Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 4131341..4132173 | Replicon | chromosome |
| Accession | NZ_CP029328 | ||
| Organism | Escherichia coli strain A1 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | S1PD64 |
| Locus tag | AOY52_RS20030 | Protein ID | WP_000854753.1 |
| Coordinates | 4131799..4132173 (+) | Length | 125 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A7U9QGA8 |
| Locus tag | AOY52_RS20025 | Protein ID | WP_001280948.1 |
| Coordinates | 4131341..4131709 (+) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| AOY52_RS19995 (4128177) | 4128177..4128632 | + | 456 | WP_000581504.1 | IrmA family protein | - |
| AOY52_RS20000 (4128711) | 4128711..4128944 | + | 234 | WP_001119729.1 | DUF905 family protein | - |
| AOY52_RS20005 (4129044) | 4129044..4129862 | + | 819 | WP_001234620.1 | DUF932 domain-containing protein | - |
| AOY52_RS20010 (4129917) | 4129917..4130402 | + | 486 | WP_000849569.1 | antirestriction protein | - |
| AOY52_RS20015 (4130418) | 4130418..4130894 | + | 477 | WP_001186726.1 | RadC family protein | - |
| AOY52_RS20020 (4130957) | 4130957..4131178 | + | 222 | WP_000692311.1 | DUF987 domain-containing protein | - |
| AOY52_RS20025 (4131341) | 4131341..4131709 | + | 369 | WP_001280948.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| AOY52_RS20030 (4131799) | 4131799..4132173 | + | 375 | WP_000854753.1 | TA system toxin CbtA family protein | Toxin |
| AOY52_RS20035 (4132170) | 4132170..4132658 | + | 489 | WP_000777552.1 | DUF5983 family protein | - |
| AOY52_RS20040 (4132670) | 4132670..4132867 | + | 198 | WP_000839281.1 | DUF957 domain-containing protein | - |
| AOY52_RS20045 (4132964) | 4132964..4133332 | + | 369 | Protein_3917 | DUF4942 domain-containing protein | - |
| AOY52_RS20050 (4133387) | 4133387..4134064 | + | 678 | WP_001299364.1 | IS66-like element accessory protein TnpA | - |
| AOY52_RS20055 (4134064) | 4134064..4134411 | + | 348 | WP_000624622.1 | IS66 family insertion sequence element accessory protein TnpB | - |
| AOY52_RS20060 (4134431) | 4134431..4136002 | + | 1572 | WP_074676071.1 | IS66 family transposase | - |
| AOY52_RS20065 (4136032) | 4136032..4136241 | + | 210 | Protein_3921 | DUF4942 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 14005.00 Da Isoelectric Point: 8.2905
>T105457 WP_000854753.1 NZ_CP029328:4131799-4132173 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR
Download Length: 375 bp
>T105457 NZ_CP029328:4131799-4132173 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGAAACGATGA
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGAAACGATGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13609.50 Da Isoelectric Point: 7.3991
>AT105457 WP_001280948.1 NZ_CP029328:4131341-4131709 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK
Download Length: 369 bp
>AT105457 NZ_CP029328:4131341-4131709 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCGAAAGGTCTGACCTGCAAAGCTGACACCCTCGGTAGCGG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCGAAAGGTCTGACCTGCAAAGCTGACACCCTCGGTAGCGG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U9LVU0 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U9QGA8 |