105490

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Fic(toxin)
Location 4761228..4761793 Replicon chromosome
Accession NZ_CP029361
Organism Streptomyces globisporus strain TFH56

Toxin (Protein)


Gene name doc Uniprot ID A0A1Q5BHK1
Locus tag DIJ69_RS21595 Protein ID WP_044373775.1
Coordinates 4761425..4761793 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A1Q5BHI7
Locus tag DIJ69_RS21590 Protein ID WP_044373773.1
Coordinates 4761228..4761425 (+) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DIJ69_RS21560 4756605..4757108 + 504 WP_128862769.1 hypothetical protein -
DIJ69_RS21565 4757182..4757829 + 648 WP_044373769.1 hypothetical protein -
DIJ69_RS21570 4758132..4758497 + 366 WP_172593887.1 hypothetical protein -
DIJ69_RS21575 4758562..4759329 + 768 WP_044373771.1 hypothetical protein -
DIJ69_RS21585 4759681..4761192 + 1512 WP_030802545.1 MFS transporter -
DIJ69_RS21590 4761228..4761425 + 198 WP_044373773.1 Arc family DNA-binding protein Antitoxin
DIJ69_RS21595 4761425..4761793 + 369 WP_044373775.1 Fic family protein Toxin
DIJ69_RS21600 4761963..4763747 + 1785 WP_032793775.1 DEAD/DEAH box helicase -
DIJ69_RS21605 4764232..4764876 + 645 WP_006124906.1 helix-turn-helix domain-containing protein -
DIJ69_RS21610 4765030..4765818 + 789 WP_044373779.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4753695..4769935 16240


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(12-118)

Antitoxin

Arc-like DNA binding domain

(5-28)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13640.55 Da        Isoelectric Point: 4.5341

>T105490 WP_044373775.1 NZ_CP029361:4761425-4761793 [Streptomyces globisporus]
MQYLTLPELLNLTERLGTPEVRDYGLLESALARPQASVFGQDAYPDVWQKAAALMESLARNHGLVDGNKRIAWFATWVFL
HMNGHPLDAGFDVDEAERFVPAVCQGALDMPKIAEQLPEFAR

Download         Length: 369 bp

>T105490 NZ_CP029361:4761425-4761793 [Streptomyces globisporus]
ATGCAGTACCTGACCCTGCCCGAGCTGCTGAACCTGACGGAGCGGCTCGGCACGCCGGAGGTACGCGACTACGGGCTGCT
GGAATCCGCGCTGGCCCGGCCACAGGCGAGCGTGTTCGGCCAGGACGCCTATCCGGATGTCTGGCAGAAGGCCGCGGCCC
TCATGGAGTCCCTAGCCCGGAACCACGGGCTCGTGGACGGCAACAAGCGGATCGCGTGGTTCGCGACCTGGGTGTTCCTC
CACATGAACGGCCATCCGCTCGACGCCGGCTTCGACGTCGACGAAGCGGAGCGGTTCGTGCCGGCGGTGTGCCAGGGCGC
TCTGGACATGCCCAAGATCGCCGAACAGTTGCCGGAGTTCGCTCGGTAG

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7309.13 Da        Isoelectric Point: 4.7860

>AT105490 WP_044373773.1 NZ_CP029361:4761228-4761425 [Streptomyces globisporus]
MAGLNLRFTEEELDSLRARAEAEGRSMQAFAHDAVITAVNEHSRLFDEAADHVLKVSEELNRRLA

Download         Length: 198 bp

>AT105490 NZ_CP029361:4761228-4761425 [Streptomyces globisporus]
ATGGCTGGTCTGAATCTGCGGTTCACCGAGGAAGAGCTGGACTCCCTGCGCGCCCGCGCCGAGGCGGAGGGGAGGAGCAT
GCAGGCGTTCGCCCACGATGCGGTGATCACTGCCGTAAACGAGCACTCCCGGCTCTTCGACGAGGCCGCGGACCACGTGC
TGAAGGTCAGTGAGGAGCTCAACCGGAGGCTTGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q5BHK1

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q5BHI7

References