Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 23428..24095 Replicon plasmid unnameda
Accession NZ_CP029282
Organism Xanthomonas phaseoli pv. phaseoli strain Px100

Toxin (Protein)


Gene name vapC Uniprot ID A0A3T0G501
Locus tag DGM85_RS22040 Protein ID WP_022557732.1
Coordinates 23679..24095 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U4M4Z6
Locus tag DGM85_RS22035 Protein ID WP_022557731.1
Coordinates 23428..23682 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DGM85_RS22020 19179..19564 - 386 Protein_27 IS3 family transposase -
DGM85_RS22025 (DGM85_23160) 19597..22626 - 3030 WP_022560486.1 Tn3 family transposase -
DGM85_RS22030 (DGM85_23165) 22623..23216 - 594 WP_022560487.1 recombinase family protein -
DGM85_RS22035 (DGM85_23170) 23428..23682 + 255 WP_022557731.1 plasmid stability protein Antitoxin
DGM85_RS22040 (DGM85_23175) 23679..24095 + 417 WP_022557732.1 type II toxin-antitoxin system VapC family toxin Toxin
DGM85_RS22045 (DGM85_23180) 24109..24663 + 555 WP_033482006.1 plasmid pRiA4b ORF-3 family protein -
DGM85_RS22050 (DGM85_23185) 24738..24875 - 138 Protein_33 transposase -
DGM85_RS22055 (DGM85_23190) 24924..25472 - 549 WP_022557734.1 DNA topoisomerase -
DGM85_RS22060 (DGM85_23195) 25627..26919 - 1293 WP_033481893.1 M12 family metallo-peptidase -
DGM85_RS22065 (DGM85_23200) 27046..28365 - 1320 WP_022557736.1 right-handed parallel beta-helix repeat-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - virB1 1..57773 57773
- inside IScluster/Tn - virB1 7298..24875 17577


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-128)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14833.04 Da        Isoelectric Point: 4.6812

>T105392 WP_022557732.1 NZ_CP029282:23679-24095 [Xanthomonas phaseoli pv. phaseoli]
MIVLDTNVVSEAMKPEPHPSVRTWLNDQAAETLYLSSVTLAELLFGIAALPAGKRKDMLEQALDGLMGLFRDRVLPFDID
AARRYAELAVTAKIGGRGFPTPDGYIAAIAASRGFIVASRDTAPYEAAGVTVINPWEG

Download         Length: 417 bp

>T105392 NZ_CP029282:23679-24095 [Xanthomonas phaseoli pv. phaseoli]
ATGATCGTTCTCGATACCAACGTCGTTTCCGAGGCGATGAAGCCCGAGCCGCACCCATCCGTGCGGACCTGGTTGAACGA
TCAAGCCGCTGAAACACTGTACCTGTCCAGCGTGACGCTGGCCGAACTGCTATTTGGCATCGCTGCGCTTCCTGCCGGTA
AGCGCAAGGACATGCTGGAACAGGCCCTTGATGGCCTCATGGGCCTGTTTAGGGATCGGGTGTTGCCATTCGACATCGAT
GCAGCGCGGCGTTATGCCGAATTGGCCGTGACGGCAAAGATCGGAGGGCGAGGATTTCCGACACCCGACGGCTACATCGC
AGCGATTGCTGCCTCGCGGGGTTTCATTGTGGCGTCACGCGACACGGCCCCTTACGAAGCGGCCGGCGTAACCGTCATCA
ATCCGTGGGAAGGGTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9388.80 Da        Isoelectric Point: 8.9326

>AT105392 WP_022557731.1 NZ_CP029282:23428-23682 [Xanthomonas phaseoli pv. phaseoli]
MAMLTVRNLPDDVHRALRMRAAQNGHSTEAEVREILATAVKPETRVRLGEALAALGRKIGLTNEDFEVFDRVRDKTPAVP
PRLE

Download         Length: 255 bp

>AT105392 NZ_CP029282:23428-23682 [Xanthomonas phaseoli pv. phaseoli]
ATGGCAATGCTGACAGTACGTAATCTGCCGGATGATGTGCACCGCGCATTGCGCATGCGGGCCGCTCAAAATGGGCACAG
CACCGAGGCCGAGGTCCGCGAGATTCTGGCGACCGCAGTCAAGCCAGAGACGCGCGTTCGCCTAGGCGAAGCCTTGGCGG
CTTTGGGTCGCAAGATTGGCCTGACGAATGAGGACTTCGAGGTCTTCGATCGGGTAAGAGACAAGACGCCGGCCGTCCCG
CCGAGGCTTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T0G501

Antitoxin

Source ID Structure
AlphaFold DB A0A3T0G545

References