Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 214147..215769 Replicon plasmid pTB101
Accession NZ_CP029211
Organism Aquabacterium olei strain NBRC 110486

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag DEH84_RS18295 Protein ID WP_109038645.1
Coordinates 214147..215496 (-) Length 450 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag DEH84_RS18300 Protein ID WP_109038646.1
Coordinates 215500..215769 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DEH84_RS18270 209723..210439 + 717 WP_109038640.1 Crp/Fnr family transcriptional regulator -
DEH84_RS18275 210436..211665 + 1230 WP_109038641.1 NnrS family protein -
DEH84_RS18280 211666..212130 - 465 WP_109038642.1 SCP2 sterol-binding domain-containing protein -
DEH84_RS18285 212127..213050 - 924 WP_109038643.1 U32 family peptidase -
DEH84_RS18290 213047..214060 - 1014 WP_109038644.1 U32 family peptidase -
DEH84_RS18295 214147..215496 - 1350 WP_109038645.1 type II toxin-antitoxin system HipA family toxin Toxin
DEH84_RS18300 215500..215769 - 270 WP_109038646.1 helix-turn-helix domain-containing protein Antitoxin
DEH84_RS18305 215909..216259 + 351 WP_109038647.1 ArsR family transcriptional regulator -
DEH84_RS18310 216272..216775 + 504 WP_109038648.1 VOC family protein -
DEH84_RS18315 216785..217279 + 495 WP_109038649.1 arsenate reductase ArsC -
DEH84_RS18320 217286..217789 + 504 WP_109038650.1 arsenate reductase ArsC -
DEH84_RS18325 217800..218831 + 1032 WP_109038651.1 ACR3 family arsenite efflux transporter -
DEH84_RS18330 218847..219470 - 624 WP_109038652.1 LysE family transporter -
DEH84_RS18335 219517..220269 - 753 WP_109038653.1 anaerobic ribonucleoside-triphosphate reductase activating protein -
DEH84_RS18340 220220..220411 - 192 WP_109038654.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..366221 366221


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(12-111)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-67)


Sequences

Toxin        


Download         Length: 450 a.a.        Molecular weight: 49382.69 Da        Isoelectric Point: 8.2771

>T105227 WP_109038645.1 NZ_CP029211:c215496-214147 [Aquabacterium olei]
MGRLSHTRTLGLWMNGERVGVWRVSPNAPDTLQYDPAWMASSQGRPLSLSLPFTPGNAPHRGPAVRAYFENLLPDSKDIR
ERMAHRFQVGSTEAFALLAEVGRDCVGALEILPEGTPAAGVAPLQAEALTEARVAQVLRSATTSRPLGWSGEADDFRISI
AGAQEKTALLWHDGRWCLPRGHTPTTHIFKLPLGLIGGMRLDMRHSVENEWLCALILQAFGVPVAACQPAQFEEFKVLVV
ERFDRAWWTSPAGDRRLLRLPQEDLCQATGVPPEAKYEADGGPGIDRILDVLDGSMNRELDRRTFFLAQLLFWMLCAPDG
HAKNFSLFLRPGGRYQLTPLYDVLSAYPVLGGGPGQIAPLRARMAMAVRARNAHWHRRDILRRHWVALGTRHGVLTEEGR
EVSHLIDAVVTRTPAVVAAVQAKLPAGFPAQVADTILDGLQDAARRLAG

Download         Length: 1350 bp

>T105227 NZ_CP029211:c215496-214147 [Aquabacterium olei]
ATGGGCCGTCTCTCGCACACCCGCACGCTTGGCCTCTGGATGAACGGCGAGCGCGTCGGGGTCTGGCGCGTGTCCCCGAA
CGCGCCGGACACGCTGCAGTACGACCCCGCCTGGATGGCCTCGTCGCAGGGGCGACCGCTTTCACTGTCGCTGCCCTTCA
CCCCGGGGAACGCCCCGCACCGTGGCCCGGCCGTGCGCGCCTACTTCGAGAACCTGCTGCCCGACAGCAAGGACATCCGC
GAGCGCATGGCGCACCGATTTCAGGTCGGCTCCACCGAAGCGTTTGCCTTGCTGGCCGAGGTGGGGCGCGACTGCGTGGG
CGCCCTGGAGATCCTGCCGGAAGGCACCCCGGCCGCCGGGGTGGCGCCATTACAGGCCGAAGCGTTGACGGAAGCCCGGG
TCGCGCAGGTGCTGCGCAGTGCCACCACCTCGCGGCCGCTGGGATGGTCAGGCGAGGCCGACGACTTCCGCATCTCGATT
GCCGGTGCGCAGGAGAAGACGGCCCTGCTGTGGCATGACGGACGGTGGTGCCTGCCACGCGGCCACACGCCCACCACGCA
CATCTTCAAGCTGCCTTTGGGACTGATCGGTGGCATGCGCCTGGACATGCGCCACTCGGTGGAAAACGAGTGGTTGTGCG
CCCTGATTCTTCAGGCCTTTGGCGTGCCGGTGGCCGCGTGTCAGCCGGCGCAGTTCGAGGAGTTCAAGGTGCTGGTGGTC
GAGCGCTTCGACCGGGCCTGGTGGACGTCGCCGGCCGGAGACCGCCGGCTTCTGCGTCTGCCGCAGGAGGACCTGTGCCA
GGCCACCGGCGTGCCCCCCGAGGCGAAGTACGAGGCCGACGGCGGGCCCGGCATCGACCGCATCCTCGATGTGCTGGATG
GATCGATGAACCGGGAGCTCGATCGGCGCACTTTCTTTCTGGCGCAGCTGCTCTTCTGGATGCTGTGCGCCCCCGATGGG
CATGCCAAGAACTTCAGCCTGTTTCTTCGCCCGGGCGGCCGCTACCAGCTGACGCCGCTGTACGACGTGCTATCGGCCTA
TCCGGTGCTGGGCGGTGGCCCGGGGCAGATCGCGCCGCTGCGCGCCCGGATGGCCATGGCGGTGCGCGCGCGCAACGCCC
ATTGGCATCGGCGCGACATCCTGCGTCGCCACTGGGTGGCGCTCGGCACGCGGCACGGGGTGCTGACCGAGGAAGGCCGT
GAAGTGTCGCATCTGATCGACGCGGTGGTGACCCGCACGCCGGCGGTGGTGGCGGCCGTGCAGGCGAAGCTGCCGGCTGG
ATTTCCTGCGCAGGTGGCTGACACCATCCTCGACGGCCTGCAGGATGCGGCCCGACGCCTGGCCGGCTGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9624.24 Da        Isoelectric Point: 10.8171

>AT105227 WP_109038646.1 NZ_CP029211:c215769-215500 [Aquabacterium olei]
MPQFPLRTAAQLPPLLQAFRKAAGLTQREVALRLGVSQQTYSAMERNADKVGAARLLKLLHILGVEVVLAQPVQAAPAHS
DTGTDKPVW

Download         Length: 270 bp

>AT105227 NZ_CP029211:c215769-215500 [Aquabacterium olei]
ATGCCCCAGTTCCCCCTCCGCACCGCGGCCCAGTTGCCGCCCTTGCTGCAGGCCTTTCGCAAGGCAGCCGGTCTCACGCA
GCGTGAGGTGGCACTGCGCCTGGGCGTGTCACAGCAAACGTACTCCGCCATGGAGCGCAATGCCGACAAGGTGGGGGCGG
CGAGGCTGCTCAAGCTGCTGCACATCCTCGGCGTGGAAGTGGTGCTGGCCCAGCCGGTGCAGGCCGCGCCGGCTCATTCG
GACACCGGCACCGACAAGCCGGTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References