Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4181852..4182636 Replicon chromosome
Accession NZ_CP029328
Organism Escherichia coli strain A1

Toxin (Protein)


Gene name yeeV Uniprot ID C7BUQ8
Locus tag AOY52_RS20350 Protein ID WP_000854717.1
Coordinates 4182310..4182636 (+) Length 109 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID C7BUQ9
Locus tag AOY52_RS20345 Protein ID WP_001285644.1
Coordinates 4181852..4182220 (+) Length 123 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AOY52_RS20305 (4177014) 4177014..4177795 + 782 Protein_3969 IS3 family transposase -
AOY52_RS20315 (4179103) 4179103..4179540 + 438 Protein_3971 integrase core domain-containing protein -
AOY52_RS20320 (4179550) 4179550..4180101 + 552 Protein_3972 DUF932 domain-containing protein -
AOY52_RS20325 (4180101) 4180101..4180346 + 246 WP_001164975.1 hypothetical protein -
AOY52_RS20330 (4180440) 4180440..4180913 + 474 WP_053879022.1 antirestriction protein -
AOY52_RS20335 (4180929) 4180929..4181405 + 477 WP_001368782.1 RadC family protein -
AOY52_RS20340 (4181468) 4181468..4181689 + 222 WP_000692319.1 DUF987 domain-containing protein -
AOY52_RS20345 (4181852) 4181852..4182220 + 369 WP_001285644.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
AOY52_RS20350 (4182310) 4182310..4182636 + 327 WP_000854717.1 TA system toxin CbtA family protein Toxin
AOY52_RS20355 (4182684) 4182684..4183172 + 489 WP_000761729.1 DUF5983 family protein -
AOY52_RS20360 (4183184) 4183184..4183381 + 198 WP_000839243.1 DUF957 domain-containing protein -
AOY52_RS20365 (4183466) 4183466..4184308 + 843 WP_001378387.1 DUF4942 domain-containing protein -
AOY52_RS20370 (4184651) 4184651..4185187 - 537 WP_000942795.1 GspM family type II secretion system protein YghD -
AOY52_RS20375 (4185189) 4185189..4186367 - 1179 WP_000094962.1 type II secretion system protein GspL -
AOY52_RS20380 (4186364) 4186364..4187341 - 978 WP_000633238.1 type II secretion system minor pseudopilin GspK -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-108)

Antitoxin

(18-117)


Sequences


Toxin        


Download         Length: 109 a.a.        Molecular weight: 12194.91 Da        Isoelectric Point: 6.4697

>T105458 WP_000854717.1 NZ_CP029328:4182310-4182636 [Escherichia coli]
MKTLPDTHVREASRCPSPVIIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQSGF
SACTHSQLINSIDILRARRATGLMTRDN

Download         Length: 327 bp

>T105458 NZ_CP029328:4182310-4182636 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCATCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGTCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGACTCGCGA
CAATTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13533.31 Da        Isoelectric Point: 5.0235

>AT105458 WP_001285644.1 NZ_CP029328:4181852-4182220 [Escherichia coli]
VSDTLSGTTHPDDNHDHPWWGLPCTVTPCFGVCLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELSPRYQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT105458 NZ_CP029328:4181852-4182220 [Escherichia coli]
GTGTCAGACACACTCTCCGGGACAACGCATCCCGATGACAATCACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGTCTGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGTGGT
GAACTCAGCCCCCGCTATCAGCATACCGTCACGCTGTATGCGAAAGGACTGACCTGCGAAGCCGATACCCTGGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB C7BUQ8


Antitoxin

Source ID Structure
AlphaFold DB C7BUQ9

References