Detailed information of TA system TA105225

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-Xre
• Location: 26354..27230
• Replicon: plasmid pOM-1
• Accession: NZ_CP029209
• Organism: Nitratireductor sp. OM-1

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: DEJ54_RS19280
• Protein ID: WP_113156418.1
• Coordinates: 26718..27230 (+)
• Length: 171 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: DEJ54_RS19275
• Protein ID: WP_113156417.1
• Coordinates: 26354..26725 (+)
• Length: 124 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DEJ54_RS19260	22265..23515	+	1251	WP_113157090.1	plasmid partitioning protein RepA	-
DEJ54_RS19265	23512..24654	+	1143	WP_113156415.1	plasmid partitioning protein RepB	-
DEJ54_RS19270	24884..26266	+	1383	WP_113156416.1	replication initiation protein	-
DEJ54_RS19275	26354..26725	+	372	WP_113156417.1	MbcA/ParS/Xre antitoxin family protein	Antitoxin
DEJ54_RS19280	26718..27230	+	513	WP_113156418.1	RES domain-containing protein	Toxin
DEJ54_RS19285	27277..27525	-	249	WP_113156419.1	WGR domain-containing protein	-
DEJ54_RS19290	27708..28883	-	1176	WP_113156420.1	tyrosine-type recombinase/integrase	-
DEJ54_RS19295	29081..29635	-	555	Protein_25	IS6 family transposase	-
DEJ54_RS19300	29647..29834	-	188	Protein_26	transposase domain-containing protein	-
DEJ54_RS19305	29838..29955	+	118	Protein_27	transposase	-
DEJ54_RS19310	30047..30807	+	761	WP_113156421.1	IS5 family transposase	-
DEJ54_RS19315	30878..31849	-	972	WP_113156422.1	LysR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..857937	857937

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (9-162)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (71-120)

Sequences

Toxin

Protein

• Length: 171 a.a.
• Molecular weight: 18670.02 Da
• Isoelectric Point: 5.9132

>T105225 WP_113156418.1 NZ_CP029209:26718-27230 [Nitratireductor sp. OM-1]
MPEELRNETLWRAYVPRWAHAPLSGEGAARFGGRWNPVGAATIYAARELSTAWAEYNQGFVQHPALIAQLTLSKARLADL
TSEEGLEAVGQSPALHQCEWRADVDAGKLPETHLLREKLLLQGYHGVIYPSFMSPGGSCVALWSWNGEKGPGLSVTDPEH
RLPNDAASWL

Nucleotide

• Length: 513 bp

>T105225 NZ_CP029209:26718-27230 [Nitratireductor sp. OM-1]
ATGCCTGAAGAATTGCGCAATGAGACCCTTTGGCGGGCCTATGTGCCACGTTGGGCGCATGCGCCGCTTTCAGGGGAGGG
GGCCGCACGCTTTGGCGGTCGCTGGAACCCGGTTGGAGCAGCCACGATCTACGCGGCGCGGGAGCTTTCCACGGCCTGGG
CTGAATATAATCAGGGATTTGTGCAGCACCCCGCACTGATCGCCCAGCTGACGCTTTCAAAAGCGCGCCTTGCGGATCTG
ACGAGCGAAGAGGGGCTTGAGGCAGTCGGGCAATCGCCAGCTTTGCATCAGTGCGAGTGGCGGGCGGATGTGGATGCCGG
AAAGCTGCCCGAAACCCATCTCCTGCGCGAAAAACTGCTTCTGCAAGGCTATCACGGCGTGATCTATCCATCCTTCATGT
CGCCCGGCGGAAGCTGCGTCGCGCTGTGGAGCTGGAATGGAGAGAAAGGACCCGGTCTTTCCGTGACGGATCCCGAGCAC
AGACTGCCAAATGACGCGGCTTCCTGGCTTTAG

Antitoxin

Protein

• Length: 124 a.a.
• Molecular weight: 13323.41 Da
• Isoelectric Point: 8.5338

>AT105225 WP_113156417.1 NZ_CP029209:26354-26725 [Nitratireductor sp. OM-1]
MTAAELDFAAAHFADERAPFLSARRVSELLGVTMVELARLIGVARNTLTAKSGQRKVDQALSPVVRILAMATEMAGDEHR
AVIWFKHQPIPGWAGKTAYDLVGEGKADKVLTYLEAVRAGVYA

Nucleotide

• Length: 372 bp

>AT105225 NZ_CP029209:26354-26725 [Nitratireductor sp. OM-1]
ATGACTGCGGCAGAACTCGATTTCGCAGCGGCCCATTTCGCTGACGAACGCGCACCGTTTCTATCCGCCCGGCGGGTTTC
TGAACTTCTGGGCGTGACAATGGTGGAGCTCGCACGGCTGATTGGCGTTGCCCGCAACACGCTGACGGCCAAATCCGGCC
AGAGAAAGGTTGATCAGGCGCTGAGCCCGGTTGTGCGCATTCTGGCAATGGCGACGGAAATGGCCGGAGATGAGCACCGG
GCCGTGATCTGGTTCAAGCATCAGCCCATTCCCGGCTGGGCGGGAAAAACCGCCTATGATCTGGTAGGGGAGGGGAAGGC
CGACAAGGTTTTGACCTATCTCGAAGCGGTGCGTGCCGGCGTCTATGCCTGA