Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 4622..5163 Replicon plasmid pMAC109a
Accession NZ_CP029333
Organism Mycobacterium avium subsp. hominissuis strain MAC109

Toxin (Protein)


Gene name parE Uniprot ID D5P595
Locus tag DFS55_RS24605 Protein ID WP_007172365.1
Coordinates 4622..4915 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A854I1S2
Locus tag DFS55_RS24610 Protein ID WP_040624378.1
Coordinates 4912..5163 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DFS55_RS25820 614..886 - 273 WP_139315440.1 hypothetical protein -
DFS55_RS25825 1010..1681 - 672 WP_139315441.1 hypothetical protein -
DFS55_RS24595 1791..2870 - 1080 WP_007172361.1 hypothetical protein -
DFS55_RS25830 2985..3683 - 699 WP_139315442.1 hypothetical protein -
DFS55_RS24600 3697..4137 - 441 WP_157137591.1 hypothetical protein -
DFS55_RS24605 4622..4915 - 294 WP_007172365.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DFS55_RS24610 4912..5163 - 252 WP_040624378.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
DFS55_RS24615 5269..5775 - 507 WP_007172367.1 helix-turn-helix domain-containing protein -
DFS55_RS24620 6082..6519 + 438 WP_007172368.1 WhiB family transcriptional regulator -
DFS55_RS24625 7128..7412 + 285 WP_007172369.1 hypothetical protein -
DFS55_RS24630 7789..9651 + 1863 WP_023363516.1 helicase associated domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - eccA5 / esxN 1..147100 147100


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin

Antitoxin ParD

(2-79)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11261.74 Da        Isoelectric Point: 6.9772

>T105469 WP_007172365.1 NZ_CP029333:c4915-4622 [Mycobacterium avium subsp. hominissuis]
VSAYVLSPAAQADLEQIWDYTHEHWGLDQAEQYLRELQRAIERAAANPRIGRACDEIRPGYRKLAAGSHMLFYRVTTQGF
LDVVRVLHQRMDVDRHL

Download         Length: 294 bp

>T105469 NZ_CP029333:c4915-4622 [Mycobacterium avium subsp. hominissuis]
GTGAGCGCATACGTCCTTTCACCCGCTGCGCAAGCAGATTTGGAACAGATCTGGGACTACACGCACGAGCACTGGGGCCT
GGATCAGGCTGAGCAGTACCTGCGAGAACTTCAACGCGCTATCGAGCGCGCAGCGGCGAACCCCCGGATCGGGCGGGCCT
GCGACGAGATCCGCCCGGGCTATCGCAAGCTGGCAGCCGGGTCGCACATGCTGTTTTATCGGGTGACAACCCAAGGCTTC
CTCGATGTCGTGCGTGTCCTGCACCAACGCATGGACGTCGACCGCCACCTTTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9203.22 Da        Isoelectric Point: 5.8579

>AT105469 WP_040624378.1 NZ_CP029333:c5163-4912 [Mycobacterium avium subsp. hominissuis]
VGKNTSFSLDEHYSAFIEAEVAAGRYRSASDVVRSALRLLEDREIQLRALREALVAGERSGTSTPFDFDAFLDGKRAEKP
QGR

Download         Length: 252 bp

>AT105469 NZ_CP029333:c5163-4912 [Mycobacterium avium subsp. hominissuis]
GTGGGTAAAAACACGTCCTTCAGTCTCGATGAGCATTACAGCGCCTTCATTGAGGCTGAGGTGGCTGCGGGACGTTACCG
GTCGGCCAGTGATGTCGTGCGCTCCGCGTTGCGGTTACTCGAGGACCGTGAAATTCAGCTTCGGGCACTGCGCGAGGCGC
TAGTGGCCGGTGAGCGCAGCGGCACTTCAACACCGTTTGACTTCGACGCCTTCCTCGACGGCAAACGCGCCGAAAAGCCG
CAAGGCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Y0TBP0

Antitoxin

Source ID Structure
AlphaFold DB A0A854I1S2

References