Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 17974..18641 Replicon plasmid unnameda
Accession NZ_CP029272
Organism Xanthomonas citri pv. fuscans strain FH61

Toxin (Protein)


Gene name vapC Uniprot ID A0A3T0G501
Locus tag DGN07_RS22670 Protein ID WP_022557732.1
Coordinates 18225..18641 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U4M4Z6
Locus tag DGN07_RS22665 Protein ID WP_022557731.1
Coordinates 17974..18228 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DGN07_RS22645 13009..13155 + 147 WP_158526406.1 hypothetical protein -
DGN07_RS22650 (DGN07_23625) 13152..14110 - 959 Protein_15 IS3-like element ISXcd1 family transposase -
DGN07_RS22655 (DGN07_23630) 14143..17172 - 3030 WP_022560486.1 Tn3 family transposase -
DGN07_RS22660 (DGN07_23635) 17169..17762 - 594 WP_022560487.1 recombinase family protein -
DGN07_RS22665 (DGN07_23640) 17974..18228 + 255 WP_022557731.1 plasmid stability protein Antitoxin
DGN07_RS22670 (DGN07_23645) 18225..18641 + 417 WP_022557732.1 type II toxin-antitoxin system VapC family toxin Toxin
DGN07_RS22675 (DGN07_23650) 18655..19209 + 555 WP_033482006.1 plasmid pRiA4b ORF-3 family protein -
DGN07_RS22680 (DGN07_23655) 19284..19421 - 138 Protein_21 transposase -
DGN07_RS22685 (DGN07_23660) 19470..20018 - 549 WP_022557734.1 DNA topoisomerase -
DGN07_RS22690 (DGN07_23665) 20173..21465 - 1293 WP_033481893.1 M12 family metallo-peptidase -
DGN07_RS22695 (DGN07_23670) 21592..22911 - 1320 WP_022557736.1 right-handed parallel beta-helix repeat-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..49010 49010
- inside IScluster/Tn - - 8865..19421 10556


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-128)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14833.04 Da        Isoelectric Point: 4.6812

>T105378 WP_022557732.1 NZ_CP029272:18225-18641 [Xanthomonas citri pv. fuscans]
MIVLDTNVVSEAMKPEPHPSVRTWLNDQAAETLYLSSVTLAELLFGIAALPAGKRKDMLEQALDGLMGLFRDRVLPFDID
AARRYAELAVTAKIGGRGFPTPDGYIAAIAASRGFIVASRDTAPYEAAGVTVINPWEG

Download         Length: 417 bp

>T105378 NZ_CP029272:18225-18641 [Xanthomonas citri pv. fuscans]
ATGATCGTTCTCGATACCAACGTCGTTTCCGAGGCGATGAAGCCCGAGCCGCACCCATCCGTGCGGACCTGGTTGAACGA
TCAAGCCGCTGAAACACTGTACCTGTCCAGCGTGACGCTGGCCGAACTGCTATTTGGCATCGCTGCGCTTCCTGCCGGTA
AGCGCAAGGACATGCTGGAACAGGCCCTTGATGGCCTCATGGGCCTGTTTAGGGATCGGGTGTTGCCATTCGACATCGAT
GCAGCGCGGCGTTATGCCGAATTGGCCGTGACGGCAAAGATCGGAGGGCGAGGATTTCCGACACCCGACGGCTACATCGC
AGCGATTGCTGCCTCGCGGGGTTTCATTGTGGCGTCACGCGACACGGCCCCTTACGAAGCGGCCGGCGTAACCGTCATCA
ATCCGTGGGAAGGGTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9388.80 Da        Isoelectric Point: 8.9326

>AT105378 WP_022557731.1 NZ_CP029272:17974-18228 [Xanthomonas citri pv. fuscans]
MAMLTVRNLPDDVHRALRMRAAQNGHSTEAEVREILATAVKPETRVRLGEALAALGRKIGLTNEDFEVFDRVRDKTPAVP
PRLE

Download         Length: 255 bp

>AT105378 NZ_CP029272:17974-18228 [Xanthomonas citri pv. fuscans]
ATGGCAATGCTGACAGTACGTAATCTGCCGGATGATGTGCACCGCGCATTGCGCATGCGGGCCGCTCAAAATGGGCACAG
CACCGAGGCCGAGGTCCGCGAGATTCTGGCGACCGCAGTCAAGCCAGAGACGCGCGTTCGCCTAGGCGAAGCCTTGGCGG
CTTTGGGTCGCAAGATTGGCCTGACGAATGAGGACTTCGAGGTCTTCGATCGGGTAAGAGACAAGACGCCGGCCGTCCCG
CCGAGGCTTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T0G501

Antitoxin

Source ID Structure
AlphaFold DB A0A3T0G545

References