Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 40701..41368 Replicon plasmid unnamedc
Accession NZ_CP029279
Organism Xanthomonas phaseoli pv. phaseoli strain PR1

Toxin (Protein)


Gene name vapC Uniprot ID A0A3T0G501
Locus tag DGM93_RS22345 Protein ID WP_022557732.1
Coordinates 40952..41368 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U4M4Z6
Locus tag DGM93_RS22340 Protein ID WP_022557731.1
Coordinates 40701..40955 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DGM93_RS22330 (DGM93_23565) 36870..39899 - 3030 WP_022560486.1 Tn3 family transposase -
DGM93_RS22335 (DGM93_23570) 39896..40489 - 594 WP_022560487.1 recombinase family protein -
DGM93_RS22340 (DGM93_23575) 40701..40955 + 255 WP_022557731.1 plasmid stability protein Antitoxin
DGM93_RS22345 (DGM93_23580) 40952..41368 + 417 WP_022557732.1 type II toxin-antitoxin system VapC family toxin Toxin
DGM93_RS22350 (DGM93_23585) 41382..41930 + 549 WP_039588199.1 plasmid pRiA4b ORF-3 family protein -
DGM93_RS22355 (DGM93_23590) 42143..42415 + 273 WP_046121237.1 hypothetical protein -
DGM93_RS22360 (DGM93_23595) 42728..43369 + 642 WP_039575435.1 DNA-binding protein -
DGM93_RS22365 (DGM93_23600) 43382..43951 + 570 WP_022560534.1 restriction endonuclease -
DGM93_RS22370 (DGM93_23610) 44018..45105 - 1088 Protein_49 IS3 family transposase -
DGM93_RS22375 (DGM93_23615) 45296..45547 + 252 WP_039573365.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..49589 49589
- inside IScluster/Tn - - 28683..45105 16422


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-128)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14833.04 Da        Isoelectric Point: 4.6812

>T105389 WP_022557732.1 NZ_CP029279:40952-41368 [Xanthomonas phaseoli pv. phaseoli]
MIVLDTNVVSEAMKPEPHPSVRTWLNDQAAETLYLSSVTLAELLFGIAALPAGKRKDMLEQALDGLMGLFRDRVLPFDID
AARRYAELAVTAKIGGRGFPTPDGYIAAIAASRGFIVASRDTAPYEAAGVTVINPWEG

Download         Length: 417 bp

>T105389 NZ_CP029279:40952-41368 [Xanthomonas phaseoli pv. phaseoli]
ATGATCGTTCTCGATACCAACGTCGTTTCCGAGGCGATGAAGCCCGAGCCGCACCCATCCGTGCGGACCTGGTTGAACGA
TCAAGCCGCTGAAACACTGTACCTGTCCAGCGTGACGCTGGCCGAACTGCTATTTGGCATCGCTGCGCTTCCTGCCGGTA
AGCGCAAGGACATGCTGGAACAGGCCCTTGATGGCCTCATGGGCCTGTTTAGGGATCGGGTGTTGCCATTCGACATCGAT
GCAGCGCGGCGTTATGCCGAATTGGCCGTGACGGCAAAGATCGGAGGGCGAGGATTTCCGACACCCGACGGCTACATCGC
AGCGATTGCTGCCTCGCGGGGTTTCATTGTGGCGTCACGCGACACGGCCCCTTACGAAGCGGCCGGCGTAACCGTCATCA
ATCCGTGGGAAGGGTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9388.80 Da        Isoelectric Point: 8.9326

>AT105389 WP_022557731.1 NZ_CP029279:40701-40955 [Xanthomonas phaseoli pv. phaseoli]
MAMLTVRNLPDDVHRALRMRAAQNGHSTEAEVREILATAVKPETRVRLGEALAALGRKIGLTNEDFEVFDRVRDKTPAVP
PRLE

Download         Length: 255 bp

>AT105389 NZ_CP029279:40701-40955 [Xanthomonas phaseoli pv. phaseoli]
ATGGCAATGCTGACAGTACGTAATCTGCCGGATGATGTGCACCGCGCATTGCGCATGCGGGCCGCTCAAAATGGGCACAG
CACCGAGGCCGAGGTCCGCGAGATTCTGGCGACCGCAGTCAAGCCAGAGACGCGCGTTCGCCTAGGCGAAGCCTTGGCGG
CTTTGGGTCGCAAGATTGGCCTGACGAATGAGGACTTCGAGGTCTTCGATCGGGTAAGAGACAAGACGCCGGCCGTCCCG
CCGAGGCTTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T0G501

Antitoxin

Source ID Structure
AlphaFold DB A0A3T0G545

References