Detailed information of TA system TA105185

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 1232810..1233335
• Replicon: chromosome
• Accession: NZ_CP029188
• Organism: Streptomyces tirandamycinicus strain HNM0039

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: DDW44_RS05390
• Protein ID: WP_108905694.1
• Coordinates: 1233072..1233335 (+)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: DDW44_RS05385
• Protein ID: WP_108905693.1
• Coordinates: 1232810..1233079 (+)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DDW44_RS05365	1229345..1229890	+	546	WP_017947892.1	YbjN domain-containing protein	-
DDW44_RS05370	1229967..1231094	-	1128	WP_018891998.1	hypothetical protein	-
DDW44_RS05375	1231426..1231980	+	555	WP_108905692.1	Uma2 family endonuclease	-
DDW44_RS05385	1232810..1233079	+	270	WP_108905693.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
DDW44_RS05390	1233072..1233335	+	264	WP_108905694.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DDW44_RS05400	1233664..1234860	-	1197	WP_108905695.1	pyridoxal phosphate-dependent aminotransferase	-
DDW44_RS05405	1234983..1235204	+	222	WP_108905696.1	hypothetical protein	-
DDW44_RS05410	1235692..1236210	+	519	WP_018891991.1	DUF2617 family protein	-
DDW44_RS05415	1236291..1237823	+	1533	WP_208647938.1	polyamine aminopropyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (7-58)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 9999.43 Da
• Isoelectric Point: 8.5041

>T105185 WP_108905694.1 NZ_CP029188:1233072-1233335 [Streptomyces tirandamycinicus]
VSEYRTVFRPEAQAELRKIPRGVALRILAKLTELESDPMGFDTTALVSQPDRRRLRVGDYRVLYTIDNGELVVWVVHVGH
RSTVYDT

Nucleotide

• Length: 264 bp

>T105185 NZ_CP029188:1233072-1233335 [Streptomyces tirandamycinicus]
GTGAGTGAGTACCGCACCGTCTTCCGACCCGAGGCTCAGGCCGAACTCCGCAAGATCCCGCGAGGCGTGGCCCTCCGTAT
TCTGGCCAAGCTGACTGAGCTGGAGAGCGACCCGATGGGGTTCGACACCACGGCGCTCGTCTCCCAGCCCGACCGGCGCC
GCCTACGGGTGGGCGACTATCGCGTGCTCTACACGATCGACAACGGCGAGCTGGTGGTATGGGTCGTCCACGTCGGGCAT
CGCTCCACCGTCTACGACACCTGA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10339.81 Da
• Isoelectric Point: 4.7473

>AT105185 WP_108905693.1 NZ_CP029188:1232810-1233079 [Streptomyces tirandamycinicus]
MTQPMPIESIRDVRAHLAEVVERADRDDVPTVITRRGKQVAAVVSIEVLRKYQEWEEREINRIIDERMTSPTPGIPIEDI
MRETLARSE

Nucleotide

• Length: 270 bp

>AT105185 NZ_CP029188:1232810-1233079 [Streptomyces tirandamycinicus]
ATGACGCAACCCATGCCCATAGAGTCCATTCGTGATGTCCGGGCACACCTGGCCGAGGTCGTGGAGCGGGCCGACCGGGA
CGACGTGCCTACCGTCATCACCCGGCGCGGCAAGCAGGTCGCCGCCGTGGTGTCCATCGAGGTGCTGCGCAAGTACCAGG
AGTGGGAAGAGCGCGAGATCAACCGGATCATCGACGAGCGCATGACCAGCCCGACACCCGGCATCCCGATCGAGGACATC
ATGAGGGAGACGCTGGCGCGCAGTGAGTGA