105491

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 5136174..5136738 Replicon chromosome
Accession NZ_CP029361
Organism Streptomyces globisporus strain TFH56

Toxin (Protein)


Gene name mazF Uniprot ID A0A8B2PCB1
Locus tag DIJ69_RS23215 Protein ID WP_030801744.1
Coordinates 5136391..5136738 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID W9FME8
Locus tag DIJ69_RS23210 Protein ID WP_006124459.1
Coordinates 5136174..5136404 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DIJ69_RS23195 5132226..5132772 - 547 Protein_4538 hypothetical protein -
DIJ69_RS23200 5132918..5135494 - 2577 WP_030801748.1 aminopeptidase N -
DIJ69_RS23205 5135620..5136120 + 501 WP_044374172.1 DUF1203 domain-containing protein -
DIJ69_RS23210 5136174..5136404 + 231 WP_006124459.1 hypothetical protein Antitoxin
DIJ69_RS23215 5136391..5136738 + 348 WP_030801744.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
DIJ69_RS23220 5136812..5137840 - 1029 WP_044370813.1 aspartate-semialdehyde dehydrogenase -
DIJ69_RS23225 5138096..5141405 - 3310 Protein_4544 S8 family serine peptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12760.80 Da        Isoelectric Point: 10.9280

>T105491 WP_030801744.1 NZ_CP029361:5136391-5136738 [Streptomyces globisporus]
MRRGDIYLIDFEPVRGSEANKARPALIVSNDGANATVERLERGVLTVVPLTSNTARVFPFQVLLPADECRLAVDSKAQCE
QVRAVSPQRLKRRIGSVPLRRMADVDAALRRHLAL

Download         Length: 348 bp

>T105491 NZ_CP029361:5136391-5136738 [Streptomyces globisporus]
ATGCGGCGCGGTGACATCTATCTGATCGACTTCGAGCCGGTCCGGGGCAGTGAGGCGAACAAAGCCCGCCCGGCGCTCAT
CGTGTCGAACGACGGCGCCAACGCCACCGTGGAGCGACTGGAGCGAGGGGTGCTCACCGTGGTCCCCCTCACGTCGAACA
CGGCACGTGTCTTCCCCTTCCAGGTTCTCCTCCCGGCGGACGAGTGCCGCCTCGCGGTGGACAGCAAGGCACAGTGCGAG
CAGGTGCGTGCTGTCTCCCCCCAGCGGCTGAAGCGCCGCATCGGGTCGGTGCCCCTTCGGCGGATGGCCGATGTGGACGC
GGCGCTCAGGCGTCATCTCGCGCTCTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8285.03 Da        Isoelectric Point: 3.9251

>AT105491 WP_006124459.1 NZ_CP029361:5136174-5136404 [Streptomyces globisporus]
MKISVSLPQEDVDFVDAYAAANAAESRSAVIQAAIELLRTSRLESEYEAAFAEWDKSEDAAFWDRATGDGLTDAAR

Download         Length: 231 bp

>AT105491 NZ_CP029361:5136174-5136404 [Streptomyces globisporus]
ATGAAGATTAGTGTGAGTCTGCCGCAGGAGGATGTCGACTTCGTCGACGCCTATGCGGCCGCCAACGCCGCCGAATCGCG
GTCCGCGGTGATCCAGGCCGCGATCGAGCTGCTGCGCACCTCGCGGCTGGAGAGCGAGTACGAGGCAGCCTTCGCCGAAT
GGGACAAGAGCGAGGACGCCGCGTTCTGGGACCGTGCCACGGGCGACGGGCTGACCGATGCGGCGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B2PCB1

Antitoxin

Source ID Structure
AlphaFold DB A0A1A9D4H7

References