Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 39364..40031 Replicon plasmid unnamedc
Accession NZ_CP029286
Organism Xanthomonas phaseoli pv. phaseoli strain Xcp25

Toxin (Protein)


Gene name vapC Uniprot ID A0A3T0G501
Locus tag DGM81_RS22025 Protein ID WP_022557732.1
Coordinates 39615..40031 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U4M4Z6
Locus tag DGM81_RS22020 Protein ID WP_022557731.1
Coordinates 39364..39618 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DGM81_RS22010 (DGM81_23305) 35533..38562 - 3030 WP_022560486.1 Tn3 family transposase -
DGM81_RS22015 (DGM81_23310) 38559..39152 - 594 WP_022560487.1 recombinase family protein -
DGM81_RS22020 (DGM81_23315) 39364..39618 + 255 WP_022557731.1 plasmid stability protein Antitoxin
DGM81_RS22025 (DGM81_23320) 39615..40031 + 417 WP_022557732.1 type II toxin-antitoxin system VapC family toxin Toxin
DGM81_RS22030 (DGM81_23325) 40045..40593 + 549 WP_039588199.1 plasmid pRiA4b ORF-3 family protein -
DGM81_RS22035 (DGM81_23330) 40806..41078 + 273 WP_046121237.1 hypothetical protein -
DGM81_RS22040 (DGM81_23335) 41391..42032 + 642 WP_039575435.1 DNA-binding protein -
DGM81_RS22045 (DGM81_23340) 42045..42614 + 570 WP_022560534.1 restriction endonuclease -
DGM81_RS22050 (DGM81_23350) 42681..43768 - 1088 Protein_47 IS3 family transposase -
DGM81_RS22055 (DGM81_23355) 43959..44210 + 252 WP_039573365.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..48252 48252
- inside IScluster/Tn - - 27346..43768 16422


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-128)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14833.04 Da        Isoelectric Point: 4.6812

>T105397 WP_022557732.1 NZ_CP029286:39615-40031 [Xanthomonas phaseoli pv. phaseoli]
MIVLDTNVVSEAMKPEPHPSVRTWLNDQAAETLYLSSVTLAELLFGIAALPAGKRKDMLEQALDGLMGLFRDRVLPFDID
AARRYAELAVTAKIGGRGFPTPDGYIAAIAASRGFIVASRDTAPYEAAGVTVINPWEG

Download         Length: 417 bp

>T105397 NZ_CP029286:39615-40031 [Xanthomonas phaseoli pv. phaseoli]
ATGATCGTTCTCGATACCAACGTCGTTTCCGAGGCGATGAAGCCCGAGCCGCACCCATCCGTGCGGACCTGGTTGAACGA
TCAAGCCGCTGAAACACTGTACCTGTCCAGCGTGACGCTGGCCGAACTGCTATTTGGCATCGCTGCGCTTCCTGCCGGTA
AGCGCAAGGACATGCTGGAACAGGCCCTTGATGGCCTCATGGGCCTGTTTAGGGATCGGGTGTTGCCATTCGACATCGAT
GCAGCGCGGCGTTATGCCGAATTGGCCGTGACGGCAAAGATCGGAGGGCGAGGATTTCCGACACCCGACGGCTACATCGC
AGCGATTGCTGCCTCGCGGGGTTTCATTGTGGCGTCACGCGACACGGCCCCTTACGAAGCGGCCGGCGTAACCGTCATCA
ATCCGTGGGAAGGGTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9388.80 Da        Isoelectric Point: 8.9326

>AT105397 WP_022557731.1 NZ_CP029286:39364-39618 [Xanthomonas phaseoli pv. phaseoli]
MAMLTVRNLPDDVHRALRMRAAQNGHSTEAEVREILATAVKPETRVRLGEALAALGRKIGLTNEDFEVFDRVRDKTPAVP
PRLE

Download         Length: 255 bp

>AT105397 NZ_CP029286:39364-39618 [Xanthomonas phaseoli pv. phaseoli]
ATGGCAATGCTGACAGTACGTAATCTGCCGGATGATGTGCACCGCGCATTGCGCATGCGGGCCGCTCAAAATGGGCACAG
CACCGAGGCCGAGGTCCGCGAGATTCTGGCGACCGCAGTCAAGCCAGAGACGCGCGTTCGCCTAGGCGAAGCCTTGGCGG
CTTTGGGTCGCAAGATTGGCCTGACGAATGAGGACTTCGAGGTCTTCGATCGGGTAAGAGACAAGACGCCGGCCGTCCCG
CCGAGGCTTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T0G501

Antitoxin

Source ID Structure
AlphaFold DB A0A3T0G545

References