Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YoeB-RelB
Location 2708047..2708573 Replicon chromosome
Accession NZ_CP029190
Organism Streptomyces venezuelae strain ATCC 21782

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag DEJ50_RS11695 Protein ID WP_150207653.1
Coordinates 2708319..2708573 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag DEJ50_RS11690 Protein ID WP_150207650.1
Coordinates 2708047..2708322 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DEJ50_RS11660 2703605..2704027 + 423 WP_190344432.1 NUDIX domain-containing protein -
DEJ50_RS11665 2704034..2704747 - 714 WP_150207640.1 NAD(P)-binding domain-containing protein -
DEJ50_RS11670 2704853..2705158 - 306 WP_150207642.1 hypothetical protein -
DEJ50_RS11675 2705267..2706658 - 1392 WP_150207644.1 HAMP domain-containing histidine kinase -
DEJ50_RS11680 2706655..2707344 - 690 WP_150207646.1 response regulator transcription factor -
DEJ50_RS11685 2707423..2707974 + 552 WP_150207649.1 hypothetical protein -
DEJ50_RS11690 2708047..2708322 + 276 WP_150207650.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
DEJ50_RS11695 2708319..2708573 + 255 WP_150207653.1 Txe/YoeB family addiction module toxin Toxin
DEJ50_RS11700 2708595..2709485 - 891 WP_190344434.1 fused MFS/spermidine synthase -
DEJ50_RS11705 2709543..2709938 - 396 WP_150207657.1 hypothetical protein -
DEJ50_RS11710 2710186..2711526 + 1341 WP_150207659.1 tetratricopeptide repeat protein -
DEJ50_RS11715 2711580..2712173 - 594 WP_150207660.1 histidine phosphatase family protein -
DEJ50_RS11720 2712273..2713106 + 834 WP_150207662.1 phosphatase PAP2 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-72)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10033.46 Da        Isoelectric Point: 9.8626

>T105188 WP_150207653.1 NZ_CP029190:2708319-2708573 [Streptomyces venezuelae]
MKVVFSDAAWNQYTFWATADPEVLKRINRLIQEIKRTPFEGIGKPEPLKEGLSGWWSRRITDEHRLVYRVRDQAVEIAQA
RYHY

Download         Length: 255 bp

>T105188 NZ_CP029190:2708319-2708573 [Streptomyces venezuelae]
ATGAAGGTGGTCTTCTCCGACGCCGCGTGGAACCAGTACACGTTCTGGGCCACGGCGGACCCCGAGGTCCTCAAGAGGAT
CAACCGGCTGATCCAGGAGATCAAGCGAACGCCGTTCGAGGGGATCGGCAAGCCCGAGCCGCTCAAGGAAGGCCTGTCGG
GATGGTGGTCCCGCAGGATCACGGACGAGCACCGGCTCGTCTACCGCGTGCGGGACCAGGCCGTGGAAATCGCCCAGGCC
CGCTACCACTACTGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10259.39 Da        Isoelectric Point: 4.3521

>AT105188 WP_150207650.1 NZ_CP029190:2708047-2708322 [Streptomyces venezuelae]
VPISANEARQRFYPLIKRVNEDHEPIEVTSREHGDVVIMSAEDFRSWQETVYLLRSPRNAQILMESIAELDAGHGQAREL
IGIEDDEGAAA

Download         Length: 276 bp

>AT105188 NZ_CP029190:2708047-2708322 [Streptomyces venezuelae]
GTGCCCATTTCCGCGAACGAGGCCCGGCAGCGCTTCTACCCGCTGATCAAACGGGTCAACGAAGACCACGAGCCCATCGA
GGTCACCTCCCGCGAGCACGGCGACGTCGTCATCATGTCCGCCGAGGACTTCCGTTCCTGGCAGGAGACCGTCTATCTGC
TGCGCTCGCCGCGCAACGCCCAGATCCTGATGGAGTCCATCGCGGAGCTGGACGCCGGCCACGGGCAGGCCAGGGAACTG
ATCGGCATCGAGGACGACGAGGGCGCCGCCGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References