Detailed information of TA system TA105467

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 4125846..4126410
• Replicon: chromosome
• Accession: NZ_CP029332
• Organism: Mycobacterium avium subsp. hominissuis strain MAC109

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A3B6XBP4
• Locus tag: DFS55_RS19200
• Protein ID: WP_062889694.1
• Coordinates: 4125846..4126217 (-)
• Length: 124 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: DFS55_RS19205
• Protein ID: WP_023865347.1
• Coordinates: 4126204..4126410 (-)
• Length: 69 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DFS55_RS19155	4121164..4121361	-	198	WP_009975398.1	hypothetical protein	-
DFS55_RS19160	4121479..4122162	+	684	WP_009975397.1	hypothetical protein	-
DFS55_RS19165	4122167..4122490	-	324	WP_009975396.1	antibiotic biosynthesis monooxygenase	-
DFS55_RS19170	4122893..4123441	-	549	WP_080516335.1	glycoside hydrolase	-
DFS55_RS19175	4123598..4123951	-	354	WP_023868521.1	hypothetical protein	-
DFS55_RS19180	4124021..4124404	-	384	WP_023868520.1	hypothetical protein	-
DFS55_RS19185	4124473..4124871	-	399	WP_023865349.1	VOC family protein	-
DFS55_RS19190	4124973..4125248	-	276	WP_033718665.1	hypothetical protein	-
DFS55_RS19195	4125306..4125746	-	441	WP_003875392.1	nitroreductase family deazaflavin-dependent oxidoreductase	-
DFS55_RS19200	4125846..4126217	-	372	WP_062889694.1	type II toxin-antitoxin system VapC family toxin	Toxin
DFS55_RS19205	4126204..4126410	-	207	WP_023865347.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
DFS55_RS19210	4126578..4127522	-	945	WP_062889691.1	HNH endonuclease	-
DFS55_RS19215	4127722..4128795	-	1074	WP_033710961.1	redox-regulated ATPase YchF	-
DFS55_RS19220	4128926..4130134	+	1209	WP_179295679.1	hypothetical protein	-
DFS55_RS19225	4130158..4131156	-	999	WP_023868514.1	4-hydroxy-3-methylbut-2-enyl diphosphate reductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (2-42)

Sequences

Toxin

Protein

• Length: 124 a.a.
• Molecular weight: 13796.22 Da
• Isoelectric Point: 6.6003

>T105467 WP_062889694.1 NZ_CP029332:c4126217-4125846 [Mycobacterium avium subsp. hominissuis]
MILVDTLVWIDHLHVADKRLIEFLTNDAIGCHQMVIEELALGAIRRRADLLRLLSNLRAFPLLTHAEVLHLVECHRLWGR
GLSAIDVHLLGSVALVDGARLWTRDKNLKAAGWDVGIAIVDEL

Nucleotide

• Length: 372 bp

>T105467 NZ_CP029332:c4126217-4125846 [Mycobacterium avium subsp. hominissuis]
ATGATTCTCGTTGACACGTTGGTATGGATCGATCATCTGCACGTCGCCGACAAGCGACTCATAGAGTTCCTGACCAACGA
CGCAATCGGTTGCCACCAAATGGTGATCGAGGAGTTGGCATTGGGTGCGATCAGGCGGCGCGCCGATCTATTGCGCCTGC
TGTCCAATCTTCGGGCGTTCCCGTTGCTGACGCATGCGGAGGTCCTTCATCTCGTCGAATGCCACCGCTTGTGGGGCCGC
GGACTGAGTGCGATCGACGTCCATCTTCTCGGGTCGGTTGCTCTGGTCGACGGTGCACGGCTATGGACCAGGGACAAGAA
TTTAAAAGCGGCGGGCTGGGACGTGGGTATCGCGATCGTCGACGAGCTCTGA

Antitoxin

Protein

• Length: 69 a.a.
• Molecular weight: 7314.30 Da
• Isoelectric Point: 11.5657

>AT105467 WP_023865347.1 NZ_CP029332:c4126410-4126204 [Mycobacterium avium subsp. hominissuis]
VRTTVTIDDALLREAAELTGVTESVALLRQGLQTLVRVESARRLAALGGTDRKASVGPRRRTPADDSR

Nucleotide

• Length: 207 bp

>AT105467 NZ_CP029332:c4126410-4126204 [Mycobacterium avium subsp. hominissuis]
GTGAGGACGACGGTGACGATTGACGACGCCTTATTGAGAGAGGCGGCCGAACTGACCGGGGTGACAGAGAGCGTGGCGCT
CCTCCGTCAGGGACTGCAGACACTCGTTCGGGTAGAGAGCGCCCGTCGGCTGGCGGCGCTCGGCGGCACGGATCGGAAGG
CATCGGTCGGCCCTCGCCGGAGGACACCCGCCGATGATTCTCGTTGA

Structures

Toxin

• AlphaFold DB: A0A3B6XBP4