Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-PHD
Location 3269852..3270513 Replicon chromosome
Accession NZ_CP029332
Organism Mycobacterium avium subsp. hominissuis strain MAC109

Toxin (Protein)


Gene name vapC Uniprot ID A0A049E7F1
Locus tag DFS55_RS15390 Protein ID WP_023879930.1
Coordinates 3269852..3270256 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A049EBE1
Locus tag DFS55_RS15395 Protein ID WP_009976405.1
Coordinates 3270253..3270513 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DFS55_RS15370 3265487..3265816 + 330 Protein_3016 protein kinase -
DFS55_RS15375 3265884..3267116 - 1233 WP_011725525.1 IS256-like element IS1245 family transposase -
DFS55_RS15380 3267235..3268242 + 1008 Protein_3018 serine/threonine protein kinase -
DFS55_RS15385 3268219..3269523 - 1305 WP_011724019.1 IS256-like element IS666 family transposase -
DFS55_RS15390 3269852..3270256 - 405 WP_023879930.1 type II toxin-antitoxin system VapC family toxin Toxin
DFS55_RS15395 3270253..3270513 - 261 WP_009976405.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
DFS55_RS15400 3270694..3271146 - 453 WP_024637372.1 VOC family protein -
DFS55_RS25620 3271312..3271458 + 147 WP_155267604.1 hypothetical protein -
DFS55_RS15405 3271481..3272742 + 1262 WP_085989547.1 IS3 family transposase -
DFS55_RS15410 3272776..3273930 + 1155 Protein_3025 cytochrome P450 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 3265884..3272742 6858


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-124)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-64)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14329.33 Da        Isoelectric Point: 4.5860

>T105466 WP_023879930.1 NZ_CP029332:c3270256-3269852 [Mycobacterium avium subsp. hominissuis]
MTARPAGVLDTSVFIASESGRHLDEARIPDEVATTVITLAELHAGVLAATTSDVRAQRLATLESIADMEMLPVDDDAARM
WARLRIHLAEAGRRMRANDLWIAGIAASRGLPVVTQDDDFAALDGAANLAIIRV

Download         Length: 405 bp

>T105466 NZ_CP029332:c3270256-3269852 [Mycobacterium avium subsp. hominissuis]
ATGACTGCAAGGCCGGCCGGGGTGCTCGACACCTCGGTGTTCATCGCGTCCGAAAGCGGACGGCACCTGGACGAGGCGCG
AATCCCCGACGAGGTAGCCACCACCGTCATCACCCTTGCCGAACTTCACGCCGGCGTATTAGCCGCGACGACGTCCGACG
TTCGGGCGCAACGCCTCGCAACGCTGGAATCGATAGCGGATATGGAAATGTTGCCAGTCGACGACGACGCGGCCCGCATG
TGGGCAAGGTTGCGGATCCACCTAGCCGAGGCTGGACGGCGGATGCGGGCTAATGATCTGTGGATCGCGGGGATCGCGGC
ATCGCGGGGACTGCCCGTTGTCACCCAGGATGACGACTTCGCCGCACTCGACGGCGCGGCGAACCTGGCGATTATTCGGG
TTTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9495.81 Da        Isoelectric Point: 11.4633

>AT105466 WP_009976405.1 NZ_CP029332:c3270513-3270253 [Mycobacterium avium subsp. hominissuis]
MSEVASRELRNDTAGVLRRVREGEDVTITVNGRAVAMLTALGPQRRRWLSKAELLSRLRRAQADPGLRQDLATLAGDTTE
DLGPIR

Download         Length: 261 bp

>AT105466 NZ_CP029332:c3270513-3270253 [Mycobacterium avium subsp. hominissuis]
ATGTCTGAAGTGGCGTCTCGCGAGCTGCGCAACGATACGGCGGGGGTACTGCGGCGCGTGCGGGAAGGGGAGGACGTCAC
CATCACCGTCAACGGCCGAGCCGTCGCGATGCTGACCGCGCTGGGGCCGCAGCGACGGCGGTGGCTGAGCAAGGCGGAGT
TGCTGTCGCGCTTGCGCCGCGCGCAAGCCGATCCCGGGCTACGCCAAGACCTCGCAACCCTTGCAGGCGACACAACTGAG
GACCTCGGTCCGATCCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A049E7F1

Antitoxin

Source ID Structure
AlphaFold DB A0A049EBE1

References