394.1
Coordinates 3699812..3700180 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DIZ83_RS19195 3694461..3695609 - 1149 WP_000905931.1 capsule polysaccharide export inner-membrane protein KpsE -
DIZ83_RS19200 3695681..3696664 - 984 WP_024181915.1 KpsF/GutQ family sugar-phosphate isomerase -
DIZ83_RS19205 3697475..3697645 - 171 Protein_3479 IS110 family transposase -
DIZ83_RS19210 3697988..3698557 - 570 WP_001290250.1 DUF4942 domain-containing protein -
DIZ83_RS19215 3698654..3698851 - 198 WP_000839276.1 DUF957 domain-containing protein -
DIZ83_RS19220 3698863..3699351 - 489 WP_000777545.1 hypothetical protein -
DIZ83_RS19225 3699348..3699722 - 375 WP_001094454.1 TA system toxin CbtA family protein Toxin
DIZ83_RS19230 3699812..3700180 - 369 WP_001320394.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
DIZ83_RS19235 3700230..3700873 - 644 Protein_3485 antitoxin of toxin-antitoxin stability system -
DIZ83_RS19240 3700892..3701113 - 222 WP_000692300.1 DUF987 domain-containing protein -
DIZ83_RS19245 3701176..3701652 - 477 WP_001347688.1 RadC family protein -
DIZ83_RS19250 3701668..3702153 - 486 WP_000849578.1 antirestriction protein -
DIZ83_RS19255 3702208..3703026 - 819 WP_001234644.1 DUF945 domain-containing protein -
DIZ83_RS19265 3703126..3703359 - 234 WP_001119719.1 DUF905 family protein -
DIZ83_RS19270 3703438..3703893 - 456 WP_000581493.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14059.10 Da        Isoelectric Point: 9.2447

>T105544 WP_001094454.1 NZ_CP029371:c3699722-3699348 [Escherichia coli]
MNTLPDTHVRKASRCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR

Download         Length: 375 bp

>T105544 NZ_CP029371:c3699722-3699348 [Escherichia coli]
ATGAACACATTACCCGACACACACGTACGGAAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTGTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGAAACGATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13623.22 Da        Isoelectric Point: 6.4783

>AT105544 WP_001320394.1 NZ_CP029371:c3700180-3699812 [Escherichia coli]
VSDTFSGTTHPDDNHDRPWWGLPSTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADANHLDQAFPLLMKQLELMFTSS
ELNPHRQNTVTLYAKGLTCHADTLGSCGYVYLAVYPTPETKQ

Download         Length: 369 bp

>AT105544 NZ_CP029371:c3700180-3699812 [Escherichia coli]
GTGTCAGACACATTCTCCGGGACAACTCATCCCGATGACAATCACGACCGTCCCTGGTGGGGACTACCCAGCACCGTGAC
GCCCTGTTTCGGGGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCGGATGCGAACCATCTGGACCAAGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGTTCACCAGCAGT
GAACTGAATCCCCACCGTCAGAATACCGTCACGCTGTATGCTAAAGGGCTGACCTGCCATGCGGACACCCTCGGCAGCTG
TGGTTACGTTTATCTTGCTGTTTATCCGACGCCCGAAACGAAACAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3P5UBZ5

Antitoxin

Source ID Structure
AlphaFold DB A0A3G8RJV8

References