Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sezT-pezT/zeta-couple_hipB
Location 30978..32209 Replicon chromosome
Accession NZ_CP029207
Organism Streptococcus constellatus strain TCV107

Toxin (Protein)


Gene name sezT Uniprot ID -
Locus tag DEH83_RS00130 Protein ID WP_255776762.1
Coordinates 30978..31733 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name pezT Uniprot ID -
Locus tag DEH83_RS00135 Protein ID WP_255776763.1
Coordinates 31733..32209 (-) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DEH83_RS00110 (DEH83_00115) 26150..28813 - 2664 WP_255776753.1 AAA family ATPase -
DEH83_RS00115 (DEH83_00120) 28810..29505 - 696 WP_255776759.1 hypothetical protein -
DEH83_RS00120 29507..30139 - 633 WP_255776760.1 hypothetical protein -
DEH83_RS00125 30129..30914 - 786 WP_255776761.1 hypothetical protein -
DEH83_RS00130 (DEH83_00130) 30978..31733 - 756 WP_255776762.1 type II toxin-antitoxin system toxin PezT Toxin
DEH83_RS00135 (DEH83_00135) 31733..32209 - 477 WP_255776763.1 type II toxin-antitoxin system antitoxin PezA Antitoxin
DEH83_RS00140 (DEH83_00140) 32303..32566 - 264 WP_255776764.1 hypothetical protein -
DEH83_RS00145 (DEH83_00145) 32610..32999 - 390 WP_058669452.1 DUF5945 family protein -
DEH83_RS00150 (DEH83_00150) 32996..33223 - 228 WP_007520115.1 DUF5965 family protein -
DEH83_RS00155 (DEH83_00155) 33278..34366 - 1089 WP_255776765.1 toprim domain-containing protein -
DEH83_RS00160 (DEH83_00160) 34405..35043 - 639 WP_003036847.1 hypothetical protein -
DEH83_RS00165 (DEH83_00165) 35178..36128 + 951 WP_255776766.1 ATP-grasp domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-214)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28749.63 Da        Isoelectric Point: 6.7716

>T105222 WP_255776762.1 NZ_CP029207:c31733-30978 [Streptococcus constellatus]
MTLSEFSEAEFQKALKRNIRALTRGKTVSLHPQAVLLCGQSGAGKTTIHRIKQKEFQGNIIIIDGDSFRSQHPNYLALQE
EYGKDSVDYTKDFAGKMVEHLIDEFSKQSYHLLIEGTLRTTEVPRKTVQLLATRGYQVSLALIATKPELSYLSTLIHYEE
LYTIDPSQARATPKEHHDMIVSNFVSNTRQLEQLGIFARMQIYQRDRTCVYDSRDDESSAADVLHDLLFGEWSQVEKEML
KVGEEKLKSYK

Download         Length: 756 bp

>T105222 NZ_CP029207:c31733-30978 [Streptococcus constellatus]
ATGACTTTATCAGAATTTAGTGAGGCGGAGTTTCAAAAAGCTTTAAAGCGTAATATTCGTGCCTTAACTCGTGGAAAAAC
AGTCTCGCTACATCCTCAAGCAGTTCTGCTTTGTGGTCAAAGTGGAGCTGGAAAGACGACTATTCATCGGATCAAGCAAA
AGGAATTTCAAGGAAATATCATCATTATTGACGGAGACAGCTTCCGTTCGCAGCATCCAAATTATCTGGCTTTGCAGGAA
GAGTATGGTAAAGATAGCGTTGATTATACCAAAGATTTTGCGGGGAAGATGGTTGAACACCTCATTGATGAATTCAGCAA
ACAAAGCTATCATTTATTAATTGAGGGAACACTAAGAACAACAGAAGTCCCCCGAAAAACGGTACAATTATTGGCAACTA
GAGGCTATCAAGTCTCACTTGCACTGATTGCGACTAAGCCAGAATTGTCCTATCTCAGCACTTTGATACATTATGAAGAG
CTCTATACTATAGATCCTAGTCAAGCTAGAGCAACTCCAAAAGAACATCATGACATGATAGTGAGCAATTTCGTTAGTAA
CACCCGACAACTGGAGCAATTAGGTATCTTTGCACGAATGCAAATCTATCAACGAGATAGAACTTGTGTTTATGATTCAA
GAGATGATGAAAGTTCAGCAGCAGATGTTCTTCACGACCTATTGTTTGGCGAGTGGAGTCAGGTAGAGAAAGAGATGTTG
AAGGTGGGGGAAGAGAAGTTGAAAAGTTACAAGTAA

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18041.42 Da        Isoelectric Point: 4.5292

>AT105222 WP_255776763.1 NZ_CP029207:c32209-31733 [Streptococcus constellatus]
MIGDNIKSLRKTHDLTQPEFAKIVGISRNSLSRYENGTSSVSTELIDRICQKFNVSYVDIVGEDKLMTPVEDYQLTLKIE
VLKERGSTILSKLYRYQDGKGIAFDDESNPWILISDDVADLVNTKIYLVDTFEEIERYNGYLDGIERMLNLANHQVVA

Download         Length: 477 bp

>AT105222 NZ_CP029207:c32209-31733 [Streptococcus constellatus]
ATGATTGGAGATAATATTAAGTCCTTACGAAAAACTCATGATTTAACCCAGCCAGAATTCGCAAAAATTGTCGGAATTTC
TCGCAATAGTCTAAGTCGATATGAGAATGGAACCAGCTCTGTTTCAACCGAACTCATTGATCGGATTTGTCAGAAATTCA
ATGTCTCCTATGTCGATATTGTCGGAGAAGATAAGCTGATGACTCCCGTAGAAGATTATCAGCTAACCTTAAAAATTGAA
GTTTTGAAAGAACGTGGCTCCACTATTCTTTCAAAACTGTATCGATATCAAGATGGGAAAGGGATTGCATTTGACGATGA
ATCGAATCCGTGGATTTTGATAAGTGATGATGTAGCAGATTTAGTGAATACCAAGATTTATCTTGTCGATACCTTTGAAG
AGATAGAGCGTTACAATGGCTATTTAGATGGCATTGAGCGGATGTTAAACCTTGCCAATCACCAGGTGGTGGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References