Detailed information of TA system TA105433

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 4046977..4047805
• Replicon: chromosome
• Accession: NZ_CP029327
• Organism: Escherichia coli strain A37

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: AOY90_RS19525
• Protein ID: WP_089569554.1
• Coordinates: 4047431..4047805 (+)
• Length: 125 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: AOY90_RS19520
• Protein ID: WP_024230663.1
• Coordinates: 4046977..4047342 (+)
• Length: 122 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AOY90_RS19500 (4044732)	4044732..4045550	+	819	WP_097751937.1	DUF932 domain-containing protein	-
AOY90_RS19505 (4045642)	4045642..4046127	+	486	WP_097751936.1	antirestriction protein	-
AOY90_RS19510 (4046143)	4046143..4046619	+	477	WP_001351157.1	RadC family protein	-
AOY90_RS19515 (4046682)	4046682..4046903	+	222	WP_000692323.1	DUF987 domain-containing protein	-
AOY90_RS19520 (4046977)	4046977..4047342	+	366	WP_024230663.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
AOY90_RS19525 (4047431)	4047431..4047805	+	375	WP_089569554.1	type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA	Toxin
AOY90_RS19530 (4047805)	4047805..4048002	+	198	Protein_3806	DUF5983 family protein	-
AOY90_RS19535 (4048030)	4048030..4048227	+	198	WP_023563519.1	DUF957 domain-containing protein	-
AOY90_RS19540 (4048312)	4048312..4049154	+	843	WP_001280485.1	DUF4942 domain-containing protein	-
AOY90_RS19545 (4049434)	4049434..4049970	-	537	WP_000942816.1	GspM family type II secretion system protein YghD	-
AOY90_RS19550 (4049972)	4049972..4051150	-	1179	WP_240728654.1	type II secretion system protein GspL	-
AOY90_RS19555 (4051147)	4051147..4052124	-	978	WP_097751935.1	type II secretion system minor pseudopilin GspK	-
AOY90_RS19560 (4052121)	4052121..4052726	-	606	WP_001250457.1	type II secretion system minor pseudopilin GspJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (17-116)

Sequences

Toxin

Protein

• Length: 125 a.a.
• Molecular weight: 13800.77 Da
• Isoelectric Point: 6.4612

>T105433 WP_089569554.1 NZ_CP029327:4047431-4047805 [Escherichia coli]
MKTLPVLPGQAASSRLSPVEIWQILLSRLLDQHYGLTLDDTPFADERVIEQHIEAGISLCDAVNFLVEKYTLVRTDQPGF
SAGASSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Nucleotide

• Length: 375 bp

>T105433 NZ_CP029327:4047431-4047805 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCACGCCTGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
ACGGTTGCTGGACCAGCATTACGGCCTTACGCTGGATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCGGGTATTTCACTGTGCGATGCAGTGAACTTTCTCGTTGAAAAATACACACTGGTGCGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCTCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin

Protein

• Length: 122 a.a.
• Molecular weight: 13494.31 Da
• Isoelectric Point: 6.4648

>AT105433 WP_024230663.1 NZ_CP029327:4046977-4047342 [Escherichia coli]
VSDTLPGTTHPDNNNRPWWGLPCTVMPCFGARLVQEGNRLHYLADRAGIRGRFSDADSYHLDQAFPLLMKQLELMLTSGE
LSPRYQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKT

Nucleotide

• Length: 366 bp

>AT105433 NZ_CP029327:4046977-4047342 [Escherichia coli]
GTGTCAGACACACTGCCCGGGACAACGCATCCCGACAACAACAACCGCCCCTGGTGGGGGCTACCCTGCACCGTGATGCC
CTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGTTCA
GCGACGCGGATTCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGTGGTGAA
CTCAGCCCCCGCTATCAGCATACCGTCACGCTGTATGCGAAAGGACTGACCTGCGAAGCCGATACCCTAGGCTCCTGTGG
TTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAACGTAA