Detailed information of TA system TA105465

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/ParD(antitoxin)
• Location: 2953094..2954092
• Replicon: chromosome
• Accession: NZ_CP029332
• Organism: Mycobacterium avium subsp. hominissuis strain MAC109

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: A0A3B6X8G6
• Locus tag: DFS55_RS13995
• Protein ID: WP_062889564.1
• Coordinates: 2953094..2953672 (-)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: A0A3B6XDY0
• Locus tag: DFS55_RS14000
• Protein ID: WP_062889596.1
• Coordinates: 2953703..2954092 (-)
• Length: 130 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DFS55_RS13970	2949086..2950018	-	933	WP_062889570.1	sigma-70 family RNA polymerase sigma factor	-
DFS55_RS13975	2950187..2950537	+	351	WP_003878038.1	DoxX family protein	-
DFS55_RS13980	2950551..2951351	-	801	WP_062889568.1	nuclear transport factor 2 family protein	-
DFS55_RS13985	2951351..2951911	-	561	WP_155726728.1	pyrazinamidase PncA	-
DFS55_RS13990	2952022..2953089	+	1068	WP_062889566.1	DoxX family membrane protein	-
DFS55_RS13995	2953094..2953672	-	579	WP_062889564.1	zeta toxin family protein	Toxin
DFS55_RS14000	2953703..2954092	-	390	WP_062889596.1	hypothetical protein	Antitoxin
DFS55_RS14005	2954173..2954667	-	495	WP_062889562.1	gluconokinase	-
DFS55_RS14010	2954664..2956661	-	1998	WP_062889560.1	phosphotransferase	-
DFS55_RS14015	2956680..2958197	-	1518	WP_023865875.1	carboxylesterase/lipase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (5-136)

Antitoxin

• ParD-like antitoxin of type II bacterial toxin-antitoxin system (6-106)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 20991.16 Da
• Isoelectric Point: 10.4235

>T105465 WP_062889564.1 NZ_CP029332:c2953672-2953094 [Mycobacterium avium subsp. hominissuis]
MERLDVVVGPNGAGKSTFIALTLAPLLPGSVVVNADEIARQRWPQDPASHAYDAAKVAADTRAKLIDLGRSFIAETVFSH
PSKLDLLHAARRAGFTVVLHVLLIPEDLAVERVRHRVRAGGHDVPETKIRERHRRLWTPVAEAMTLADLATGYDNSRLRG
PRVVARLSGGLTVGAVDWPAWAPETLRSLWPV

Nucleotide

• Length: 579 bp

>T105465 NZ_CP029332:c2953672-2953094 [Mycobacterium avium subsp. hominissuis]
ATGGAGCGACTCGACGTGGTGGTCGGGCCCAACGGCGCCGGCAAGTCGACGTTCATCGCGTTGACCCTGGCGCCGCTGCT
GCCGGGCAGCGTGGTGGTCAACGCCGACGAGATCGCGCGGCAGCGCTGGCCGCAGGATCCGGCGTCGCACGCCTACGACG
CCGCGAAGGTCGCCGCCGACACCCGGGCGAAGCTGATCGACCTGGGCCGGTCGTTCATCGCCGAGACCGTGTTCTCCCAT
CCGTCCAAGCTGGACCTGCTGCACGCCGCCCGCCGCGCCGGCTTCACCGTCGTGCTGCACGTGCTGCTCATCCCGGAAGA
CCTTGCCGTCGAACGGGTCCGGCACCGCGTGCGGGCCGGCGGCCATGACGTGCCGGAAACCAAGATCCGCGAGCGGCATC
GCCGGTTGTGGACTCCGGTCGCCGAGGCGATGACCCTGGCCGACCTGGCCACCGGCTACGACAACAGCCGGCTGCGCGGG
CCGCGTGTGGTGGCCCGGCTCAGCGGCGGGCTGACGGTCGGTGCCGTCGACTGGCCGGCGTGGGCACCCGAGACCTTGCG
GTCGCTTTGGCCGGTCTAA

Antitoxin

Protein

• Length: 130 a.a.
• Molecular weight: 13599.03 Da
• Isoelectric Point: 5.2145

>AT105465 WP_062889596.1 NZ_CP029332:c2954092-2953703 [Mycobacterium avium subsp. hominissuis]
MAEAVDRVTRVASDLMDSAAAEGARQSRSAKQQLDHWARVGRAVSSQHTASRRRVEAALAGRLSTAELTVEEGVVFNAEI
SAAIDESLARTDYGATLAGQGVTTVALNDDGEIVEHRPDGTAVVLAGRR

Nucleotide

• Length: 390 bp

>AT105465 NZ_CP029332:c2954092-2953703 [Mycobacterium avium subsp. hominissuis]
ATGGCCGAGGCCGTCGATCGGGTCACCCGGGTCGCGTCCGATCTGATGGACAGCGCGGCGGCCGAGGGCGCCCGTCAGAG
CCGCTCGGCTAAGCAGCAGCTCGACCACTGGGCGCGGGTCGGGCGTGCGGTGTCCAGCCAGCACACCGCGTCCCGGCGGC
GGGTCGAAGCCGCGCTGGCCGGCCGGCTGTCCACCGCCGAACTCACCGTCGAAGAGGGCGTGGTGTTCAACGCCGAGATC
TCGGCGGCCATCGACGAAAGCCTGGCGCGCACCGACTACGGGGCGACGCTGGCCGGGCAGGGTGTCACCACGGTGGCCCT
CAACGACGACGGCGAGATCGTCGAGCACCGGCCCGACGGCACCGCGGTGGTGCTGGCCGGCCGGCGCTGA

Structures

Toxin

• AlphaFold DB: A0A3B6X8G6

Antitoxin

• AlphaFold DB: A0A3B6XDY0