Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YoeB-YefM
Location 19565..20103 Replicon plasmid pMAC109a
Accession NZ_CP029333
Organism Mycobacterium avium subsp. hominissuis strain MAC109

Toxin (Protein)


Gene name relE Uniprot ID D5P5D7
Locus tag DFS55_RS24690 Protein ID WP_007172405.1
Coordinates 19846..20103 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID M1FTM7
Locus tag DFS55_RS24685 Protein ID WP_007172404.1
Coordinates 19565..19849 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DFS55_RS24665 14698..16218 - 1521 WP_007172379.1 DUF4226 domain-containing protein -
DFS55_RS24670 16440..17333 - 894 WP_052742716.1 DUF2637 domain-containing protein -
DFS55_RS24675 18024..18719 + 696 WP_007172400.1 ParA family protein -
DFS55_RS25835 18722..19483 + 762 WP_023363524.1 hypothetical protein -
DFS55_RS24685 19565..19849 + 285 WP_007172404.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
DFS55_RS24690 19846..20103 + 258 WP_007172405.1 Txe/YoeB family addiction module toxin Toxin
DFS55_RS24695 20318..20611 - 294 WP_007172406.1 hypothetical protein -
DFS55_RS24700 20628..21626 - 999 WP_101930848.1 hypothetical protein -
DFS55_RS24705 22338..22907 + 570 WP_007172408.1 hypothetical protein -
DFS55_RS24710 22897..23997 + 1101 WP_007172409.1 tyrosine-type recombinase/integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - eccA5 / esxN 1..147100 147100


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-70)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10156.56 Da        Isoelectric Point: 9.8613

>T105470 WP_007172405.1 NZ_CP029333:19846-20103 [Mycobacterium avium subsp. hominissuis]
VRSINFDPAAWEDFLFWLASDRKTARRITRLIAEIQRNPFAGIGKPEPLKGELSGYWSRRIDDEHRIVYRADDHEIKILK
ARYHY

Download         Length: 258 bp

>T105470 NZ_CP029333:19846-20103 [Mycobacterium avium subsp. hominissuis]
GTGAGAAGCATCAACTTCGATCCCGCCGCGTGGGAGGACTTTCTATTTTGGCTGGCTTCCGACCGCAAAACAGCACGGCG
CATCACCAGACTCATCGCAGAAATCCAGCGCAACCCGTTTGCTGGGATTGGAAAACCAGAACCGCTCAAGGGTGAACTAT
CCGGGTACTGGTCGCGGCGCATCGACGACGAACACCGGATCGTCTACCGCGCAGATGATCACGAAATCAAGATCCTCAAA
GCCCGATACCACTACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10455.62 Da        Isoelectric Point: 4.3885

>AT105470 WP_007172404.1 NZ_CP029333:19565-19849 [Mycobacterium avium subsp. hominissuis]
MAISASEARQRLFPLLEQVNTDHEPVRITSKAGDAVLMSAADYDSWQETVYLLRSPENARRLMEAVARDNATRPTPGSYT
KSIDELEEMAGGQE

Download         Length: 285 bp

>AT105470 NZ_CP029333:19565-19849 [Mycobacterium avium subsp. hominissuis]
ATGGCTATCAGTGCAAGTGAGGCCCGGCAGCGCCTCTTTCCGCTGCTTGAACAAGTCAACACCGACCACGAGCCTGTGCG
AATTACGTCCAAGGCCGGAGATGCAGTGCTCATGTCGGCCGCTGACTACGATTCGTGGCAAGAAACGGTCTACCTCCTGC
GTTCCCCCGAGAATGCCCGCCGACTCATGGAGGCCGTCGCCCGAGACAACGCCACCCGGCCCACCCCCGGCAGCTACACC
AAGTCGATCGACGAACTCGAGGAGATGGCCGGCGGCCAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Y0THX2

Antitoxin

Source ID Structure
AlphaFold DB M1FTM7

References