Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2503275..2503801 Replicon chromosome
Accession NZ_CP029328
Organism Escherichia coli strain A1

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag AOY52_RS12050 Protein ID WP_000323025.1
Coordinates 2503275..2503562 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag AOY52_RS12055 Protein ID WP_000534858.1
Coordinates 2503562..2503801 (-) Length 80 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AOY52_RS12000 (2498299) 2498299..2498514 - 216 WP_000839590.1 phage lysis protein EssD -
AOY52_RS12005 (2498734) 2498734..2498904 + 171 WP_211180497.1 putative zinc-binding protein YnfU -
AOY52_RS12010 (2499268) 2499268..2499483 - 216 WP_000066484.1 cold shock-like protein CspB -
AOY52_RS12015 (2499784) 2499784..2499996 + 213 WP_000087756.1 cold shock-like protein CspF -
AOY52_RS12020 (2500051) 2500051..2500140 + 90 WP_120795389.1 hypothetical protein -
AOY52_RS12025 (2500418) 2500418..2501170 - 753 WP_001047135.1 antitermination protein -
AOY52_RS12030 (2501184) 2501184..2502233 - 1050 WP_001265198.1 DUF968 domain-containing protein -
AOY52_RS12035 (2502235) 2502235..2502513 - 279 WP_012304870.1 hypothetical protein -
AOY52_RS12040 (2502580) 2502580..2502831 - 252 WP_000980994.1 protein Rem -
AOY52_RS12045 (2503048) 2503048..2503203 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
AOY52_RS12050 (2503275) 2503275..2503562 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
AOY52_RS12055 (2503562) 2503562..2503801 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
AOY52_RS12060 (2503826) 2503826..2504131 + 306 WP_001326990.1 protein YdfV -
AOY52_RS12065 (2504334) 2504334..2504666 + 333 WP_001301033.1 FlxA-like family protein -
AOY52_RS12070 (2505103) 2505103..2505252 - 150 WP_011443592.1 protein YdfW -
AOY52_RS12075 (2505325) 2505325..2506395 - 1071 Protein_2351 ISNCY family transposase -
AOY52_RS12080 (2506900) 2506900..2507922 - 1023 WP_000915483.1 DUF4868 domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2466104..2519030 52926


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T105444 WP_000323025.1 NZ_CP029328:c2503562-2503275 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T105444 NZ_CP029328:c2503562-2503275 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT105444 WP_000534858.1 NZ_CP029328:c2503801-2503562 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT105444 NZ_CP029328:c2503801-2503562 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9


Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References