Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 3195346..3195886 Replicon chromosome
Accession NZ_CP029187
Organism Flavobacterium pallidum strain HYN0049

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag HYN49_RS13385 Protein ID WP_108904587.1
Coordinates 3195590..3195886 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag HYN49_RS13380 Protein ID WP_108904586.1
Coordinates 3195346..3195597 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HYN49_RS13350 3191306..3191551 + 246 WP_108905084.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
HYN49_RS13355 3191542..3191865 + 324 WP_108904581.1 type II toxin-antitoxin system PemK/MazF family toxin -
HYN49_RS13360 3192045..3193163 + 1119 WP_108904582.1 DUF262 domain-containing protein -
HYN49_RS13365 3193153..3193803 + 651 WP_108904583.1 hypothetical protein -
HYN49_RS13370 3193965..3194426 + 462 WP_108904584.1 hypothetical protein -
HYN49_RS13375 3194587..3195129 + 543 WP_108904585.1 hypothetical protein -
HYN49_RS13380 3195346..3195597 + 252 WP_108904586.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
HYN49_RS13385 3195590..3195886 + 297 WP_108904587.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HYN49_RS13390 3196055..3196633 + 579 WP_108904588.1 hypothetical protein -
HYN49_RS13395 3196797..3197645 + 849 WP_108904589.1 hypothetical protein -
HYN49_RS13400 3197804..3198187 + 384 WP_108904590.1 hypothetical protein -
HYN49_RS15190 3198281..3198430 - 150 WP_181368966.1 hypothetical protein -
HYN49_RS13405 3198512..3198715 - 204 WP_108904591.1 hypothetical protein -
HYN49_RS13410 3198948..3200057 - 1110 WP_108905085.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(9-92)

Antitoxin

Antitoxin ParD

(1-78)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11654.21 Da        Isoelectric Point: 4.6389

>T105183 WP_108904587.1 NZ_CP029187:3195590-3195886 [Flavobacterium pallidum]
MAKFHLLYRAVDDLADIWDYTYDEWSERQADKYYQLLLDSCQEIAENPNIGKSYNQIVNNLFGYKSGEHLIFYLVVDVQE
IEVVRILHGSMDLKKKFQ

Download         Length: 297 bp

>T105183 NZ_CP029187:3195590-3195886 [Flavobacterium pallidum]
ATGGCTAAATTTCATCTTTTATATAGAGCTGTTGATGATCTTGCGGATATTTGGGATTATACTTATGATGAATGGTCAGA
AAGACAAGCTGACAAATATTATCAATTGCTTCTCGATAGTTGCCAAGAAATAGCTGAGAATCCAAATATCGGAAAATCGT
ACAATCAAATTGTGAATAATCTGTTTGGCTATAAATCTGGCGAACATTTAATTTTCTATCTTGTAGTTGACGTACAGGAA
ATTGAAGTGGTTAGAATATTACACGGTAGTATGGATTTAAAGAAAAAGTTTCAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9272.45 Da        Isoelectric Point: 10.0139

>AT105183 WP_108904586.1 NZ_CP029187:3195346-3195597 [Flavobacterium pallidum]
MGKNTSISLGNHFEHFVENTIAHGRFKNASEVVRAGLRLLEDEENRVVMLRNSIEEGIKSGRAENFDSQKFLAQLKASKK
ANG

Download         Length: 252 bp

>AT105183 NZ_CP029187:3195346-3195597 [Flavobacterium pallidum]
ATGGGAAAGAATACTTCAATATCACTCGGAAATCACTTCGAACATTTCGTTGAAAACACAATTGCGCATGGCAGATTCAA
AAATGCAAGCGAAGTTGTTCGCGCCGGACTGCGCCTTTTGGAAGATGAAGAAAATCGAGTTGTAATGCTTCGAAATTCAA
TTGAGGAAGGAATTAAAAGTGGAAGAGCAGAAAACTTTGATTCTCAAAAATTTCTTGCTCAATTGAAAGCCAGCAAAAAA
GCGAATGGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References