Detailed information of TA system TA105379

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/Phd(antitoxin)
• Location: 65257..65801
• Replicon: chromosome
• Accession: NZ_CP029273
• Organism: Xanthomonas citri strain T21

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: DGN02_RS00280
• Protein ID: WP_005912562.1
• Coordinates: 65523..65801 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A7Z7EKF2
• Locus tag: DGN02_RS00275
• Protein ID: WP_029818122.1
• Coordinates: 65257..65514 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DGN02_RS00260 (DGN02_00285)	60370..61857	-	1488	WP_099803355.1	ribonuclease H-like domain-containing protein	-
DGN02_RS00265 (DGN02_00290)	61854..64349	-	2496	WP_165785620.1	DEAD/DEAH box helicase	-
DGN02_RS00270 (DGN02_00295)	64528..65190	+	663	WP_029818121.1	hemolysin III family protein	-
DGN02_RS00275 (DGN02_00300)	65257..65514	+	258	WP_029818122.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
DGN02_RS00280 (DGN02_00305)	65523..65801	+	279	WP_005912562.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DGN02_RS00290 (DGN02_00315)	65981..66880	-	900	WP_099803356.1	SDR family NAD(P)-dependent oxidoreductase	-
DGN02_RS00295 (DGN02_00320)	66940..67677	-	738	WP_007964860.1	SDR family oxidoreductase	-
DGN02_RS00300 (DGN02_00325)	67803..68714	+	912	WP_099803357.1	LysR family transcriptional regulator	-
DGN02_RS00305 (DGN02_00330)	68915..69625	+	711	WP_099803358.1	hypothetical protein	-
DGN02_RS00310 (DGN02_00335)	69862..70470	-	609	WP_099803359.1	NAD(P)H-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10415.00 Da
• Isoelectric Point: 10.1557

>T105379 WP_005912562.1 NZ_CP029273:65523-65801 [Xanthomonas citri]
VPALADLDAIADYIAIDNAPAAAALVKRVFAHVEQLIEHPDSGSRPQELKRSRYRQIVEPPCRVFYRVDGQRIVVVHVMR
SERALRGNRLSR

Nucleotide

• Length: 279 bp

>T105379 NZ_CP029273:65523-65801 [Xanthomonas citri]
GTGCCGGCATTGGCTGATCTGGACGCAATCGCCGACTACATCGCAATCGATAACGCACCCGCTGCAGCGGCGCTGGTGAA
ACGGGTGTTCGCGCACGTTGAGCAATTGATTGAACACCCGGACAGCGGAAGCCGGCCACAGGAACTCAAGCGCTCGCGCT
ATCGCCAGATTGTCGAACCACCTTGCCGCGTGTTCTACCGCGTGGATGGGCAGCGCATCGTGGTGGTGCACGTAATGCGG
TCGGAGCGCGCGCTTCGCGGGAACCGTCTTTCACGCTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9632.12 Da
• Isoelectric Point: 8.6223

>AT105379 WP_029818122.1 NZ_CP029273:65257-65514 [Xanthomonas citri]
MRTELVTTLKRQATELLAAAERDKEPILITQHGLPSAYLVDVASYERMQQRIALLEGIARGEMAVADGRTLSHEQAQQRM
ARWLK

Nucleotide

• Length: 258 bp

>AT105379 NZ_CP029273:65257-65514 [Xanthomonas citri]
ATGCGCACCGAACTTGTCACCACGCTCAAGCGTCAGGCGACCGAACTCCTTGCAGCTGCAGAGCGCGACAAGGAGCCAAT
CCTGATCACACAGCACGGTTTACCCAGTGCCTATCTGGTGGATGTTGCCAGCTATGAGCGCATGCAGCAGCGCATTGCGC
TCCTCGAAGGAATCGCCCGGGGAGAAATGGCAGTCGCGGACGGCCGTACGCTGAGCCATGAACAGGCACAGCAACGCATG
GCGCGATGGCTGAAATAA

Structures

Antitoxin

• AlphaFold DB: A0A7Z7EKF2