Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-stbD/ParE-DnaT
Location 543908..544443 Replicon chromosome
Accession NZ_CP029206
Organism Actinobacillus porcitonsillarum strain 9953L55

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag DDU33_RS02800 Protein ID WP_108923018.1
Coordinates 543908..544192 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID -
Locus tag DDU33_RS02805 Protein ID WP_108923020.1
Coordinates 544189..544443 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DDU33_RS02765 538938..539489 + 552 WP_108923003.1 acetyltransferase -
DDU33_RS02775 539639..540763 + 1125 WP_208620294.1 alpha/beta hydrolase -
DDU33_RS02780 540921..541763 + 843 WP_108923009.1 PhzF family phenazine biosynthesis protein -
DDU33_RS02785 541844..542635 - 792 WP_108923011.1 4,5-DOPA dioxygenase extradiol -
DDU33_RS02790 542784..543242 + 459 WP_108923013.1 hypothetical protein -
DDU33_RS02795 543319..543762 - 444 WP_108923016.1 ester cyclase -
DDU33_RS02800 543908..544192 - 285 WP_108923018.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DDU33_RS02805 544189..544443 - 255 WP_108923020.1 plasmid stabilization protein Antitoxin
DDU33_RS02810 544608..545813 - 1206 WP_108923022.1 ATP-binding protein -
DDU33_RS02815 545927..546817 - 891 WP_108923024.1 LysR family transcriptional regulator -
DDU33_RS02820 546927..547760 + 834 WP_108923026.1 MBL fold metallo-hydrolase -
DDU33_RS02825 547787..548878 + 1092 WP_108923028.1 ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11188.17 Da        Isoelectric Point: 10.6258

>T105219 WP_108923018.1 NZ_CP029206:c544192-543908 [Actinobacillus porcitonsillarum]
MTYRVVFRKEALKEFQKLDKVIANQFLDKLQERIEQPRVPSAKLRGMKDCYKIKLRSSGYRLVYQVVDEQIVIQVVAVGR
RDRSDVYQKAQLRL

Download         Length: 285 bp

>T105219 NZ_CP029206:c544192-543908 [Actinobacillus porcitonsillarum]
ATGACTTATCGTGTGGTATTCCGGAAAGAGGCTCTTAAAGAGTTTCAGAAGTTGGATAAGGTAATTGCCAATCAATTTTT
AGATAAACTTCAAGAACGTATAGAACAGCCGAGAGTACCAAGTGCCAAACTTCGCGGTATGAAAGATTGTTACAAAATCA
AATTGAGAAGTTCCGGCTATCGTTTGGTTTATCAAGTGGTTGATGAACAGATTGTTATTCAAGTGGTCGCAGTAGGCAGG
CGTGATCGAAGTGATGTCTACCAAAAAGCACAGCTGCGTTTATGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9416.66 Da        Isoelectric Point: 4.0202

>AT105219 WP_108923020.1 NZ_CP029206:c544443-544189 [Actinobacillus porcitonsillarum]
MPSIVLTNTVASITELKTNPMATFNAAGGEAIAILNRNEPAFYCVPPHIYEYLIELADDAELARIVEERQNDELVEVNLE
DLRR

Download         Length: 255 bp

>AT105219 NZ_CP029206:c544443-544189 [Actinobacillus porcitonsillarum]
ATGCCAAGTATCGTTTTAACCAATACCGTTGCGAGTATTACTGAACTAAAAACCAATCCTATGGCAACATTTAACGCGGC
AGGCGGTGAAGCGATTGCCATTTTAAACCGTAATGAACCTGCATTTTATTGTGTTCCTCCACATATTTATGAATATCTCA
TTGAGTTGGCAGATGATGCCGAGCTGGCAAGAATTGTGGAAGAACGCCAAAATGATGAGTTAGTTGAAGTGAATTTAGAG
GATTTACGCCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References