Detailed information of TA system TA105356

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 4544031..4544638
• Replicon: chromosome
• Accession: NZ_CP029246
• Organism: Enterobacter hormaechei subsp. xiangfangensis strain OSUVMCKPC4-2

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A4Q4AAS0
• Locus tag: DF208_RS22770
• Protein ID: WP_057979982.1
• Coordinates: 4544453..4544638 (-)
• Length: 62 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: DF208_RS22765
• Protein ID: WP_023315016.1
• Coordinates: 4544031..4544438 (-)
• Length: 136 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DF208_RS22750	4540774..4542027	+	1254	WP_015572749.1	valine--pyruvate transaminase	-
DF208_RS22755	4542035..4542490	-	456	WP_023323869.1	4Fe-4S dicluster domain-containing protein	-
DF208_RS22760	4542951..4544027	+	1077	WP_023323870.1	type I restriction enzyme HsdR N-terminal domain-containing protein	-
DF208_RS22765	4544031..4544438	-	408	WP_023315016.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
DF208_RS22770	4544453..4544638	-	186	WP_057979982.1	type II toxin-antitoxin system HicA family toxin	Toxin
DF208_RS22775	4544888..4546426	-	1539	WP_006808612.1	aldehyde dehydrogenase AldB	-
DF208_RS22780	4546593..4547477	+	885	WP_003860164.1	ROK family protein	-
DF208_RS22785	4547481..4549319	-	1839	WP_023323871.1	selenocysteine-specific translation elongation factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-129)

Sequences

Toxin

Protein

• Length: 62 a.a.
• Molecular weight: 6852.08 Da
• Isoelectric Point: 11.5191

>T105356 WP_057979982.1 NZ_CP029246:c4544638-4544453 [Enterobacter hormaechei subsp. xiangfangensis]
VKSADIITVLVSHGWKCVRTKGSHHQFRHPVQKGLVTVPHPKKDIKPGTLAQIWRQAGIKH

Nucleotide

• Length: 186 bp

>T105356 NZ_CP029246:c4544638-4544453 [Enterobacter hormaechei subsp. xiangfangensis]
GTGAAAAGTGCGGATATCATTACTGTTCTGGTTAGCCATGGCTGGAAATGTGTAAGAACGAAGGGAAGCCATCATCAGTT
TCGCCATCCAGTGCAAAAAGGGTTGGTTACCGTCCCACATCCTAAAAAGGACATTAAACCAGGCACTCTCGCACAAATCT
GGCGACAGGCGGGAATTAAACACTGA

Antitoxin

Protein

• Length: 136 a.a.
• Molecular weight: 15205.20 Da
• Isoelectric Point: 4.5036

>AT105356 WP_023315016.1 NZ_CP029246:c4544438-4544031 [Enterobacter hormaechei subsp. xiangfangensis]
MFYPAYIHSDSDGSASGFFPDVPGCFFAGDSLDDAFQDARDALTAHFEALFEMDEMLPLPGMVEAHLASHPEDFIGGQWL
LVDINMKQFEGRVERINITIPRRLLVKIDSFVSEHPQFTNRSAFLAEAARRVLPR

Nucleotide

• Length: 408 bp

>AT105356 NZ_CP029246:c4544438-4544031 [Enterobacter hormaechei subsp. xiangfangensis]
ATGTTTTATCCGGCTTACATTCATTCTGATTCCGACGGTAGCGCCAGTGGTTTCTTTCCTGACGTTCCGGGGTGTTTTTT
TGCGGGGGATTCACTGGATGATGCTTTTCAGGATGCACGTGATGCATTAACTGCCCATTTTGAAGCGTTGTTTGAAATGG
ATGAAATGTTGCCACTTCCGGGTATGGTTGAAGCGCATCTGGCAAGTCATCCGGAGGATTTCATTGGCGGACAATGGTTG
CTGGTGGATATCAATATGAAACAGTTTGAAGGCAGAGTAGAGCGCATCAATATTACGATACCTCGCCGTTTGCTGGTGAA
GATTGATTCCTTTGTCAGCGAGCATCCACAATTTACTAACCGAAGTGCTTTTCTTGCAGAGGCAGCACGGCGTGTACTGC
CCCGGTGA

Structures

Toxin

• AlphaFold DB: A0A4Q4AAS0