Detailed information of TA system TA105184

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 3228515..3229055
• Replicon: chromosome
• Accession: NZ_CP029187
• Organism: Flavobacterium pallidum strain HYN0049

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: HYN49_RS13595
• Protein ID: WP_108904626.1
• Coordinates: 3228759..3229055 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: HYN49_RS13590
• Protein ID: WP_108904586.1
• Coordinates: 3228515..3228766 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HYN49_RS13560	3223785..3224336	+	552	WP_108904620.1	hypothetical protein	-
HYN49_RS13565	3224622..3224867	+	246	WP_108904621.1	hypothetical protein	-
HYN49_RS13570	3225032..3225520	+	489	WP_108904622.1	hypothetical protein	-
HYN49_RS13575	3225674..3226651	+	978	WP_108904623.1	DUF4365 domain-containing protein	-
HYN49_RS13580	3226815..3227303	+	489	WP_108904624.1	hypothetical protein	-
HYN49_RS13585	3227466..3228302	+	837	WP_108904625.1	hypothetical protein	-
HYN49_RS13590	3228515..3228766	+	252	WP_108904586.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
HYN49_RS13595	3228759..3229055	+	297	WP_108904626.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HYN49_RS13600	3229221..3229613	+	393	WP_108904627.1	hypothetical protein	-
HYN49_RS13605	3229779..3230372	+	594	WP_108904628.1	hypothetical protein	-
HYN49_RS13610	3230653..3230952	+	300	WP_181368968.1	DUF1311 domain-containing protein	-
HYN49_RS13615	3231119..3231463	+	345	WP_108904630.1	hypothetical protein	-
HYN49_RS13620	3231794..3232330	+	537	WP_108904631.1	KilA-N domain-containing protein	-
HYN49_RS13625	3232508..3232903	+	396	WP_108904632.1	RDD family protein	-
HYN49_RS15100	3233090..3233485	+	396	WP_146185114.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3209787..3232330	22543

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (9-92)

Antitoxin

• Antitoxin ParD (1-78)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11626.15 Da
• Isoelectric Point: 4.6389

>T105184 WP_108904626.1 NZ_CP029187:3228759-3229055 [Flavobacterium pallidum]
MAKFHLLYRAVDDLADIWDYTYDEWSERQADKYYQLLLDSCQEIAENPNIGKSYNQIVNNLFGYKSGEHLIFYLVVDAQE
IEVVRILHGSMDLKKKFQ

Nucleotide

• Length: 297 bp

>T105184 NZ_CP029187:3228759-3229055 [Flavobacterium pallidum]
ATGGCTAAATTTCATCTTTTATATAGAGCTGTTGATGATCTTGCGGATATTTGGGATTATACTTATGATGAATGGTCAGA
AAGACAAGCTGACAAATATTATCAATTGCTTCTCGATAGTTGCCAAGAAATAGCTGAGAATCCAAATATCGGAAAATCGT
ACAATCAAATTGTGAATAATCTGTTTGGCTATAAATCTGGCGAACATTTAATTTTCTATCTTGTAGTTGACGCACAGGAA
ATTGAAGTGGTTAGAATATTACACGGTAGTATGGATTTAAAGAAAAAGTTTCAATAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9272.45 Da
• Isoelectric Point: 10.0139

>AT105184 WP_108904586.1 NZ_CP029187:3228515-3228766 [Flavobacterium pallidum]
MGKNTSISLGNHFEHFVENTIAHGRFKNASEVVRAGLRLLEDEENRVVMLRNSIEEGIKSGRAENFDSQKFLAQLKASKK
ANG

Nucleotide

• Length: 252 bp

>AT105184 NZ_CP029187:3228515-3228766 [Flavobacterium pallidum]
ATGGGAAAGAATACTTCAATATCACTCGGAAATCACTTCGAACATTTCGTTGAAAACACAATTGCGCATGGCAGATTCAA
AAATGCAAGCGAAGTTGTTCGCGCCGGACTGCGCCTTTTGGAAGATGAAGAAAATCGAGTTGTAATGCTTCGAAATTCAA
TTGAGGAAGGAATTAAAAGTGGAAGAGCAGAAAACTTTGATTCTCAAAAATTTCTTGCTCAATTGAAAGCCAGCAAAAAA
GCGAATGGCTAA