Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Phd(antitoxin)
Location 66004..66548 Replicon chromosome
Accession NZ_CP029267
Organism Xanthomonas citri pv. fuscans strain M12

Toxin (Protein)


Gene name relE Uniprot ID A0A808FED4
Locus tag DGN11_RS00275 Protein ID WP_022557812.1
Coordinates 66249..66548 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A828YMS8
Locus tag DGN11_RS00270 Protein ID WP_005912560.1
Coordinates 66004..66261 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DGN11_RS00255 (DGN11_00280) 61125..62606 - 1482 WP_046833465.1 ribonuclease H-like domain-containing protein -
DGN11_RS00260 (DGN11_00285) 62603..65098 - 2496 WP_022557810.1 DEAD/DEAH box helicase -
DGN11_RS00265 (DGN11_00290) 65276..65938 + 663 WP_029818121.1 hemolysin III family protein -
DGN11_RS00270 (DGN11_00295) 66004..66261 + 258 WP_005912560.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
DGN11_RS00275 (DGN11_00300) 66249..66548 + 300 WP_022557812.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DGN11_RS00285 (DGN11_00310) 66728..67627 - 900 WP_022557813.1 SDR family NAD(P)-dependent oxidoreductase -
DGN11_RS00290 (DGN11_00315) 67687..68424 - 738 WP_022557814.1 SDR family oxidoreductase -
DGN11_RS00295 (DGN11_00320) 68550..69461 + 912 WP_039732218.1 LysR family transcriptional regulator -
DGN11_RS00300 (DGN11_00330) 69676..70740 - 1065 WP_033481295.1 ATP-grasp fold amidoligase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11279.07 Da        Isoelectric Point: 10.1539

>T105371 WP_022557812.1 NZ_CP029267:66249-66548 [Xanthomonas citri pv. fuscans]
MAEIIWSVPALADLDAIADYIAIDNAPAAAALVKRVFAHVEQLIERPDSGSRPQELKRSRYRQIVEPPCRVFYRVDGQRI
VLVHVMRSERALRGNRLSR

Download         Length: 300 bp

>T105371 NZ_CP029267:66249-66548 [Xanthomonas citri pv. fuscans]
ATGGCTGAAATAATCTGGTCGGTGCCGGCATTGGCTGATCTGGACGCAATCGCCGACTACATCGCAATCGATAACGCACC
CGCTGCAGCGGCGCTGGTGAAACGGGTGTTCGCGCACGTTGAGCAATTGATCGAACGCCCGGACAGCGGAAGCCGGCCAC
AGGAACTCAAGCGCTCGCGCTATCGCCAGATTGTCGAACCACCTTGCCGCGTGTTCTACCGCGTGGATGGGCAGCGCATC
GTGCTGGTGCACGTAATGCGGTCGGAGCGCGCGCTTCGCGGGAACCGTCTTTCACGCTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9646.15 Da        Isoelectric Point: 8.6223

>AT105371 WP_005912560.1 NZ_CP029267:66004-66261 [Xanthomonas citri pv. fuscans]
MRTELVTTLKRQATELLAAAERDKEPILITQHGLPSAYLVDVASYERMQQRIALLEGIARGEMAVAEGRTLSHEQAQQRM
ARWLK

Download         Length: 258 bp

>AT105371 NZ_CP029267:66004-66261 [Xanthomonas citri pv. fuscans]
ATGCGCACCGAACTTGTCACCACGCTCAAGCGTCAGGCGACCGAACTCCTTGCAGCTGCAGAGCGCGACAAGGAGCCAAT
CCTGATCACACAGCACGGTTTACCCAGTGCCTATCTGGTGGATGTTGCCAGCTATGAGCGCATGCAGCAGCGCATTGCGC
TCCTCGAAGGAATCGCCCGGGGAGAAATGGCAGTCGCGGAAGGCCGTACGCTGAGCCATGAACAGGCACAGCAACGCATG
GCGCGATGGCTGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A808FED4

Antitoxin

Source ID Structure
AlphaFold DB A0A828YMS8

References