Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 19235..19902 Replicon plasmid unnameda
Accession NZ_CP029265
Organism Xanthomonas citri pv. fuscans strain PR8F

Toxin (Protein)


Gene name vapC Uniprot ID A0A3T0G501
Locus tag DGN16_RS22525 Protein ID WP_022557732.1
Coordinates 19486..19902 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U4M4Z6
Locus tag DGN16_RS22520 Protein ID WP_022557731.1
Coordinates 19235..19489 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DGN16_RS22505 (DGN16_23500) 14413..15371 - 959 Protein_16 IS3-like element ISXcd1 family transposase -
DGN16_RS22510 (DGN16_23505) 15404..18433 - 3030 WP_022560486.1 Tn3 family transposase -
DGN16_RS22515 (DGN16_23510) 18430..19023 - 594 WP_022560487.1 recombinase family protein -
DGN16_RS22520 (DGN16_23515) 19235..19489 + 255 WP_022557731.1 plasmid stability protein Antitoxin
DGN16_RS22525 (DGN16_23520) 19486..19902 + 417 WP_022557732.1 type II toxin-antitoxin system VapC family toxin Toxin
DGN16_RS22530 (DGN16_23525) 19916..20470 + 555 WP_033482006.1 plasmid pRiA4b ORF-3 family protein -
DGN16_RS22535 (DGN16_23530) 20545..20682 - 138 Protein_22 transposase -
DGN16_RS22540 (DGN16_23535) 20731..21279 - 549 WP_022557734.1 DNA topoisomerase -
DGN16_RS22545 (DGN16_23540) 21434..22726 - 1293 WP_033481893.1 M12 family metallo-peptidase -
DGN16_RS22550 (DGN16_23545) 22853..24172 - 1320 WP_022557736.1 right-handed parallel beta-helix repeat-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..50275 50275
- inside IScluster/Tn - - 11716..20682 8966


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-128)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14833.04 Da        Isoelectric Point: 4.6812

>T105370 WP_022557732.1 NZ_CP029265:19486-19902 [Xanthomonas citri pv. fuscans]
MIVLDTNVVSEAMKPEPHPSVRTWLNDQAAETLYLSSVTLAELLFGIAALPAGKRKDMLEQALDGLMGLFRDRVLPFDID
AARRYAELAVTAKIGGRGFPTPDGYIAAIAASRGFIVASRDTAPYEAAGVTVINPWEG

Download         Length: 417 bp

>T105370 NZ_CP029265:19486-19902 [Xanthomonas citri pv. fuscans]
ATGATCGTTCTCGATACCAACGTCGTTTCCGAGGCGATGAAGCCCGAGCCGCACCCATCCGTGCGGACCTGGTTGAACGA
TCAAGCCGCTGAAACACTGTACCTGTCCAGCGTGACGCTGGCCGAACTGCTATTTGGCATCGCTGCGCTTCCTGCCGGTA
AGCGCAAGGACATGCTGGAACAGGCCCTTGATGGCCTCATGGGCCTGTTTAGGGATCGGGTGTTGCCATTCGACATCGAT
GCAGCGCGGCGTTATGCCGAATTGGCCGTGACGGCAAAGATCGGAGGGCGAGGATTTCCGACACCCGACGGCTACATCGC
AGCGATTGCTGCCTCGCGGGGTTTCATTGTGGCGTCACGCGACACGGCCCCTTACGAAGCGGCCGGCGTAACCGTCATCA
ATCCGTGGGAAGGGTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9388.80 Da        Isoelectric Point: 8.9326

>AT105370 WP_022557731.1 NZ_CP029265:19235-19489 [Xanthomonas citri pv. fuscans]
MAMLTVRNLPDDVHRALRMRAAQNGHSTEAEVREILATAVKPETRVRLGEALAALGRKIGLTNEDFEVFDRVRDKTPAVP
PRLE

Download         Length: 255 bp

>AT105370 NZ_CP029265:19235-19489 [Xanthomonas citri pv. fuscans]
ATGGCAATGCTGACAGTACGTAATCTGCCGGATGATGTGCACCGCGCATTGCGCATGCGGGCCGCTCAAAATGGGCACAG
CACCGAGGCCGAGGTCCGCGAGATTCTGGCGACCGCAGTCAAGCCAGAGACGCGCGTTCGCCTAGGCGAAGCCTTGGCGG
CTTTGGGTCGCAAGATTGGCCTGACGAATGAGGACTTCGAGGTCTTCGATCGGGTAAGAGACAAGACGCCGGCCGTCCCG
CCGAGGCTTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T0G501

Antitoxin

Source ID Structure
AlphaFold DB A0A3T0G545

References