Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 135826..136508 Replicon plasmid pMAC109a
Accession NZ_CP029333
Organism Mycobacterium avium subsp. hominissuis strain MAC109

Toxin (Protein)


Gene name vapC Uniprot ID A0A854IDQ2
Locus tag DFS55_RS25300 Protein ID WP_040624374.1
Coordinates 136092..136508 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID D5P579
Locus tag DFS55_RS25295 Protein ID WP_007172349.1
Coordinates 135826..136089 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DFS55_RS25270 131144..131815 - 672 WP_141244939.1 C40 family peptidase -
DFS55_RS25275 131881..133121 + 1241 WP_095786034.1 IS3 family transposase -
DFS55_RS25285 133583..134686 - 1104 WP_051404593.1 hypothetical protein -
DFS55_RS25290 134750..135724 - 975 WP_023363505.1 hypothetical protein -
DFS55_RS25295 135826..136089 + 264 WP_007172349.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
DFS55_RS25300 136092..136508 + 417 WP_040624374.1 type II toxin-antitoxin system VapC family toxin Toxin
DFS55_RS25305 136790..137392 - 603 Protein_143 IS256 family transposase -
DFS55_RS25310 137441..139054 - 1614 WP_040624461.1 hypothetical protein -
DFS55_RS25315 139057..139374 - 318 WP_007172532.1 helix-turn-helix transcriptional regulator -
DFS55_RS25320 139377..140429 - 1053 WP_007172533.1 site-specific integrase -
DFS55_RS25325 140574..141302 - 729 Protein_147 IS256 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - eccA5 / esxN 1..147100 147100


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-125)

Antitoxin

Antitoxin VapB-like

(1-82)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14879.84 Da        Isoelectric Point: 5.4519

>T105471 WP_040624374.1 NZ_CP029333:136092-136508 [Mycobacterium avium subsp. hominissuis]
MIIDSSAIVALIQGEDPYTEQIAAAIAADPSPVMSTANAAECLIVLTNRHGATARTVFDRLRSEINLGFQPFTLEHAIAA
HRAYLHYGKGRHPAALNYGDTMAYATAKLAHEPLIAIGNDFTQTDLEFNGVIGYWPAP

Download         Length: 417 bp

>T105471 NZ_CP029333:136092-136508 [Mycobacterium avium subsp. hominissuis]
CTGATCATCGACTCTTCCGCGATCGTCGCCCTCATCCAGGGCGAGGACCCCTACACCGAACAGATCGCGGCCGCCATCGC
CGCCGATCCCAGCCCCGTCATGTCCACGGCCAACGCAGCCGAATGCCTCATCGTTCTCACCAACCGACACGGCGCGACCG
CGCGCACCGTCTTCGACCGCCTACGATCCGAAATCAACCTCGGCTTCCAGCCCTTCACCCTCGAACACGCGATCGCCGCC
CACCGCGCCTACCTCCACTACGGAAAAGGCCGCCACCCCGCCGCCCTCAACTACGGCGACACCATGGCCTACGCCACCGC
CAAACTCGCACACGAACCCCTCATCGCCATCGGCAACGACTTCACCCAAACCGACCTCGAATTCAACGGCGTCATCGGCT
ACTGGCCAGCGCCCTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9884.20 Da        Isoelectric Point: 4.8359

>AT105471 WP_007172349.1 NZ_CP029333:135826-136089 [Mycobacterium avium subsp. hominissuis]
MAFNVKDEEVIRFADELAARLHLPSRIDAIRYALRAQIEVTQSRTANRSAELLDVLKTEIWPLLDDRSPITKTEREQALG
YDTATGV

Download         Length: 264 bp

>AT105471 NZ_CP029333:135826-136089 [Mycobacterium avium subsp. hominissuis]
ATGGCTTTCAACGTGAAAGACGAAGAGGTCATCCGCTTCGCAGACGAGCTCGCCGCGCGCCTCCACCTCCCCAGCCGCAT
CGACGCCATCCGCTACGCCCTGCGAGCCCAGATCGAAGTCACCCAATCCCGCACCGCAAACCGCTCCGCAGAACTGCTCG
ACGTCCTCAAAACCGAGATCTGGCCACTACTGGACGACCGATCCCCAATCACCAAAACCGAACGCGAACAAGCCCTCGGA
TACGACACAGCAACGGGAGTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A854IDQ2

Antitoxin

Source ID Structure
AlphaFold DB A0A1Y0TBQ2

References