Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 16699..17366 Replicon plasmid unnameda
Accession NZ_CP029274
Organism Xanthomonas citri strain T21

Toxin (Protein)


Gene name vapC Uniprot ID A0A3T0G501
Locus tag DGN02_RS22265 Protein ID WP_022557732.1
Coordinates 16950..17366 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U4M4Z6
Locus tag DGN02_RS22260 Protein ID WP_022557731.1
Coordinates 16699..16953 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DGN02_RS22245 (DGN02_23215) 11877..12835 - 959 Protein_13 IS3-like element ISXcd1 family transposase -
DGN02_RS22250 (DGN02_23220) 12868..15897 - 3030 WP_022560486.1 Tn3 family transposase -
DGN02_RS22255 (DGN02_23225) 15894..16487 - 594 WP_022560487.1 recombinase family protein -
DGN02_RS22260 (DGN02_23230) 16699..16953 + 255 WP_022557731.1 plasmid stability protein Antitoxin
DGN02_RS22265 (DGN02_23235) 16950..17366 + 417 WP_022557732.1 type II toxin-antitoxin system VapC family toxin Toxin
DGN02_RS22270 (DGN02_23240) 17380..17934 + 555 WP_033482006.1 plasmid pRiA4b ORF-3 family protein -
DGN02_RS22275 (DGN02_23245) 18009..18146 - 138 Protein_19 transposase -
DGN02_RS22280 (DGN02_23250) 18195..18743 - 549 WP_022557734.1 DNA topoisomerase -
DGN02_RS22285 (DGN02_23255) 18898..20190 - 1293 WP_033481893.1 M12 family metallo-peptidase -
DGN02_RS22290 (DGN02_23260) 20317..21636 - 1320 WP_022557736.1 right-handed parallel beta-helix repeat-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..57070 57070
- inside IScluster/Tn - - 11877..18146 6269


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-128)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14833.04 Da        Isoelectric Point: 4.6812

>T105381 WP_022557732.1 NZ_CP029274:16950-17366 [Xanthomonas citri]
MIVLDTNVVSEAMKPEPHPSVRTWLNDQAAETLYLSSVTLAELLFGIAALPAGKRKDMLEQALDGLMGLFRDRVLPFDID
AARRYAELAVTAKIGGRGFPTPDGYIAAIAASRGFIVASRDTAPYEAAGVTVINPWEG

Download         Length: 417 bp

>T105381 NZ_CP029274:16950-17366 [Xanthomonas citri]
ATGATCGTTCTCGATACCAACGTCGTTTCCGAGGCGATGAAGCCCGAGCCGCACCCATCCGTGCGGACCTGGTTGAACGA
TCAAGCCGCTGAAACACTGTACCTGTCCAGCGTGACGCTGGCCGAACTGCTATTTGGCATCGCTGCGCTTCCTGCCGGTA
AGCGCAAGGACATGCTGGAACAGGCCCTTGATGGCCTCATGGGCCTGTTTAGGGATCGGGTGTTGCCATTCGACATCGAT
GCAGCGCGGCGTTATGCCGAATTGGCCGTGACGGCAAAGATCGGAGGGCGAGGATTTCCGACACCCGACGGCTACATCGC
AGCGATTGCTGCCTCGCGGGGTTTCATTGTGGCGTCACGCGACACGGCCCCTTACGAAGCGGCCGGCGTAACCGTCATCA
ATCCGTGGGAAGGGTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9388.80 Da        Isoelectric Point: 8.9326

>AT105381 WP_022557731.1 NZ_CP029274:16699-16953 [Xanthomonas citri]
MAMLTVRNLPDDVHRALRMRAAQNGHSTEAEVREILATAVKPETRVRLGEALAALGRKIGLTNEDFEVFDRVRDKTPAVP
PRLE

Download         Length: 255 bp

>AT105381 NZ_CP029274:16699-16953 [Xanthomonas citri]
ATGGCAATGCTGACAGTACGTAATCTGCCGGATGATGTGCACCGCGCATTGCGCATGCGGGCCGCTCAAAATGGGCACAG
CACCGAGGCCGAGGTCCGCGAGATTCTGGCGACCGCAGTCAAGCCAGAGACGCGCGTTCGCCTAGGCGAAGCCTTGGCGG
CTTTGGGTCGCAAGATTGGCCTGACGAATGAGGACTTCGAGGTCTTCGATCGGGTAAGAGACAAGACGCCGGCCGTCCCG
CCGAGGCTTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T0G501

Antitoxin

Source ID Structure
AlphaFold DB A0A3T0G545

References