105193

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 5198052..5199071 Replicon chromosome
Accession NZ_CP029190
Organism Streptomyces venezuelae strain ATCC 21782

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag DEJ50_RS23395 Protein ID WP_150210042.1
Coordinates 5198052..5198609 (-) Length 186 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID -
Locus tag DEJ50_RS23400 Protein ID WP_150210044.1
Coordinates 5198613..5199071 (-) Length 153 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DEJ50_RS23365 5193667..5194914 - 1248 WP_190345022.1 hypothetical protein -
DEJ50_RS23375 5195168..5196369 - 1202 Protein_4557 site-specific integrase -
DEJ50_RS23380 5196320..5196508 - 189 WP_150210036.1 helix-turn-helix domain-containing protein -
DEJ50_RS34045 5196505..5196678 - 174 Protein_4559 replication initiation protein -
DEJ50_RS34050 5196697..5196843 - 147 Protein_4560 replication initiation protein -
DEJ50_RS34055 5196840..5196989 - 150 WP_190344656.1 hypothetical protein -
DEJ50_RS23390 5197259..5197822 + 564 WP_190344658.1 HNH endonuclease -
DEJ50_RS23395 5198052..5198609 - 558 WP_150210042.1 PIN domain-containing protein Toxin
DEJ50_RS23400 5198613..5199071 - 459 WP_150210044.1 helix-turn-helix domain-containing protein Antitoxin
DEJ50_RS23405 5199617..5199808 + 192 WP_150212310.1 hypothetical protein -
DEJ50_RS23415 5200626..5201147 + 522 WP_150210048.1 hypothetical protein -
DEJ50_RS23420 5201276..5201809 + 534 WP_150212311.1 hypothetical protein -
DEJ50_RS23425 5201817..5202044 + 228 WP_150210050.1 DUF2277 domain-containing protein -
DEJ50_RS23430 5202041..5202529 - 489 WP_150210051.1 hypothetical protein -
DEJ50_RS23435 5202713..5203342 - 630 WP_150210053.1 VTT domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

SinI-like, DNA-binding domain

(83-130)


Sequences

Toxin        


Download         Length: 186 a.a.        Molecular weight: 20451.84 Da        Isoelectric Point: 5.0485

>T105193 WP_150210042.1 NZ_CP029190:c5198609-5198052 [Streptomyces venezuelae]
MAFVAIYDANVLYPSVLRDVLIRVGAAGLVQAKWTDRILDETFRNLKAKRPDLDEGKLDRTRVAMKAAIRDCMVIGYEPL
IEAIRLPDPDDRHVLAAAIRAKAQVIVTFNLKDFPQEALAPWDVEAIHPDAFLEAQIDLNPQIIYAVLQQIADGCKKPPL
VVADLIESLERTGLVSSVAALRALS

Download         Length: 558 bp

>T105193 NZ_CP029190:c5198609-5198052 [Streptomyces venezuelae]
ATGGCTTTCGTCGCCATCTATGACGCTAATGTGCTCTACCCGAGCGTCCTGCGTGACGTGCTTATCCGTGTTGGTGCCGC
AGGCCTGGTGCAGGCGAAATGGACGGATAGAATCCTTGACGAAACTTTCCGAAACCTGAAGGCCAAAAGGCCCGATCTAG
ATGAAGGCAAACTAGATCGGACCCGCGTTGCAATGAAGGCTGCGATTCGGGACTGCATGGTCATTGGATACGAGCCCCTA
ATTGAAGCCATACGACTCCCGGATCCCGATGATCGCCACGTCCTGGCAGCAGCGATACGCGCCAAGGCTCAAGTCATTGT
CACCTTTAACCTTAAAGATTTCCCGCAAGAGGCCTTGGCCCCCTGGGATGTGGAAGCAATCCATCCAGACGCATTCCTGG
AAGCGCAGATCGACCTTAACCCGCAGATCATCTACGCTGTGCTTCAGCAGATAGCCGATGGTTGCAAGAAGCCGCCTCTT
GTGGTCGCAGACCTAATTGAGAGCCTGGAGCGCACGGGCCTCGTCTCGTCTGTGGCAGCACTGCGGGCTCTGAGCTGA

Antitoxin


Download         Length: 153 a.a.        Molecular weight: 16917.23 Da        Isoelectric Point: 5.6722

>AT105193 WP_150210044.1 NZ_CP029190:c5199071-5198613 [Streptomyces venezuelae]
MTKTDIRPVTIPPEQTASTNRALQRVRSYLEAHKDRREITVTVEDGEPEQLTLPREAVELLAGLLAHLGAGRGVSVVPAD
AELTTQQAADMLNVSRPFLVGLLNAGEIEYRHVGTHRRIKASSLMEYKQQDDLRRRTAADELTELGQEMGMM

Download         Length: 459 bp

>AT105193 NZ_CP029190:c5199071-5198613 [Streptomyces venezuelae]
ATGACCAAGACAGATATCAGGCCAGTGACGATCCCCCCGGAGCAGACCGCCTCCACCAACCGGGCCCTACAGCGTGTCCG
TAGCTACCTGGAGGCCCACAAGGACCGCCGCGAGATCACCGTCACGGTCGAGGACGGCGAGCCAGAGCAGCTGACGCTGC
CCCGTGAGGCTGTAGAGCTCCTCGCCGGCCTGCTTGCCCATCTGGGAGCAGGTCGCGGTGTCTCCGTGGTTCCAGCAGAC
GCGGAACTGACCACCCAGCAGGCGGCTGACATGCTCAACGTGTCCCGACCGTTCCTCGTGGGACTTCTCAACGCCGGTGA
GATCGAGTATCGACACGTGGGGACTCACCGCAGGATCAAGGCTTCGTCACTCATGGAGTACAAGCAGCAGGACGACCTGA
GGCGTCGCACTGCCGCCGATGAGCTCACCGAGCTCGGCCAGGAGATGGGAATGATGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References