Detailed information of TA system TA105180

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 2316822..2317375
• Replicon: chromosome
• Accession: NZ_CP029185
• Organism: Limnobaculum parvum strain HYN0051

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: -
• Locus tag: HYN51_RS09740
• Protein ID: WP_108899854.1
• Coordinates: 2316822..2317130 (-)
• Length: 103 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: -
• Locus tag: HYN51_RS09745
• Protein ID: WP_108899855.1
• Coordinates: 2317133..2317375 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HYN51_RS09715	2312628..2313536	-	909	WP_108902017.1	sulfate adenylyltransferase subunit CysD	-
HYN51_RS09720	2313569..2315005	-	1437	WP_108899850.1	siroheme synthase CysG	-
HYN51_RS09725	2315198..2316115	+	918	WP_108899851.1	dienelactone hydrolase family protein	-
HYN51_RS09730	2316096..2316212	-	117	WP_108899852.1	CcdB family protein	-
HYN51_RS09735	2316407..2316670	+	264	WP_108899853.1	hypothetical protein	-
HYN51_RS09740	2316822..2317130	-	309	WP_108899854.1	CcdB family protein	Toxin
HYN51_RS09745	2317133..2317375	-	243	WP_108899855.1	type II toxin-antitoxin system CcdA family antitoxin	Antitoxin
HYN51_RS09750	2317983..2318717	-	735	WP_108899856.1	phosphoadenylyl-sulfate reductase	-
HYN51_RS09755	2318727..2320424	-	1698	WP_108899857.1	assimilatory sulfite reductase (NADPH) hemoprotein subunit	-
HYN51_RS09760	2320424..2322229	-	1806	WP_108899858.1	NADPH-dependent assimilatory sulfite reductase flavoprotein subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin CcdB (2-101)

Antitoxin

• Post-segregation antitoxin CcdA (10-80)

Sequences

Toxin

Protein

• Length: 103 a.a.
• Molecular weight: 11893.76 Da
• Isoelectric Point: 7.2401

>T105180 WP_108899854.1 NZ_CP029185:c2317130-2316822 [Limnobaculum parvum]
VQYTVYRNTGNNKDYPYLLNVQSDLIDALTTRWVIPLFPRRRFKGKVPQHLCPILSIGEVEYLLMTHEMASVRKSMLGDE
VCQAQHYRDEIKAAIDFMIDGF

Nucleotide

• Length: 309 bp

>T105180 NZ_CP029185:c2317130-2316822 [Limnobaculum parvum]
GTGCAATATACTGTCTATCGTAATACGGGTAATAACAAGGATTACCCGTACTTATTGAATGTACAAAGTGACCTGATTGA
TGCGTTGACAACGCGATGGGTGATTCCACTCTTCCCCCGTCGCCGATTTAAAGGAAAGGTCCCTCAACACTTATGCCCGA
TACTGAGTATTGGGGAAGTTGAGTACTTATTGATGACGCATGAGATGGCCAGCGTTCGCAAAAGTATGCTGGGTGACGAA
GTGTGCCAGGCCCAGCATTATCGCGATGAGATTAAAGCCGCGATTGATTTTATGATTGATGGTTTTTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8934.17 Da
• Isoelectric Point: 7.2013

>AT105180 WP_108899855.1 NZ_CP029185:c2317375-2317133 [Limnobaculum parvum]
MTKTHAKITKKTVSVTLDPVLYQKARDMGINLSAVLTQAIEAQLQAASAAQWKHENRQAMEELNRISDESGLLSDEYKAF

Nucleotide

• Length: 243 bp

>AT105180 NZ_CP029185:c2317375-2317133 [Limnobaculum parvum]
ATGACAAAAACCCATGCAAAAATAACCAAAAAGACGGTCAGTGTGACGTTGGATCCAGTTTTGTATCAAAAGGCTCGCGA
TATGGGTATCAATTTATCAGCAGTATTGACTCAAGCCATTGAGGCACAGTTACAGGCAGCATCTGCTGCTCAATGGAAGC
ATGAAAACCGGCAGGCGATGGAAGAGCTAAACCGGATTAGTGATGAGAGCGGCTTACTTTCCGATGAATATAAGGCATTT
TGA