Detailed information of TA system TA105194

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Fic(toxin)
• Location: 5419672..5420237
• Replicon: chromosome
• Accession: NZ_CP029194
• Organism: Streptomyces venezuelae strain ATCC 15068

Toxin (Protein)

• Gene name: doc
• Uniprot ID: -
• Locus tag: DEJ46_RS24905
• Protein ID: WP_055643226.1
• Coordinates: 5419866..5420237 (+)
• Length: 124 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: A0A5P2B477
• Locus tag: DEJ46_RS24900
• Protein ID: WP_055646260.1
• Coordinates: 5419672..5419869 (+)
• Length: 66 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DEJ46_RS24880	5415296..5415964	+	669	WP_150269789.1	DUF4097 family beta strand repeat protein	-
DEJ46_RS24885	5416083..5417048	+	966	WP_150269791.1	ATP-binding cassette domain-containing protein	-
DEJ46_RS24890	5417147..5417932	+	786	WP_150269793.1	ABC transporter permease	-
DEJ46_RS24895	5418136..5419638	+	1503	WP_150269795.1	MFS transporter	-
DEJ46_RS24900	5419672..5419869	+	198	WP_055646260.1	Arc family DNA-binding protein	Antitoxin
DEJ46_RS24905	5419866..5420237	+	372	WP_055643226.1	Fic family protein	Toxin
DEJ46_RS24910	5420361..5422151	+	1791	WP_150269797.1	DEAD/DEAH box helicase	-
DEJ46_RS24915	5422592..5423233	+	642	WP_017237054.1	helix-turn-helix domain-containing protein	-
DEJ46_RS24920	5423230..5424219	-	990	WP_150269799.1	winged helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Death on curing protein (16-120)

Antitoxin

• Arc-like DNA binding domain (5-43)

Sequences

Toxin

Protein

• Length: 124 a.a.
• Molecular weight: 13701.71 Da
• Isoelectric Point: 4.8500

>T105194 WP_055643226.1 NZ_CP029194:5419866-5420237 [Streptomyces venezuelae]
VTYFLTLPELLNLAGRLGASEVRDYGLLESALARPQTSVFGQDAYPEIWEKAAALMESLARNHGLVDGNKRIAWYATWVF
LHMNGHPLDPAFDVDEAEMFVLDVCQGALDVPKIAARLPRFAR

Nucleotide

• Length: 372 bp

>T105194 NZ_CP029194:5419866-5420237 [Streptomyces venezuelae]
GTGACGTACTTCCTCACGCTCCCGGAGCTCCTGAACCTCGCGGGGCGCCTCGGGGCGAGCGAGGTCCGCGACTACGGTCT
GCTGGAGTCCGCCCTGGCCCGCCCGCAGACGAGCGTGTTCGGCCAGGACGCCTATCCCGAGATCTGGGAGAAGGCCGCCG
CGCTGATGGAATCGCTCGCGCGCAACCACGGTCTCGTCGACGGAAACAAGCGCATCGCCTGGTATGCGACCTGGGTGTTC
CTCCACATGAACGGCCATCCGCTCGACCCCGCGTTCGACGTCGACGAGGCGGAGATGTTCGTCCTGGACGTGTGCCAAGG
GGCGCTCGACGTGCCCAAGATCGCAGCGCGGCTGCCGAGGTTCGCACGCTGA

Antitoxin

Protein

• Length: 66 a.a.
• Molecular weight: 7334.23 Da
• Isoelectric Point: 6.2200

>AT105194 WP_055646260.1 NZ_CP029194:5419672-5419869 [Streptomyces venezuelae]
MAGLNVRFTQEELDALRERAEAEGRSMQSFAHEAVIKAINEHSRLFNEAAEHVLKASAELNRRLA

Nucleotide

• Length: 198 bp

>AT105194 NZ_CP029194:5419672-5419869 [Streptomyces venezuelae]
ATGGCCGGTCTTAACGTGAGGTTCACCCAGGAAGAGCTGGACGCGCTGCGTGAGCGCGCCGAGGCGGAGGGCCGCAGCAT
GCAGTCCTTCGCGCACGAGGCGGTGATCAAGGCGATAAACGAACACTCCCGGCTGTTCAACGAGGCGGCCGAGCATGTCC
TGAAGGCCAGTGCGGAGCTCAACCGGAGGCTTGCGTGA

Structures

Antitoxin

• AlphaFold DB: A0A5P2B477