Detailed information of TA system TA105463

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicA
• Location: 1166847..1167294
• Replicon: chromosome
• Accession: NZ_CP029331
• Organism: Thauera hydrothermalis strain GD-2

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: DIE29_RS05700
• Protein ID: WP_108080270.1
• Coordinates: 1167106..1167294 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: DIE29_RS05695
• Protein ID: WP_108080271.1
• Coordinates: 1166847..1167101 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DIE29_RS05660	1162012..1162308	-	297	WP_114649444.1	helix-turn-helix domain-containing protein	-
DIE29_RS05665	1162686..1163909	+	1224	WP_102042001.1	aspartate kinase	-
DIE29_RS05675	1164310..1165436	+	1127	Protein_1110	IS3 family transposase	-
DIE29_RS05680	1165553..1166275	-	723	WP_108080272.1	hypothetical protein	-
DIE29_RS05685	1166309..1166587	-	279	WP_205409785.1	DUF2442 domain-containing protein	-
DIE29_RS05690	1166580..1166819	-	240	WP_108080261.1	DUF4160 domain-containing protein	-
DIE29_RS05695	1166847..1167101	-	255	WP_108080271.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
DIE29_RS05700	1167106..1167294	-	189	WP_108080270.1	type II toxin-antitoxin system HicA family toxin	Toxin
DIE29_RS05710	1167760..1168893	+	1134	WP_102040763.1	ISAs1 family transposase	-
DIE29_RS05715	1169198..1170424	+	1227	WP_108080269.1	ISL3 family transposase	-
DIE29_RS05720	1170587..1171435	-	849	Protein_1118	IS630 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	IScluster/Tn	-	-	1164310..1176435	12125

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-60)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-66)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 6642.75 Da
• Isoelectric Point: 11.3688

>T105463 WP_108080270.1 NZ_CP029331:c1167294-1167106 [Thauera hydrothermalis]
MKVGDVLLMLRNDGWFLVATRGSHRQFKHPSKPGRVTVAGKPSDDLAAGTLNSILKQAGLKG

Nucleotide

• Length: 189 bp

>T105463 NZ_CP029331:c1167294-1167106 [Thauera hydrothermalis]
ATGAAAGTCGGTGACGTGTTGCTCATGCTCCGCAACGATGGCTGGTTCCTGGTGGCGACTCGGGGAAGTCACCGCCAGTT
CAAGCATCCATCCAAACCTGGGCGTGTCACCGTTGCAGGGAAACCGAGTGATGATTTGGCAGCCGGAACACTCAACAGCA
TTCTCAAGCAGGCAGGACTGAAAGGGTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 8816.89 Da
• Isoelectric Point: 3.9484

>AT105463 WP_108080271.1 NZ_CP029331:c1167101-1166847 [Thauera hydrothermalis]
MRYAIVIERAGNNFSGYVPDLPGCVATGATVEETETELLSAIQFHLEGLREDGVAAPAAESIVEYVFVPAQPCAPGDAPQ
AARP

Nucleotide

• Length: 255 bp

>AT105463 NZ_CP029331:c1167101-1166847 [Thauera hydrothermalis]
ATGCGCTATGCAATCGTGATTGAAAGGGCAGGCAATAATTTTTCTGGTTATGTGCCCGATTTGCCCGGCTGTGTCGCAAC
CGGGGCGACCGTGGAGGAAACCGAAACCGAGCTGCTTTCGGCCATCCAGTTTCACCTCGAGGGCCTACGCGAGGACGGAG
TTGCCGCACCTGCTGCGGAAAGCATCGTCGAGTATGTGTTTGTTCCTGCCCAACCCTGCGCTCCAGGGGACGCGCCGCAA
GCGGCGCGCCCCTGA