Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 943031..944063 Replicon chromosome
Accession NZ_CP029331
Organism Thauera hydrothermalis strain GD-2

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag DIE29_RS04590 Protein ID WP_114649340.1
Coordinates 943491..944063 (+) Length 191 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID -
Locus tag DIE29_RS04585 Protein ID WP_114649339.1
Coordinates 943031..943486 (+) Length 152 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DIE29_RS04550 938451..939263 + 813 WP_108080418.1 IS21-like element helper ATPase IstB -
DIE29_RS04555 939339..939806 - 468 WP_114649337.1 hypothetical protein -
DIE29_RS04560 939818..940450 - 633 WP_108080416.1 hypothetical protein -
DIE29_RS04565 940454..941272 - 819 WP_108080415.1 ATP-binding protein -
DIE29_RS04570 941272..942042 - 771 WP_108080414.1 Bro-N domain-containing protein -
DIE29_RS04575 942046..942525 - 480 WP_102043238.1 hypothetical protein -
DIE29_RS04580 942537..942800 - 264 WP_114649338.1 helix-turn-helix domain-containing protein -
DIE29_RS04585 943031..943486 + 456 WP_114649339.1 helix-turn-helix domain-containing protein Antitoxin
DIE29_RS04590 943491..944063 + 573 WP_114649340.1 PIN domain-containing protein Toxin
DIE29_RS04595 944083..946152 + 2070 WP_205409780.1 hypothetical protein -
DIE29_RS04600 946450..946641 + 192 WP_114649341.1 hypothetical protein -
DIE29_RS04605 946641..947093 + 453 WP_114649342.1 DUF2924 domain-containing protein -
DIE29_RS04610 947090..948478 + 1389 WP_205409781.1 recombinase family protein -
DIE29_RS04615 948475..948852 + 378 WP_205409807.1 site-specific recombinase resolvase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 938451..939263 812


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-114)

Antitoxin

SinI-like, DNA-binding domain

(81-126)


Sequences

Toxin        


Download         Length: 191 a.a.        Molecular weight: 21552.82 Da        Isoelectric Point: 6.6567

>T105462 WP_114649340.1 NZ_CP029331:943491-944063 [Thauera hydrothermalis]
MSSHFTVVYDACVFYPAPLRDLLMHLALSDLYRARWSDRIHAEWMRNVLASRPDLTQDQLNRTRRLMNAHVRDCLVTGFE
HLIPAIELPDPDDRHVVAAAIHAGASLIVTFNLKDFPVEALRPYNLAAQHPDDFIVDLLDLHPAGVLEAAARHRRSLKNP
PKTAEEYLDTLLAQGLTQSVAAMRQWIMAM

Download         Length: 573 bp

>T105462 NZ_CP029331:943491-944063 [Thauera hydrothermalis]
ATGAGTTCGCATTTCACCGTCGTCTATGACGCCTGCGTGTTCTATCCGGCACCCCTGCGTGACCTGTTGATGCATCTGGC
GCTGTCGGATCTGTACCGGGCGCGCTGGAGCGACCGGATTCACGCCGAGTGGATGCGCAACGTCCTGGCCAGCCGCCCCG
ATCTCACTCAAGACCAGCTGAACCGGACGCGCCGGCTGATGAACGCCCACGTCCGGGACTGCCTGGTCACCGGCTTCGAG
CACCTGATCCCCGCAATCGAACTGCCAGACCCCGACGACCGCCATGTGGTAGCAGCCGCCATCCACGCCGGTGCCAGTCT
GATCGTGACCTTCAACCTCAAGGACTTCCCGGTCGAGGCGCTGCGCCCCTACAACCTCGCCGCCCAGCATCCGGACGACT
TCATCGTCGATCTGCTCGATCTGCATCCAGCCGGCGTGCTGGAGGCCGCGGCCCGCCATCGCCGCTCCCTGAAAAACCCG
CCCAAGACGGCGGAGGAATACCTCGACACCCTGCTGGCGCAGGGGCTGACGCAATCGGTGGCGGCGATGCGCCAATGGAT
CATGGCCATGTGA

Antitoxin


Download         Length: 152 a.a.        Molecular weight: 16675.05 Da        Isoelectric Point: 6.4901

>AT105462 WP_114649339.1 NZ_CP029331:943031-943486 [Thauera hydrothermalis]
MTTTAKALPSAEDIALARESGRVLSTVLQTRADTQTIDFHDDKGTVRSVTLPTSALRLLLDVLTEIGQGNAVTIIPIHAE
LTTQEAADLLNVSRPFLVQLLEKGEIPFHKIGTHRRVRYQDVIAYKNRIDAERRKALDELAAQAQELGMGY

Download         Length: 456 bp

>AT105462 NZ_CP029331:943031-943486 [Thauera hydrothermalis]
ATGACCACCACCGCCAAGGCGCTGCCCTCCGCCGAGGACATCGCACTGGCCCGGGAGTCCGGGCGGGTGCTGTCGACCGT
GCTGCAGACCCGCGCGGACACCCAGACCATCGACTTCCACGACGACAAAGGCACCGTGCGATCGGTGACGCTGCCCACCT
CGGCGCTGCGCCTGCTGCTGGATGTGCTGACCGAGATCGGTCAGGGCAACGCCGTCACCATCATTCCCATCCACGCCGAG
CTGACGACGCAGGAGGCGGCCGATCTGCTCAACGTCTCGCGCCCCTTCCTCGTGCAGTTGCTGGAGAAAGGCGAGATCCC
GTTCCACAAGATCGGCACGCACCGCCGCGTGCGCTACCAGGACGTGATTGCCTACAAGAACCGCATCGACGCCGAGCGGC
GCAAGGCGCTCGACGAACTGGCGGCCCAGGCCCAGGAACTCGGCATGGGGTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References