Detailed information of TA system TA105473

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 4542598..4543120
• Replicon: chromosome
• Accession: NZ_CP029342
• Organism: Streptomyces sp. SM18

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: B9S64_RS20670
• Protein ID: WP_103490058.1
• Coordinates: 4542598..4542861 (-)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: B9S64_RS20675
• Protein ID: WP_103490059.1
• Coordinates: 4542854..4543120 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B9S64_RS20645	4537835..4538317	-	483	WP_028439143.1	succinate dehydrogenase hydrophobic membrane anchor subunit	-
B9S64_RS20650	4538323..4538703	-	381	WP_014047903.1	succinate dehydrogenase, cytochrome b556 subunit	-
B9S64_RS20655	4538896..4539369	-	474	WP_103490062.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
B9S64_RS20660	4540095..4541708	+	1614	WP_103490056.1	family 20 glycosylhydrolase	-
B9S64_RS20665	4541975..4542553	+	579	WP_103490057.1	hypothetical protein	-
B9S64_RS20670	4542598..4542861	-	264	WP_103490058.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
B9S64_RS20675	4542854..4543120	-	267	WP_103490059.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
B9S64_RS20680	4543491..4544174	+	684	WP_103490060.1	RNA polymerase sigma factor	-
B9S64_RS20685	4544174..4545274	+	1101	WP_103490061.1	hypothetical protein	-
B9S64_RS20690	4545492..4546430	-	939	WP_109492085.1	L,D-transpeptidase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (6-57)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 9992.40 Da
• Isoelectric Point: 7.9968

>T105473 WP_103490058.1 NZ_CP029342:c4542861-4542598 [Streptomyces sp. SM18]
VSEYRTVFRPEAQAELRKIPRDAALRILTKLTELEADPLGFNSTSLVSQPDCRRLRVGDYRVIYTIDNGELVVWVVRVGH
RSTVYDT

Nucleotide

• Length: 264 bp

>T105473 NZ_CP029342:c4542861-4542598 [Streptomyces sp. SM18]
GTGAGTGAATATCGCACTGTCTTCCGACCTGAGGCCCAAGCCGAGCTTCGCAAGATCCCGAGGGACGCGGCCCTCCGCAT
TCTGACCAAGCTGACCGAGCTGGAGGCCGACCCGCTCGGGTTCAACAGCACGTCCCTCGTGTCCCAGCCCGACTGCCGCC
GCCTACGGGTGGGCGACTACCGCGTGATCTACACGATCGACAACGGCGAACTGGTGGTATGGGTGGTCCGCGTCGGACAC
CGCTCCACCGTCTACGACACCTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10138.55 Da
• Isoelectric Point: 4.6069

>AT105473 WP_103490059.1 NZ_CP029342:c4543120-4542854 [Streptomyces sp. SM18]
MTQMPIESIRDVRAHLADVVERADRDDVPTVITRRGKQVAAVVSIEVLRKYQEWEEREINRIIDERMADPAPGVPIEDVM
RETLARGE

Nucleotide

• Length: 267 bp

>AT105473 NZ_CP029342:c4543120-4542854 [Streptomyces sp. SM18]
ATGACGCAGATGCCCATAGAGTCCATCCGCGATGTCCGCGCCCACCTGGCGGACGTGGTCGAGCGGGCCGACCGGGACGA
CGTGCCCACCGTGATCACCCGACGCGGCAAGCAGGTCGCCGCTGTCGTCTCCATCGAGGTCCTGCGCAAGTATCAGGAGT
GGGAAGAGCGCGAGATCAACCGGATCATCGACGAGCGCATGGCCGACCCCGCGCCCGGCGTCCCGATCGAGGACGTCATG
AGGGAGACGTTGGCACGCGGTGAGTGA