105196

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 928600..929077 Replicon chromosome
Accession NZ_CP029198
Organism Staphylococcus aureus strain aureus

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag FORC090_RS04570 Protein ID WP_000052076.1
Coordinates 928600..928788 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag FORC090_RS04575 Protein ID WP_001059690.1
Coordinates 928817..929077 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC090_RS04540 924594..925115 + 522 WP_000824482.1 hypothetical protein -
FORC090_RS04545 925456..926142 + 687 WP_000141557.1 thermonuclease family protein -
FORC090_RS04550 926499..926699 + 201 WP_001059082.1 cold-shock protein -
FORC090_RS04555 927191..927409 - 219 WP_000005886.1 hypothetical protein -
FORC090_RS04560 927471..927755 - 285 WP_001004399.1 hypothetical protein -
FORC090_RS04565 927843..928412 - 570 WP_001106654.1 hypothetical protein -
FORC090_RS04570 928600..928788 - 189 WP_000052076.1 hypothetical protein Toxin
FORC090_RS04575 928817..929077 - 261 WP_001059690.1 hypothetical protein Antitoxin
FORC090_RS04580 929418..929621 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
FORC090_RS04585 929618..929854 - 237 WP_000349581.1 hypothetical protein -
FORC090_RS04590 930079..930660 + 582 WP_175406779.1 phosphoglycerate mutase family protein -
FORC090_RS04595 930733..931350 - 618 WP_063663419.1 LysE/ArgO family amino acid transporter -
FORC090_RS04600 931505..931999 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
FORC090_RS04610 932398..932820 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
FORC090_RS04615 932968..933684 + 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-120)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(2-43)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T105196 WP_000052076.1 NZ_CP029198:c928788-928600 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T105196 NZ_CP029198:c928788-928600 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT105196 WP_001059690.1 NZ_CP029198:c929077-928817 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT105196 NZ_CP029198:c929077-928817 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References