Detailed information of TA system TA105190

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 3578775..3579409
• Replicon: chromosome
• Accession: NZ_CP029190
• Organism: Streptomyces venezuelae strain ATCC 21782

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: DEJ50_RS15720
• Protein ID: WP_150208624.1
• Coordinates: 3578987..3579409 (+)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: DEJ50_RS15715
• Protein ID: WP_079428878.1
• Coordinates: 3578775..3578990 (+)
• Length: 72 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DEJ50_RS15710	3576287..3578710	+	2424	WP_150208623.1	helicase C-terminal domain-containing protein	-
DEJ50_RS15715	3578775..3578990	+	216	WP_079428878.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
DEJ50_RS15720	3578987..3579409	+	423	WP_150208624.1	PIN domain nuclease	Toxin
DEJ50_RS15730	3580290..3580591	-	302	Protein_3065	type II toxin-antitoxin system VapC family toxin	-
DEJ50_RS15735	3580752..3581144	-	393	WP_150208625.1	SHOCT domain-containing protein	-
DEJ50_RS15740	3581299..3582513	-	1215	WP_150212161.1	MFS transporter	-
DEJ50_RS15745	3582646..3583722	+	1077	WP_190344517.1	winged helix-turn-helix transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (6-124)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (3-49)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 15337.29 Da
• Isoelectric Point: 4.7323

>T105190 WP_150208624.1 NZ_CP029190:3578987-3579409 [Streptomyces venezuelae]
VNAALYLIDTSALARFMRGDAEQYGWDQAAAAGLIATCPITELELFYSARSAADRARGIEDMRLLFGWVPVDDRAYERAW
QVQEALTKQGKHRSAGAVDLVVAATAELQGLTLLHRDHDFECIAAVTGQPLQWYGPEGGK

Nucleotide

• Length: 423 bp

>T105190 NZ_CP029190:3578987-3579409 [Streptomyces venezuelae]
GTGAACGCCGCTCTCTACCTGATCGACACCAGCGCCCTCGCCCGCTTCATGCGGGGCGACGCGGAGCAGTACGGCTGGGA
CCAGGCAGCAGCCGCCGGCCTGATCGCCACGTGCCCCATCACCGAGCTGGAGTTGTTCTACAGCGCCCGATCGGCTGCCG
ACCGGGCACGCGGCATCGAAGACATGCGGCTGCTGTTCGGCTGGGTCCCGGTCGACGACCGCGCTTACGAGCGGGCCTGG
CAGGTCCAGGAGGCCCTCACCAAGCAAGGCAAGCACCGCAGCGCAGGTGCGGTCGATCTCGTTGTCGCAGCGACTGCCGA
GCTGCAGGGGCTCACCCTCCTGCACCGTGACCACGACTTCGAATGCATCGCCGCAGTAACCGGCCAACCCCTCCAGTGGT
ACGGCCCGGAGGGCGGTAAGTAG

Antitoxin

Protein

• Length: 72 a.a.
• Molecular weight: 8051.13 Da
• Isoelectric Point: 8.6590

>AT105190 WP_079428878.1 NZ_CP029190:3578775-3578990 [Streptomyces venezuelae]
MSRTVIDLDDELVADVAKALGTSTKKETVNTALREVLENRRRALALTRLRAAADEGAFDLTLFEDKRNYRR

Nucleotide

• Length: 216 bp

>AT105190 NZ_CP029190:3578775-3578990 [Streptomyces venezuelae]
ATGAGTCGGACAGTGATTGATCTCGATGACGAGCTGGTGGCAGACGTAGCCAAAGCCTTGGGTACCAGCACGAAGAAGGA
GACGGTCAACACAGCCCTGCGCGAGGTGCTGGAGAACAGGCGGCGGGCGCTGGCCTTGACCCGCCTGCGCGCCGCGGCCG
ACGAAGGTGCGTTCGATCTGACACTCTTCGAGGACAAGCGGAACTACCGACGGTGA