Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 23418..24085 Replicon plasmid unnameda
Accession NZ_CP029285
Organism Xanthomonas phaseoli pv. phaseoli strain Xcp25

Toxin (Protein)


Gene name vapC Uniprot ID A0A3T0G501
Locus tag DGM81_RS21635 Protein ID WP_022557732.1
Coordinates 23669..24085 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U4M4Z6
Locus tag DGM81_RS21630 Protein ID WP_022557731.1
Coordinates 23418..23672 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DGM81_RS21615 19169..19554 - 386 Protein_27 IS3 family transposase -
DGM81_RS21620 (DGM81_22860) 19587..22616 - 3030 WP_022560486.1 Tn3 family transposase -
DGM81_RS21625 (DGM81_22865) 22613..23206 - 594 WP_022560487.1 recombinase family protein -
DGM81_RS21630 (DGM81_22870) 23418..23672 + 255 WP_022557731.1 plasmid stability protein Antitoxin
DGM81_RS21635 (DGM81_22875) 23669..24085 + 417 WP_022557732.1 type II toxin-antitoxin system VapC family toxin Toxin
DGM81_RS21640 (DGM81_22880) 24099..24647 + 549 WP_039588199.1 plasmid pRiA4b ORF-3 family protein -
DGM81_RS21645 (DGM81_22885) 24676..24813 - 138 Protein_33 transposase -
DGM81_RS21650 (DGM81_22890) 24862..25410 - 549 WP_022557734.1 DNA topoisomerase -
DGM81_RS21655 (DGM81_22895) 25565..26857 - 1293 WP_033481893.1 M12 family metallo-peptidase -
DGM81_RS21660 (DGM81_22900) 26984..28303 - 1320 WP_022557736.1 right-handed parallel beta-helix repeat-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - virB1 1..57691 57691
- inside IScluster/Tn - virB1 7288..24813 17525


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-128)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14833.04 Da        Isoelectric Point: 4.6812

>T105396 WP_022557732.1 NZ_CP029285:23669-24085 [Xanthomonas phaseoli pv. phaseoli]
MIVLDTNVVSEAMKPEPHPSVRTWLNDQAAETLYLSSVTLAELLFGIAALPAGKRKDMLEQALDGLMGLFRDRVLPFDID
AARRYAELAVTAKIGGRGFPTPDGYIAAIAASRGFIVASRDTAPYEAAGVTVINPWEG

Download         Length: 417 bp

>T105396 NZ_CP029285:23669-24085 [Xanthomonas phaseoli pv. phaseoli]
ATGATCGTTCTCGATACCAACGTCGTTTCCGAGGCGATGAAGCCCGAGCCGCACCCATCCGTGCGGACCTGGTTGAACGA
TCAAGCCGCTGAAACACTGTACCTGTCCAGCGTGACGCTGGCCGAACTGCTATTTGGCATCGCTGCGCTTCCTGCCGGTA
AGCGCAAGGACATGCTGGAACAGGCCCTTGATGGCCTCATGGGCCTGTTTAGGGATCGGGTGTTGCCATTCGACATCGAT
GCAGCGCGGCGTTATGCCGAATTGGCCGTGACGGCAAAGATCGGAGGGCGAGGATTTCCGACACCCGACGGCTACATCGC
AGCGATTGCTGCCTCGCGGGGTTTCATTGTGGCGTCACGCGACACGGCCCCTTACGAAGCGGCCGGCGTAACCGTCATCA
ATCCGTGGGAAGGGTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9388.80 Da        Isoelectric Point: 8.9326

>AT105396 WP_022557731.1 NZ_CP029285:23418-23672 [Xanthomonas phaseoli pv. phaseoli]
MAMLTVRNLPDDVHRALRMRAAQNGHSTEAEVREILATAVKPETRVRLGEALAALGRKIGLTNEDFEVFDRVRDKTPAVP
PRLE

Download         Length: 255 bp

>AT105396 NZ_CP029285:23418-23672 [Xanthomonas phaseoli pv. phaseoli]
ATGGCAATGCTGACAGTACGTAATCTGCCGGATGATGTGCACCGCGCATTGCGCATGCGGGCCGCTCAAAATGGGCACAG
CACCGAGGCCGAGGTCCGCGAGATTCTGGCGACCGCAGTCAAGCCAGAGACGCGCGTTCGCCTAGGCGAAGCCTTGGCGG
CTTTGGGTCGCAAGATTGGCCTGACGAATGAGGACTTCGAGGTCTTCGATCGGGTAAGAGACAAGACGCCGGCCGTCCCG
CCGAGGCTTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T0G501

Antitoxin

Source ID Structure
AlphaFold DB A0A3T0G545

References