Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YoeB-YefM
Location 2863675..2864204 Replicon chromosome
Accession NZ_CP029189
Organism Streptomyces venezuelae strain ATCC 21018

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag DEJ51_RS12365 Protein ID WP_150257641.1
Coordinates 2863947..2864204 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag DEJ51_RS12360 Protein ID WP_150257640.1
Coordinates 2863675..2863950 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DEJ51_RS12345 2859878..2861248 - 1371 WP_150257638.1 NarK/NasA family nitrate transporter -
DEJ51_RS12350 2861345..2862310 - 966 WP_150257639.1 LysR family transcriptional regulator -
DEJ51_RS12355 2862405..2863640 + 1236 WP_190620908.1 MFS transporter -
DEJ51_RS12360 2863675..2863950 + 276 WP_150257640.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
DEJ51_RS12365 2863947..2864204 + 258 WP_150257641.1 Txe/YoeB family addiction module toxin Toxin
DEJ51_RS12375 2864731..2865216 - 486 WP_053631578.1 SsrA-binding protein SmpB -
DEJ51_RS12380 2865235..2866425 - 1191 WP_150257642.1 PDZ domain-containing protein -
DEJ51_RS12385 2866493..2867464 - 972 WP_150257643.1 permease-like cell division protein FtsX -
DEJ51_RS12390 2867482..2868171 - 690 WP_030011324.1 cell division ATP-binding protein FtsE -
DEJ51_RS12395 2868406..2868597 + 192 WP_150257644.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-71)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10191.62 Da        Isoelectric Point: 9.8313

>T105186 WP_150257641.1 NZ_CP029189:2863947-2864204 [Streptomyces venezuelae]
VRSVHFDPAAWEDFLFWLSSDRKMARRITRLIGEIQRDPFTGIGKPEPLKGELTGYWSRRIDDEHRLVYRADDKEAKILK
ARYHY

Download         Length: 258 bp

>T105186 NZ_CP029189:2863947-2864204 [Streptomyces venezuelae]
GTGAGGAGCGTCCACTTCGACCCCGCGGCCTGGGAGGACTTCCTGTTCTGGCTCTCCTCGGACCGGAAGATGGCTCGCCG
GATCACCCGCCTGATCGGCGAGATCCAGCGGGACCCGTTCACCGGCATCGGCAAGCCCGAACCGTTGAAGGGCGAGTTGA
CGGGCTACTGGTCCCGCCGCATCGACGACGAGCACCGCCTCGTGTACCGGGCCGACGACAAGGAAGCGAAGATCCTCAAG
GCGCGCTACCACTACTGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 9995.12 Da        Isoelectric Point: 4.3766

>AT105186 WP_150257640.1 NZ_CP029189:2863675-2863950 [Streptomyces venezuelae]
MSISASEARATLFPLIERVNTDHAPVRITSKSGDAVLMSADDYDSWQETVYLLRSPANAQRLMEAVARDREGASSVVRTL
DELRELAGGEE

Download         Length: 276 bp

>AT105186 NZ_CP029189:2863675-2863950 [Streptomyces venezuelae]
ATGTCCATAAGCGCCAGCGAAGCCAGGGCGACCCTGTTCCCGCTGATCGAGCGCGTGAACACCGACCACGCCCCGGTGCG
CATCACCTCCAAGAGCGGTGACGCGGTCCTCATGTCCGCCGACGACTACGACTCCTGGCAGGAGACCGTCTACCTCCTGC
GCTCCCCCGCCAACGCCCAGCGGTTGATGGAGGCCGTCGCGCGTGACCGCGAGGGCGCCTCCTCGGTCGTCAGGACGCTG
GACGAGTTGAGGGAGTTGGCCGGGGGCGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References