Detailed information of TA system TA105223

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): abiEi-abiEii/AbiEii-AbiEi
• Location: 52907..54339
• Replicon: chromosome
• Accession: NZ_CP029207
• Organism: Streptococcus constellatus strain TCV107

Toxin (Protein)

• Gene name: abiEi
• Uniprot ID: -
• Locus tag: DEH83_RS00220
• Protein ID: WP_255776772.1
• Coordinates: 53494..54339 (+)
• Length: 282 a.a.

Antitoxin (Protein)

• Gene name: abiEii
• Uniprot ID: -
• Locus tag: DEH83_RS00215
• Protein ID: WP_255776771.1
• Coordinates: 52907..53497 (+)
• Length: 197 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DEH83_RS00210 (DEH83_00205)	48886..52713	-	3828	WP_255776770.1	GbpC/Spa domain-containing protein	-
DEH83_RS00215 (DEH83_00210)	52907..53497	+	591	WP_255776771.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
DEH83_RS00220 (DEH83_00215)	53494..54339	+	846	WP_255776772.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
DEH83_RS00225 (DEH83_00225)	54712..55349	-	638	Protein_44	hypothetical protein	-
DEH83_RS00230 (DEH83_00230)	55464..56468	-	1005	WP_255776773.1	Abi family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (33-259)

Antitoxin

• Transcriptional regulator, AbiEi antitoxin (6-51)

Sequences

Toxin

Protein

• Length: 282 a.a.
• Molecular weight: 32537.00 Da
• Isoelectric Point: 5.4079

>T105223 WP_255776772.1 NZ_CP029207:53494-54339 [Streptococcus constellatus]
VNKAKLTALCHKISKNTGLTFNSVMTYYFLEAILKKLSQSSYSNHYIFKGGFLLSNVIGVESRSTADIDFLFHKQTLSEE
NIQQQLEEILTEAKDGIQFSIQSITAIKESDDYGGYRATILCQLENIKQIIHLDIATGDIVTPYPVTYDYKAIFDDGNFP
IIAYTIETILTEKLQTIYSRNFLNSRSKDFYDVYILSKLKKDDIDFLQLKVACERTFSYRETELDFNKIIELLERFKSDS
VQQQQWQNYSKKYSYTKDILFTDILNEIISLLITLNSNHNA

Nucleotide

• Length: 846 bp

>T105223 NZ_CP029207:53494-54339 [Streptococcus constellatus]
GTGAATAAAGCAAAATTAACAGCACTCTGCCATAAAATATCGAAGAATACTGGATTAACTTTTAATTCCGTCATGACCTA
TTACTTTCTTGAAGCTATTCTGAAAAAATTAAGTCAGAGTTCTTATTCAAATCACTATATTTTCAAAGGTGGGTTCCTAC
TTTCAAACGTCATTGGGGTCGAATCTCGTAGTACGGCGGATATTGACTTCCTGTTTCATAAACAAACTTTATCAGAAGAA
AATATTCAACAACAACTTGAAGAAATTTTAACTGAAGCGAAAGATGGTATTCAATTTTCAATTCAATCCATAACAGCTAT
TAAGGAAAGCGATGATTATGGTGGTTATCGAGCAACCATCTTATGTCAACTAGAAAATATTAAACAAATTATCCATTTAG
ATATTGCGACTGGAGACATTGTCACACCTTACCCTGTTACCTATGACTATAAAGCCATTTTTGATGATGGCAATTTTCCA
ATCATTGCTTATACGATTGAAACAATCTTAACTGAAAAACTCCAAACCATTTATTCACGAAATTTCTTGAACAGTCGCAG
CAAAGATTTTTACGATGTCTATATCCTTTCAAAGCTAAAGAAAGATGACATTGATTTTTTACAATTAAAGGTTGCTTGTG
AAAGAACCTTTTCCTATCGTGAAACTGAACTCGATTTCAATAAAATCATTGAACTACTGGAGAGATTCAAATCTGACTCT
GTTCAACAGCAACAATGGCAAAATTATTCAAAAAAATATAGTTATACAAAAGACATTCTATTCACAGATATACTTAATGA
GATTATCAGCCTCCTGATAACTCTCAATTCTAATCATAACGCTTAA

Antitoxin

Protein

• Length: 197 a.a.
• Molecular weight: 23082.63 Da
• Isoelectric Point: 8.3535

>AT105223 WP_255776771.1 NZ_CP029207:52907-53497 [Streptococcus constellatus]
MSKKELLLEYLDSHNGMITYRDCKKLGIPTIYLTRLENEGVIFRVDKGIYLSSSGDYDEYYFFQYRYPRTVFSHISALYL
QGLTDEIPQYFEVTVPKDYRFRNTPLNLNIHTISKDIVNLGVISVKTPMGNTVNVYNFERVLCDFILNRDSIDTELFVKT
LQTYSNFPKRNLAKIYKYATKMNILDEVKRTLEVLM

Nucleotide

• Length: 591 bp

>AT105223 NZ_CP029207:52907-53497 [Streptococcus constellatus]
ATGTCCAAAAAAGAATTGTTACTTGAGTACTTAGACAGTCACAATGGCATGATTACTTATAGAGATTGTAAAAAATTAGG
TATTCCAACCATTTATCTAACTAGACTAGAAAACGAAGGGGTTATCTTTAGGGTCGATAAAGGAATCTATCTGTCCTCTA
GTGGAGATTATGATGAATACTATTTCTTTCAGTATCGTTACCCCAGAACTGTTTTTTCTCATATCTCTGCTCTTTATCTA
CAGGGACTTACAGATGAAATTCCTCAATATTTTGAAGTAACAGTTCCAAAGGACTACCGTTTTAGGAATACACCATTAAA
TTTAAATATTCACACTATTTCTAAAGATATTGTCAACCTAGGGGTCATCAGTGTAAAAACTCCAATGGGAAACACCGTTA
ACGTTTATAATTTTGAACGTGTTCTGTGTGATTTTATCCTTAATCGAGATAGCATTGATACTGAGCTATTTGTTAAAACA
CTTCAAACTTATAGCAACTTCCCTAAAAGAAATCTCGCAAAGATCTATAAATATGCTACAAAAATGAATATCTTAGATGA
AGTTAAACGAACTCTGGAGGTTCTAATGTGA