Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 16698..17365 Replicon plasmid unnameda
Accession NZ_CP029276
Organism Xanthomonas citri strain M11

Toxin (Protein)


Gene name vapC Uniprot ID A0A3T0G501
Locus tag DGM98_RS21945 Protein ID WP_022557732.1
Coordinates 16949..17365 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U4M4Z6
Locus tag DGM98_RS21940 Protein ID WP_022557731.1
Coordinates 16698..16952 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DGM98_RS21925 (DGM98_23020) 11876..12834 - 959 Protein_13 IS3-like element ISXcd1 family transposase -
DGM98_RS21930 (DGM98_23025) 12867..15896 - 3030 WP_022560486.1 Tn3 family transposase -
DGM98_RS21935 (DGM98_23030) 15893..16486 - 594 WP_022560487.1 recombinase family protein -
DGM98_RS21940 (DGM98_23035) 16698..16952 + 255 WP_022557731.1 plasmid stability protein Antitoxin
DGM98_RS21945 (DGM98_23040) 16949..17365 + 417 WP_022557732.1 type II toxin-antitoxin system VapC family toxin Toxin
DGM98_RS21950 (DGM98_23045) 17379..17933 + 555 WP_033482006.1 plasmid pRiA4b ORF-3 family protein -
DGM98_RS21955 (DGM98_23050) 18008..18145 - 138 Protein_19 transposase -
DGM98_RS21960 (DGM98_23055) 18194..18742 - 549 WP_022557734.1 DNA topoisomerase -
DGM98_RS21965 (DGM98_23060) 18897..20189 - 1293 WP_033481893.1 M12 family metallo-peptidase -
DGM98_RS21970 (DGM98_23065) 20316..21635 - 1320 WP_022557736.1 right-handed parallel beta-helix repeat-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..57069 57069
- inside IScluster/Tn - - 11876..18145 6269


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-128)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14833.04 Da        Isoelectric Point: 4.6812

>T105385 WP_022557732.1 NZ_CP029276:16949-17365 [Xanthomonas citri]
MIVLDTNVVSEAMKPEPHPSVRTWLNDQAAETLYLSSVTLAELLFGIAALPAGKRKDMLEQALDGLMGLFRDRVLPFDID
AARRYAELAVTAKIGGRGFPTPDGYIAAIAASRGFIVASRDTAPYEAAGVTVINPWEG

Download         Length: 417 bp

>T105385 NZ_CP029276:16949-17365 [Xanthomonas citri]
ATGATCGTTCTCGATACCAACGTCGTTTCCGAGGCGATGAAGCCCGAGCCGCACCCATCCGTGCGGACCTGGTTGAACGA
TCAAGCCGCTGAAACACTGTACCTGTCCAGCGTGACGCTGGCCGAACTGCTATTTGGCATCGCTGCGCTTCCTGCCGGTA
AGCGCAAGGACATGCTGGAACAGGCCCTTGATGGCCTCATGGGCCTGTTTAGGGATCGGGTGTTGCCATTCGACATCGAT
GCAGCGCGGCGTTATGCCGAATTGGCCGTGACGGCAAAGATCGGAGGGCGAGGATTTCCGACACCCGACGGCTACATCGC
AGCGATTGCTGCCTCGCGGGGTTTCATTGTGGCGTCACGCGACACGGCCCCTTACGAAGCGGCCGGCGTAACCGTCATCA
ATCCGTGGGAAGGGTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9388.80 Da        Isoelectric Point: 8.9326

>AT105385 WP_022557731.1 NZ_CP029276:16698-16952 [Xanthomonas citri]
MAMLTVRNLPDDVHRALRMRAAQNGHSTEAEVREILATAVKPETRVRLGEALAALGRKIGLTNEDFEVFDRVRDKTPAVP
PRLE

Download         Length: 255 bp

>AT105385 NZ_CP029276:16698-16952 [Xanthomonas citri]
ATGGCAATGCTGACAGTACGTAATCTGCCGGATGATGTGCACCGCGCATTGCGCATGCGGGCCGCTCAAAATGGGCACAG
CACCGAGGCCGAGGTCCGCGAGATTCTGGCGACCGCAGTCAAGCCAGAGACGCGCGTTCGCCTAGGCGAAGCCTTGGCGG
CTTTGGGTCGCAAGATTGGCCTGACGAATGAGGACTTCGAGGTCTTCGATCGGGTAAGAGACAAGACGCCGGCCGTCCCG
CCGAGGCTTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T0G501

Antitoxin

Source ID Structure
AlphaFold DB A0A3T0G545

References